Patents by Inventor Terry L. Riss

Terry L. Riss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Kits for luminogenic and nonluminogenic multiplex assays
    Patent number: 8715950
    Abstract: Methods and kits to detect the presence or amount of at least one molecule for an enzyme-mediated reaction in a multiplex luminogenic/nonluminogenic assay are provided.
    Type: Grant
    Filed: June 25, 2008
    Date of Patent: May 6, 2014
    Assignee: Promega Corporation
    Inventors: Terry L. Riss, Andrew Niles, Richard A. Moravec
  • Nonluminogenic assay for living cells
    Patent number: 8476036
    Abstract: A method to detect the presence or amount of at least one molecule for an enzyme-mediated reaction in a multiplex luminogenic/nonluminogenic assay is provided.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: July 2, 2013
    Assignee: Promega Corporation
    Inventors: Andrew Niles, Terry L. Riss
  • LUMINOGENIC AND NONLUMINOGENIC MULTIPLEX ASSAY
    Publication number: 20090275051
    Abstract: A method to detect the presence or amount of at least one molecule for an enzyme-mediated reaction in a multiplex luminogenic/nonluminogenic assay is provided.
    Type: Application
    Filed: June 29, 2009
    Publication date: November 5, 2009
    Applicant: PROMEGA CORPORATION
    Inventors: ANDREW NILES, TERRY L. RISS
  • Luminogenic and nonluminogenic multiplex assay
    Patent number: 7553632
    Abstract: A method to detect the presence or amount of at least one molecule for an enzyme-mediated reaction in a multiplex luminogenic/nonluminogenic assay is provided.
    Type: Grant
    Filed: July 20, 2006
    Date of Patent: June 30, 2009
    Assignee: Promega Corporation
    Inventors: Andrew Niles, Terry L. Riss
  • Luminogenic and nonluminogenic multiplex assay
    Publication number: 20090017482
    Abstract: A method to detect the presence or amount of at least one molecule for an enzyme-mediated reaction in a multiplex luminogenic/nonluminogenic assay is provided.
    Type: Application
    Filed: August 31, 2007
    Publication date: January 15, 2009
    Inventors: Terry L. Riss, Andrew Niles, Richard A. Moravec
  • LUMINOGENIC AND NONLUMINOGENIC MULTIPLEX ASSAY
    Publication number: 20080268482
    Abstract: A method to detect the presence or amount of at least one molecule for an enzyme-mediated reaction in a multiplex luminogenic/nonluminogenic assay is provided.
    Type: Application
    Filed: June 25, 2008
    Publication date: October 30, 2008
    Inventors: Terry L. Riss, Andrew Niles, Richard A. Moravec
  • Luminogenic and nonluminogenic multiplex assay
    Patent number: 7416854
    Abstract: A method to detect the presence or amount of at least one molecule for an enzyme-mediated reaction in a multiplex luminogenic/nonluminogenic assay is provided.
    Type: Grant
    Filed: January 22, 2004
    Date of Patent: August 26, 2008
    Assignee: Promega Corporation
    Inventors: Terry L. Riss, Andrew Niles, Richard A. Moravec
  • Kit for measuring cytotoxicity of a test agent
    Patent number: 7282348
    Abstract: Disclosed are a method and a corresponding kit for determining the cytotoxicity of a test agent. The method includes the steps of adding a pre-determined amount of the test agent to a vessel containing living cells in culture medium. The cells are then incubated for a pre-determined amount of time. To the cells and culture medium is then added a reagent mixture that is non-toxic to the living cells. In the preferred embodiment, the reagent mixture contains a solvent, a dye, an electron transfer agent, a substrate for a cytoplasmic enzyme having a half-life greater than two hours and NAD+. The contents of the vessel are then measured for production of the reduced state of the dye, the production of the reduced state of the dye being caused by a cytoplasmic enzyme specific for the substrate in the reagent mixture. In the preferred embodiment, the production of the reduced state of the dye is caused by lactate dehydrogenase released from dead and dying cells within the vessel.
    Type: Grant
    Filed: March 24, 2005
    Date of Patent: October 16, 2007
    Assignee: Promega Corporation
    Inventors: Terry L. Riss, Richard A. Moravec
  • Cytotoxicity assay
    Patent number: 6982152
    Abstract: Disclosed are a method and a corresponding kit for determining the cytotoxicity of a test agent. The method includes the steps of adding a pre-determined amount of the test agent to a vessel containing living cells in culture medium. The cells are then incubated for a pre-determined amount of time. To the cells and culture medium is then added a reagent mixture that is non-toxic to the living cells. In the preferred embodiment, the reagent mixture contains a solvent, a dye, an electron transfer agent, a substrate for a cytoplasmic enzyme having a half-life greater than two hours and NAD+. The contents of the vessel are then measured for production of the reduced state of the dye, the production of the reduced state of the dye being caused by a cytoplasmic enzyme specific for the substrate in the reagent mixture. In the preferred embodiment, the production of the reduced state of the dye is caused by lactate dehydrogenase released from dead and dying cells within the vessel.
    Type: Grant
    Filed: April 17, 2002
    Date of Patent: January 3, 2006
    Assignee: Promega Corporation
    Inventors: Terry L. Riss, Richard A. Moravec
  • Cytotoxicity assay
    Publication number: 20030203420
    Abstract: Disclosed are a method and a corresponding kit for determining the cytotoxicity of a test agent. The method includes the steps of adding a pre-determined amount of the test agent to a vessel containing living cells in culture medium. The cells are then incubated for a pre-determined amount of time. To the cells and culture medium is then added a reagent mixture that is non-toxic to the living cells. In the preferred embodiment, the reagent mixture contains a solvent, a dye, an electron transfer agent, a substrate for a cytoplasmic enzyme having a half-life greater than two hours and NAD+. The contents of the vessel are then measured for production of the reduced state of the dye, the production of the reduced state of the dye being caused by a cytoplasmic enzyme specific for the substrate in the reagent mixture. In the preferred embodiment, the production of the reduced state of the dye is caused by lactate dehydrogenase released from dead and dying cells within the vessel.
    Type: Application
    Filed: April 17, 2002
    Publication date: October 30, 2003
    Inventors: Terry L. Riss, Richard A. Moravec