Patents by Inventor Terry Lyle

Terry Lyle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydroxy pyridopyrrolopyrazine dione compounds useful as hiv integrase inhibitors
    Publication number: 20070093496
    Abstract: Hydroxy-substituted pyridopyrrolopyrazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula (I): (I) wherein a, b, A, B, R1, R2, R3, R4, R5, R6, R7 and R8 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
    Type: Application
    Filed: October 18, 2004
    Publication date: April 26, 2007
    Inventors: John Wai, Thorsten Fisher, Linghang Zhuang, Donnette Staas, Terry Lyle, Boyoung Kim, Mark Embrey, Catherine Wiscount, Lekhanh Tran, Melissa Egbertson, Kelly Savage
  • Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors
    Publication number: 20060024330
    Abstract: 8,9-Dihydroxydihydropyridopyrazine-1,6-diones and 8,9-dihydroxypyridopyrazine-1,6-diones are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the pyridopyrazinediones are of Formula (I): (I), wherein R1, R2, R3, R4 and R5 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are described.
    Type: Application
    Filed: September 10, 2003
    Publication date: February 2, 2006
    Inventors: John Wai, Boyoung Kim, Thorsten Fisher, Linghang Zhuang, Peter Williams, Terry Lyle, H. Langford, Kyle Robinson
  • Thrombin inhibitors
    Patent number: 6376499
    Abstract: Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, wherein b is N Y1 or O; c is CY2 or N; d is CY2; e is CY1 or N; f is CY1 or N; g is CY1 or N; Y1 is hydrogen, C1-4 alkyl, or halogen; Y2 is hydrogen, C1-4 alkyl, C3-7 cycloalkyl, halogen, NH2, OH or C1-4 alkoxy; A is  and W, X, Z, R3, R4 and R5 are defined in the specification.
    Type: Grant
    Filed: October 28, 1999
    Date of Patent: April 23, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Philip E. Sanderson, Terry Lyle, Bruce Dorsey, Matthew G. Stanton, Adel M. Naylor-Olsen