Abstract: Systems and methods for de-identifying patient data are disclosed herein. In some embodiments, a method for de-identifying patient data includes receiving a patient record including one or more identifiers. The method can include generating a first de-identified record from the patient record using a first de-identification process. The first de-identification process can be configured to produce a first re-identification risk score. The method can further include receiving a request from a data recipient to access the first de-identified record. The method can also include generating a second de-identified record from the first de-identified record by using a second de-identification process. The second de-identification process can be configured to produce a second re-identification risk score lower than the first re-identification risk score.