Abstract: Disclosed herein are compounds that can act as inhibitors of the Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2 (“KEAP1/NRF2”) protein-protein interaction, and methods of using the compounds to treat and prevent diseases and disorders, such as COPD, multiple sclerosis, and diabetes, and in the promotion of wound healing. The compounds described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: formula (I), wherein the substituents are as described.

Abstract: Disclosed herein are compounds that can act as inhibitors of the Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2 (“KEAP1/NRF2”) protein-protein interaction, and methods of using the compounds to treat and prevent diseases and disorders, such as COPD, multiple sclerosis, and diabetes, and in the promotion of wound healing. The compounds described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: formula (I), wherein the substituents are as described.

Abstract: An adaptive feedback control method is provided for a chemical mechanical polish process to minimize a dielectric layer clearing time difference between two annular regions on a substrate. An optical system with an optical window passes below the polishing pad and detects reflected light interference signals from at least two annular regions. A pre-clearing time difference is determined and is used to calculate an adjustment to one or both of a CMP head membrane pressure and a retaining ring pressure. The pressure adjustment is applied before the end of the polish cycle to avoid the need for a second polish cycle and to reduce a dishing difference and a resistance difference in a metal layer in the at least two annular regions. In some embodiments, a second pressure adjustment is performed before the end of the cycle and different CMP head membrane pressure adjustments are made in different pressure zones.

Abstract: An adaptive feedback control method is provided for a chemical mechanical polish process to minimize a dielectric layer clearing time difference between two annular regions on a substrate. An optical system with an optical window passes below the polishing pad and detects reflected light interference signals from at least two annular regions. A pre-clearing time difference is determined and is used to calculate an adjustment to one or both of a CMP head membrane pressure and a retaining ring pressure. The pressure adjustment is applied before the end of the polish cycle to avoid the need for a second polish cycle and to reduce a dishing difference and a resistance difference in a metal layer in the at least two annular regions. In some embodiments, a second pressure adjustment is performed before the end of the cycle and different CMP head membrane pressure adjustments are made in different pressure zones.

Abstract: A method for measuring fluid flow rates comprises the steps of: (a) creating a non-oscillating magnetic field of a predetermined strength across a flowing fluid; (b) performing the sub-steps of: (i) exposing the flowing fluid to an oscillating magnetic field pulse orthogonal to the non-oscillating magnetic field to generate an NMR signal, and (ii) detecting the NMR signal from the flowing fluid in the form of a free induction decay; and (c) determining the fluid flow rate from the initial magnitude of the free induction decay.

Abstract: A device for dispensing fertilizer into a fluid flowing in a pipe includes a fertilizer tank and a coupling communicating with the pipe. Optionally, the tank includes a pressure gauge, a sight glass, and a fill port with a fitting that engages a fitting on a cap or a funnel. In an optional embodiment, the tank and coupling communicate through an in-flow tube and an out-flow tube. An in-flow inlet on the tank receives a flow of fluid through the coupling from the pipe. Fluid flowing into the tank forces fertilizer from the tank through an out-flow outlet that communicates with the coupling.

Abstract: A method for filtering spurious resonances from an NMR dataset comprises the steps of: (a) creating a first, non-oscillating magnetic field of a predetermined field strength across a sample, (b) intermittently exposing the sample to a second, oscillating magnetic field orthogonal to the first to generate an NMR signal, (c) detecting the NMR signal from the sample, (d) adjusting the first magnetic field to a different predetermined field strength and repeating steps (a) to (c), and (d) comparing the detected signals to obtain an NMR dataset from the sample from which spurious resonances have been filtered.

Abstract: A method for measuring fluid flow rates comprises the steps of: (a) creating a non-oscillating magnetic field of a predetermined strength across a flowing fluid; (b) performing the sub-steps of: (i) exposing the flowing fluid to an oscillating magnetic field pulse orthogonal to the non-oscillating magnetic field to generate an NMR signal, and (ii) detecting the NMR signal from the flowing fluid in the form of a free induction decay; and (c) determining the fluid flow rate from the initial magnitude of the free induction decay.

Abstract: A method for filtering spurious resonances from an NMR dataset comprises the steps of: (a) creating a first, non-oscillating magnetic field of a predetermined field strength across a sample, (b) intermittently exposing the sample to a second, oscillating magnetic field orthogonal to the first to generate an NMR signal, (c) detecting the NMR signal from the sample, (d) adjusting the first magnetic field to a different predetermined field strength and repeating steps (a) to (c), and (d) comparing the detected signals to obtain an NMR dataset from the sample from which spurious resonances have been filtered.

Abstract: An improved insert for a chain link fence wherein a plurality of such inserts, each formed in a shape substantially the same as the square or diamond shaped matrix formed by the wires of the fence crossing over each, are connected to each other entrapping there between the wires from which the fence is formed.

Abstract: The present invention is a thorax phantom that enables simulation of tumor motion within a tissue equivalent material. The system consists of a tissue equivalent epoxy phantom representing a 15 cm axial section of the human thorax that includes simplified spine and lung anatomies. Within the phantom are thru rods of similar tissue density. The rods are attached to a computer-controlled actuator that facilitates both linear and rotational motion of the rods within the phantom. A plurality of tumor targets and radiation detectors can be placed within the rods at various locations thereby enabling the simulation of respiratory and cardiac induced tumor motions within the phantom and assessment of the effects of these motions on image acquisitions, treatment planning and radiation treatment delivery.