Patents by Inventor Teruhiko Ishikawa
Teruhiko Ishikawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11753385Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: GrantFiled: October 6, 2021Date of Patent: September 12, 2023Assignees: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko Ishikawa, Morita Iwami
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Publication number: 20220024883Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: ApplicationFiled: October 6, 2021Publication date: January 27, 2022Applicants: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko ISHIKAWA, Morita IWAMI
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Patent number: 11155526Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: GrantFiled: September 21, 2018Date of Patent: October 26, 2021Assignees: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko Ishikawa, Morita Iwami
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Patent number: 11066374Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: GrantFiled: September 21, 2018Date of Patent: July 20, 2021Assignees: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko Ishikawa, Morita Iwami
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Patent number: 10980813Abstract: Provided is an antifungal composition containing a cyclic N-sulfonylamine compound, a cyclic N-sulfonylimine compound or a cyclic N-sulfonyloxaziridine compound, each having an antifungal activity, as an active ingredient. An antifungal composition containing a compound represented by the formula (1): wherein ring A is an optionally further substituted 5- to 7-membered heterocycle, and the 5- to 7-membered heterocycle is optionally condensed with 1 or 2 rings selected from an optionally substituted benzene ring and an optionally substituted 5- to 7-membered heterocycle, X is —N?, —NR2— or —O—; Y1 is a hydrogen atom, and Y2 is a hydroxy group or Y1 and Y2 may be joined to form a bond or —O—; R1 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and R2 is a hydrogen atom or an optionally substituted hydrocarbon group, or a salt thereof as an active ingredient.Type: GrantFiled: February 27, 2018Date of Patent: April 20, 2021Assignee: SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko Ishikawa, Morita Iwami
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Patent number: 10703732Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: GrantFiled: September 21, 2018Date of Patent: July 7, 2020Assignees: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko Ishikawa, Morita Iwami
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Patent number: 10618876Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: GrantFiled: September 21, 2018Date of Patent: April 14, 2020Assignees: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko Ishikawa, Morita Iwami
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Publication number: 20190216820Abstract: Provided is an antifungal composition containing a cyclic N-sulfonylamine compound, a cyclic N-sulfonylimine compound or a cyclic N-sulfonyloxaziridine compound, each having an antifungal activity, as an active ingredient. An antifungal composition containing a compound represented by the formula (1): wherein ring A is an optionally further substituted 5- to 7-membered heterocycle, and the 5- to 7-membered heterocycle is optionally condensed with 1 or 2 rings selected from an optionally substituted benzene ring and an optionally substituted 5- to 7-membered heterocycle, X is —N?, —NR2— or —O—; Y1 is a hydrogen atom, and Y2 is a hydroxy group or Y1 and Y2 may be joined to form a bond or —O—; R1 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and R2 is a hydrogen atom or an optionally substituted hydrocarbon group, or a salt thereof as an active ingredient.Type: ApplicationFiled: February 27, 2018Publication date: July 18, 2019Applicant: SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko ISHIKAWA, Morita IWAMI
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Publication number: 20190152929Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: ApplicationFiled: September 21, 2018Publication date: May 23, 2019Applicants: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko ISHIKAWA, Morita IWAMI
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Publication number: 20190023669Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: ApplicationFiled: September 21, 2018Publication date: January 24, 2019Applicants: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko ISHIKAWA, Morita IWAMI
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Publication number: 20190023667Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: ApplicationFiled: September 21, 2018Publication date: January 24, 2019Applicants: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko ISHIKAWA, Morita IWAMI
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Publication number: 20190023668Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: ApplicationFiled: September 21, 2018Publication date: January 24, 2019Applicants: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko ISHIKAWA, Morita IWAMI
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Patent number: 10106509Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: GrantFiled: February 26, 2016Date of Patent: October 23, 2018Assignees: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko Ishikawa, Morita Iwami
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Patent number: 9988396Abstract: Provided are an oxaziridine compound showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, and a production method thereof. A compound represented by the formula 1: wherein X is a single bond, —C(H)(R6)— or —C(H)(R7)—C(H)(R8)—; and R1-R8 are each independently a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, or a salt thereof.Type: GrantFiled: January 26, 2017Date of Patent: June 5, 2018Assignee: SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko Ishikawa, Morita Iwami
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Publication number: 20180037555Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: ApplicationFiled: February 26, 2016Publication date: February 8, 2018Applicants: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko ISHIKAWA, Morita IWAMI
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Publication number: 20170327513Abstract: Provided are an oxaziridine compound showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, and a production method thereof. A compound represented by the formula 1: wherein X is a single bond, —C(H) (R6)— or —C(H) (R7)—C(H)(R8)—; and R1-R8 are each independently a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, or a salt thereof.Type: ApplicationFiled: January 26, 2017Publication date: November 16, 2017Applicant: SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko ISHIKAWA, Morita IWAMI
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Patent number: 9512075Abstract: The present invention provides compounds belonging to 3-acyloxyindole compounds or 3-acyl-4-hydroxycoumarin compounds, a tautomer or geometric isomer thereof, or a salt thereof and methods for producing the same, which compounds are useful as antibacterial agent and as therapeutic drugs against infectious diseases.Type: GrantFiled: October 17, 2013Date of Patent: December 6, 2016Assignees: OKAYAMA UNIVERSITY, MICROBIAL CHEMISTRY RESEARCH FOUNDATION, KINKI UNIVERSITYInventors: Teruhiko Ishikawa, Tatsuya Kitaoka, Shyota Katayama, Yoshikuni Itoh, Ryutaro Utsumi, Masayuki Igarashi
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Publication number: 20150291523Abstract: The present invention provides compounds belonging to 3-acyloxyindole compounds or 3-acyl-4-hydroxycoumarin compounds, a tautomer or geometric isomer thereof, or a salt thereof and methods for producing the same, which compounds are useful as antibacterial agent and as therapeutic drugs against infectious diseases.Type: ApplicationFiled: October 17, 2013Publication date: October 15, 2015Inventors: Teruhiko Ishikawa, Tatsuya Kitaoka, Shyota Katayama, Yoshikuni Itoh, Ryutaro Utsumi, Masayuki Igarashi
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Patent number: 8524940Abstract: It is possible to produce oseltamivir safely and stably in large quantities by using as a starting material tartaric acid, mannitol or arabinose, via dihydroxyhexenoic acid ester of the formula (4c): (wherein R1, R2 and R6 are same or different and are each alkyl, aryl, substituted aryl, aralkyl, substituted aralkyl or aromatic heterocyclic group, and R1 and R2 are not methyl simultaneously).Type: GrantFiled: December 6, 2011Date of Patent: September 3, 2013Assignee: National University Corporation Okayama UniversityInventors: Teruhiko Ishikawa, Seiki Saito, Takayuki Kudoh, Kotaro Suto, Hironori Nishiuchi, Makoto Okada, Masatoshi Taniguchi
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Publication number: 20120130092Abstract: It is possible to produce oseltamivir safely and stably in large quantities by using as a starting material tartaric acid, mannitol or arabinose, via dihydroxyhexenoic acid ester of the formula (4c).Type: ApplicationFiled: December 6, 2011Publication date: May 24, 2012Inventors: Teruhiko Ishikawa, Seiki Saito, Takayuki Kudoh, Kotaro Suto, Hironori Nishiuchi, Makoto Okada, Masatoshi Taniguchi