Abstract: The medical laser user interface of the present invention generally comprises a medical laser unit and a control system. The medical laser unit includes an optical probe for delivering laser light to a patient's tissue. The control system controls operation of the medical laser unit. Specifically, the control system provides a foot pedal system that enables the user to switch between the delivery of a first wavelength of laser light and a second wavelength of laser light through depression of a foot pedal. In a first embodiment, a single foot pedal can be used to toggle the wavelengths, where as in a second embodiment two foot pedals can be use, one for the first wavelength and one for the second wavelength. The two wavelengths provided include a wavelength for vaporization of tissue and a wavelength for coagulation.

Abstract: The medical laser user interface of the present invention generally comprises a medical laser unit and a control system. The medical laser unit includes an optical probe for delivering laser light to a patient's tissue. The control system controls operation of the medical laser unit. Specifically, the control system provides a foot pedal system that enables the user to switch between the delivery of a first wavelength of laser light and a second wavelength of laser light through depression of a foot pedal. In a first embodiment, a single foot pedal can be used to toggle the wavelengths, where as in a second embodiment two foot pedals can be use, one for the first wavelength and one for the second wavelength. The two wavelengths provided include a wavelength for vaporization of tissue and a wavelength for coagulation.

Abstract: The medical laser user interface of the present invention generally comprises a medical laser unit and a control system. The medical laser unit includes an optical probe for delivering laser light to a patient's tissue. The control system controls operation of the medical laser unit. Specifically, the control system provides a foot pedal system that enables the user to switch between the delivery of a first wavelength of laser light and a second wavelength of laser light through depression of a foot pedal. In a first embodiment, a single foot pedal can be used to toggle the wavelengths, where as in a second embodiment two foot pedals can be use, i.e., one for the first wavelength and one for the second wavelength. The two wavelengths provided include a wavelength for vaporization of tissue and a wavelength for coagulation.

Abstract: The invention provides methods of diagnosing Graves' disease (GD), Rheumatoid Arthritis (RA) and other autoimmune diseases in an individual by detecting a disproportionately large fraction of peripheral blood T cells express IGF-1R (CD3+ IGF-R+) compared to normal control samples. In a further embodiment, the invention provides methods of diagnosing, prognosing, staging, and/or monitoring GD, RA and other autoimmune diseases. Or a predisposition thereto in an individual by detecting a disproportionately large fraction of CD3+ IGF-1R+ T cells that express CD45RO+ compared to normal control samples. In a further embodiment, the invention provides a method of diagnosing, prognosing, staging, and/or monitoring GD, RA and other autoimmune diseases or a predisposition thereto in an individual by detecting an increased CD45RO+/RA+ ratio in peripheral blood T cells compared to normal control samples.

Abstract: The invention provides a method of reducing the severity of an autoimmune condition associated with T-lymphocyte infiltration. The invention also provides a method of diagnosing or predicting the susceptibility to an autoimmune disease associated with fibroblast mediated T-lymphocyte infiltration. Methods of identifying a substance capable of modulating T-lymphocyte recruitment associated with an autoimmune condition also are provided.

Abstract: The present invention describes diagnosis and treatment of antibody-mediated inflammatory auto-immune diseases. The biochemical mechanisms underlying such disorders are described as characteristic molecular markers and antibody-mediated ligand-receptor interactions. Specifically, the activation of T-cells by disease specific IgG binding to the IGF-1 receptor is shown to underlie thyroid associated ophthalmopathy associated with Graves' disease and rheumatoid arthritis. Diagnostics for detection of disease are provided, as are therapeutics based on the determination of the mechanisms underlying a particular pathology.

Abstract: The medical laser user interface of the present invention generally comprises a medical laser unit and a control system. The medical laser unit includes an optical probe for delivering laser light to a patient's tissue. The control system controls operation of the medical laser unit. Specifically, the control system provides a foot pedal system that enables the user to switch between the delivery of a first wavelength of laser light and a second wavelength of laser light through depression of a foot pedal. In a first embodiment, a single foot pedal can be used to toggle the wavelengths, where as in a second embodiment two foot pedals can be use, i.e., one for the first wavelength and one for the second wavelength. The two wavelengths provided include a wavelength for vaporization of tissue and a wavelength for coagulation.

Abstract: The present invention describes a method to detect connective tissue pathologies associated with Graves' disease ophthalmopathy and other antibody mediated inflammatory autoimmune diseases. The detection method comprises obtaining a sample from a patient suffering from an antibody-mediated inflammatory autoimmune disorder and measuring Interleukin 16 (IL-16) or RANTES produced by thyroid associated ophthalmopathy fibroblasts to indicate the presence or severity.

Abstract: The present invention describes diagnosis and treatment of antibody-mediated inflammatory auto-immune diseases. The biochemical mechanisms underlying such disorders are described as characteristic molecular markers and antibody-mediated ligand-receptor interactions. Specifically, the activation of T-cells by disease specific IgG binding to the IGF-1 receptor is shown to underlie thyroid associated ophthalmopathy associated with Graves' disease and rheumatoid arthritis. Diagnostics for detection of disease are provided, as are therapeutics based on the determination of the mechanisms underlying a particular pathology.

Abstract: The invention provides a method of reducing the severity of an autoimmune condition associated with T-lymphocyte infiltration. The invention also provides a method of diagnosing or predicting the susceptibility to an autoimmune disease associated with fibroblast mediated T-lymphocyte infiltration. Methods of identifying a substance capable of modulating T-lymphocyte recruitment associated with an autoimmune condition also are provided.

Abstract: The present invention describes a novel therapy to modulate the connective tissue pathologies associated with Graves' disease ophthalmopathy and other antibody-mediated inflammatory auto-immune diseases. The therapy comprises administering to a patient suffering from an antibody-mediated inflammatory auto-immune disorder an Interleukin 16 (IL-16) activity inhibitor and/or a RANTES activity inhibitor in order to decrease the proliferation of CD4-bearing leukocytes at the site of the disease. Especially preferred IL-16 activity inhibitor for use in the therapeutic methods of the present invention are rapamycin and PD098059, and an especially preferred RANTES inhibitor for use in the present invention is compound SB203580.

Abstract: The apparatus is an attenuator for use in an optical fiber link. The attenuator is a full circular loop of continuous optical fiber with connection means at the ends of the loop to interconnect with the other optical fiber components in the system. The attenuation of optical transmission through the loop is continuously variable by twisting the loop out of its original planar configuration. A lockable rotating shaft clamped to the side of the loop remote from the connection means is turned to rotate the loop.

Abstract: Apparatus for determining and broadcasting the approximate location of a person or other object that has fallen overboard from a boat or other structure into a body of water. The apparatus includes a floatable object that is thrown into the water near the overboard person/object to broadcast the location of the object and the nearby overboard person. The floatable object includes: an activatable Satellite Positioning System (SPS) receiver/processor and antenna to receive SPS signals from two or more SPS satellites; an activatable location transmitter and transmitter interface to receive the SPS-determined location information from the SPS receiver/processor; a power supply to supply power to the SPS receiver/processor and the location transmitter; and activation means to activate the SPS receiver/processor and location transmitter.

Abstract: Apparatus that is carried on a land vehicle, a marine vehicle or vessel, or an airborne vehicle or vessel for notifying others that a vehicle accident or other abnormal situation has occurred and for notifying others of the location of the vehicle at the time of the accident. The vehicle carries an distance measuring system (DMS) signal antenna and receiver/processor that receives DMS-type signals from one or more DMS signal broadcasters and determines the present position of the vehicle, plus an activatable transmitter. The vehicle also carries an abnormality sensing means that senses the occurrence of an accident or other abnormal situation involving the vehicle or a vehicle occupant. When an abnormal situation is sensed, the abnormality sensing means automatically activates the transmitter, which then communicates the fact that an abnormal situation has occurred and the location of the vehicle at the time the event occurred.

Abstract: An apparatus for measuring the contact force of a terminal mounted in a multi-terminal circuit board connector, the measured force being applied normal to the surface of a circuit board received in the connector, has a transducer employing four strain gauges connected in a bridge arrangement with pairs of the gauges being positioned at opposite ends of a fully supported beam. The strain at the end points of the beam are averaged by the strain gauges so that no matter where the forces are applied normal to the beam by the terminal being measured, the deflection is always negligible and the area of the beam upon which the contact force is applied is not critical.

Abstract: Apparatus that is carried on a land vehicle, a marine vehicle or vessel, or an airborne vehicle or vessel for notifying others that a vehicle accident or other abnormal situation has occurred and for notifying others of the location of the vehicle at the time of the accident. The vehicle carries an distance measuring system (DMS) signal antenna and receiver/processor that receives DMS-type signals from one or more DMS signal broadcasters and determines the present position of the vehicle, plus an activatable transmitter. The vehicle also carries an abnormality sensing means that senses the occurrence of an accident or other abnormal situation involving the vehicle or a vehicle occupant. When an abnormal situation is sensed, the abnormality sensing means automatically activates the transmitter, which then communicates the fact that an abnormal situation has occurred and the location of the vehicle at the time the event occurred.