Patents by Inventor Teruhiko Oishi
Teruhiko Oishi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11878101Abstract: A blood purification device includes a porous molded body containing an inorganic ion-adsorbing material and is characterized by the following: the concentrations of Mg, Al, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn, Ga, Rb, Sr, Y, Zr, Mo, Ru, Ag, Cd, Sn, Cs, La, Pr, Sm, Gd, Tb, Ta, Au, Tl, Co, In, and Bi are each 0.1 ppb or less and the concentrations of Ba, Nd, Pb, And Ce are each 1 ppb or less in a physiological saline solution for injection both three months and six months after said physiological saline solution for injection is sealed in the blood purification device; and the number of fine particles having a size of 10 ?m or more is 25 or less and the number of fine particles having a size of 25 ?m or more is 3 or less in 1 mL of the physiological saline solution for injection.Type: GrantFiled: March 29, 2019Date of Patent: January 23, 2024Assignee: ASAHI KASEI MEDICAL CO., LTD.Inventors: Teruhiko Oishi, Makoto Ozeki, Keitaro Matsuyama, Naoki Morita, Hiroshi Tajima, Toshinori Koizumi
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Patent number: 11806461Abstract: Provided is a blood purification device including a porous molded body that has a high phosphorus adsorption capacity and that can be used safely. A blood purification device includes a porous molded body containing an inorganic ion-adsorbing material and is characterized by the following: said blood purification device satisfies the relationship B=?0.02 A+2.175±0.185 (74?A?94) when the moisture content of the porous molded body is denoted by A and the bulk density is denoted by B; and the number of fine particles having a size of 10 ?m or more is 25 or less and the number of fine particles having a size of 25 ?m or more is 3 or less in 1 mL of a physiological saline solution for injection both three months and six months after said physiological saline solution for injection is sealed in the blood purification device.Type: GrantFiled: March 29, 2019Date of Patent: November 7, 2023Assignee: ASAHI KASEI MEDICAL CO., LTD.Inventors: Teruhiko Oishi, Naoki Morita, Keitaro Matsuyama, Hiroshi Tajima, Toshinori Koizumi
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Publication number: 20230138912Abstract: Provided are a blood purification system, etc., to enable more achieve more efficient purification of blood. A blood purification system includes a line through which a liquid containing blood or filtrate flows, a blood purification device to purify the blood flowing through the line, a supply device to supply dialysate or replacement fluid to the line, a detector to detect blood information relating to the blood flowing through the line, a liquid control mechanism to control flow of liquid in the line based on control parameters, a parameter acquisition module to input the detected blood information into a learning model trained to output predetermined control parameters when predetermined blood information is input, and acquires control parameters outputted from the learning model, and a control module to control the liquid control mechanism based on the acquired control parameters.Type: ApplicationFiled: March 31, 2021Publication date: May 4, 2023Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventor: Teruhiko OISHI
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Publication number: 20230139818Abstract: Provided are a blood purification system, etc., to enable more achieve more efficient purification of blood. A blood purification system includes a line through which a liquid containing blood or filtrate flows, a plasma separation device to separate a plasma component from blood flowing through the line, a factor separating device to separate a factor component which is a pathogenic factor from the plasma component, a detector to detect blood information relating to blood flowing through the line, a liquid control mechanism to control flow of liquid in the line based on control parameters, a parameter acquisition module to input the detected blood information into a learning model trained to output predetermined control parameters when predetermined blood information is input, and acquire control parameters output from the learning model, and a control module to control the liquid control mechanism based on the acquired control parameters.Type: ApplicationFiled: March 31, 2021Publication date: May 4, 2023Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventor: Teruhiko OISHI
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Publication number: 20230130941Abstract: A closed circulation system test apparatus independently sets the amount of a liquid such as a dialysate for a blood purification device, facilitates management of operations of multiple pumps, and is capable of evaluating performance for removing wastes in blood and lifespan performance of membranes. The closed circulation system test apparatus includes: a blood sending line for sending blood from the blood bag to the blood purification device via a blood pump; a blood returning line for sending blood exiting from the blood purification device to the blood bag via a resistance imparting means; a filtrate line for sending the filtrate exiting from a dialysate outlet of the blood purification device to the replacement fluid container via a filtrate pump; and a dialysate line for sending, via a dialysate pump, dialysate or replacement fluid from the replacement fluid container to a dialysate inlet of the blood purification device.Type: ApplicationFiled: March 31, 2021Publication date: April 27, 2023Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventors: Teruhiko OISHI, Hiroshi UMENO, Hitomi ARAKI
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Publication number: 20220168490Abstract: Provided is a blood purifier which has a porous molded body with good phosphorus adsorption, which has good cytokine adsorption performance, no hemolysis, and can be used safely. The blood purifier has a porous molded body having a low-melting-point moisture content per gram of dry weight of 0.12 g or more and 1.35 g or less. After three and six months from sealing of a saline solution for injection into the blood purifier, the number of microparticles greater than or equal to 10 ?m is 25 or less and the number of microparticles greater than or equal to 25 ?m is three or less in 1 mL of the saline solution for injection.Type: ApplicationFiled: March 27, 2020Publication date: June 2, 2022Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventors: Teruhiko OISHI, Yusuke TOKIMIZU, Keitaro MATSUYAMA, Naoki MORITA
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Publication number: 20220111133Abstract: A blood purifier includes a porous molded body; exhibits an excellent blood compatibility wherein platelet adherence is inhibited and exhibits a good cytokine adsorption capacity and a low pressure loss before and after blood treatment; and can be safely used. A blood purifier includes a main vessel and a porous molded body housed in the main vessel. The porous molded body contains a hydrophobic polymer and a hydrophilic polymer. The amount of low-melting-point water per 1 g of dry weight of the porous molded body is 0.12 g to 2.00 g. The contact change ratio for the porous molded body is 0% to 0.2%. The ratio L/D is 1.00 to 2.30 where, for the region taken up by the porous molded body in the main vessel, L is the length in the flow direction and D is the circle-equivalent diameter of the cross section in the direction perpendicular to the flow direction.Type: ApplicationFiled: March 27, 2020Publication date: April 14, 2022Applicant: Asahi Kasei Medical Co., Ltd.Inventors: Teruhiko OISHI, Yusuke TOKIMIZU, Keitaro MATSUYAMA, Naoki MORITA
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Publication number: 20220105454Abstract: Provided is a blood purifier which includes a porous formed body and which has excellent blood compatibility, in which platelets are unlikely to adhere, has good cytokine adsorption capacity, and low pressure loss before and after treating blood, and can be safely used. Disclosed is a blood purifier having a body container, and a porous formed body accommodated in the body container. The porous formed body contains a hydrophobic polymer and a hydrophilic polymer, the low-melting-point water content per 1 g of dry weight of the porous formed body is 0.12-2.00 g, the rate of contact change of the porous formed body is 0-0.2%, and the adhering amount of platelets per 1 mL of blood is 0.400 billion/mL or less when brining the blood into contact with the porous formed body.Type: ApplicationFiled: March 27, 2020Publication date: April 7, 2022Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventors: Teruhiko OISHI, Yusuke TOKIMIZU, Keitaro MATSUYAMA, Naoki MORITA
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Publication number: 20220062522Abstract: An extracorporeal blood circulation device is provided with: a blood component adjuster; a blood purification device; a pipe system provided with a pump for supplying blood from a blood collecting part to the blood component adjuster, a valve for supplying a physiological saline solution, and a pressure gauge for sensing a pressure loss; a bypass pipe system for bypassing the blood component adjuster and supplying blood to the blood purification device; a pipe system for connecting the blood component adjuster and the blood purification device, the pipe system being provided with a pressure gauge for sensing a pressure loss; a pipe system provided with a valve for returning blood from the blood purification device to a reinfusion part and recovering the physiological saline solution, and a pressure gauge for sensing a pressure loss; and a control unit for switching to the bypass pipe system and switching to a reinfusion mode.Type: ApplicationFiled: December 18, 2019Publication date: March 3, 2022Applicant: Asahi Kasei Medical Co., Ltd.Inventors: Teruhiko OISHI, Naoki MORITA, Makoto OZEKI, Toshinori KOIZUMI
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Publication number: 20210353845Abstract: Provided is a blood purification device including a porous molded body that has a high phosphorus adsorption capacity and that can be used safely. A blood purification device includes a porous molded body containing an inorganic ion-adsorbing material and is characterized by the following: said blood purification device satisfies the relationship B=?0.02 A+2.175±0.185 (74?A?94) when the moisture content of the porous molded body is denoted by A and the bulk density is denoted by B; and the number of fine particles having a size of 10 ?m or more is 25 or less and the number of fine particles having a size of 25 ?m or more is 3 or less in 1 mL of a physiological saline solution for injection both three months and six months after said physiological saline solution for injection is sealed in the blood purification device.Type: ApplicationFiled: March 29, 2019Publication date: November 18, 2021Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventors: Teruhiko OISHI, Naoki MORITA, Keitaro MATSUYAMA, Hiroshi TAJIMA, Toshinori KOIZUMI
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Publication number: 20210008270Abstract: A blood purification device includes a porous molded body containing an inorganic ion-adsorbing material and is characterized by the following: the concentrations of Mg, Al, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn, Ga, Rb, Sr, Y, Zr, Mo, Ru, Ag, Cd, Sn, Cs, La, Pr, Sm, Gd, Tb, Ta, Au, Tl, Co, In, and Bi are each 0.1 ppb or less and the concentrations of Ba, Nd, Pb, And Ce are each 1 ppb or less in a physiological saline solution for injection both three months and six months after said physiological saline solution for injection is sealed in the blood purification device; and the number of fine particles having a size of 10 ?m or more is 25 or less and the number of fine particles having a size of 25 ?m or more is 3 or less in 1 mL of the physiological saline solution for injection.Type: ApplicationFiled: March 29, 2019Publication date: January 14, 2021Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventors: Teruhiko OISHI, Makoto OZEKI, Keitaro MATSUYAMA, Naoki MORITA, Hiroshi TAJIMA, Toshinori KOIZUMI
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Patent number: 7563376Abstract: A plasma purification membrane and a plasma purification system for treating diseases. The above plasma purification membrane is a hollow fiber plasma purification membrane being made of a hydrophobic polymer and a hydrophilic polymer and having a sponge-like structure wherein the pore size is continuously decreased from the outer surface of the membrane toward the inner surface thereof, characterized in that the break strength of the membrane is 50 kgf/cm2 or more and, in the case of the inner pressure filtration of bovine plasma, the total protein permeability is 50% or more while the immunoglobulin (IgM) permeability is 90% or less.Type: GrantFiled: September 12, 2003Date of Patent: July 21, 2009Assignee: Asahi Kasei Kuraray Medical Co., Ltd.Inventor: Teruhiko Oishi
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Patent number: 7156240Abstract: A filter for reducing leukocytes and platelets from an erythrocyte preparation or a whole blood preparation which is characterized by having a filter base coated with a polymer, the content of the polymer being from 0.5 to 10 mg/m2 per unit area of the total surface of the filter base, and the polymer containing 20% or less of low-molecular weight components having a molecular weight not more than ¼ of the peak top molecular weight in the gel permeation chromatogram.Type: GrantFiled: January 29, 2002Date of Patent: January 2, 2007Assignee: Asahi Kasei Medical Co., Ltd.Inventors: Teruhiko Oishi, Morikazu Miura
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Patent number: 7087168Abstract: It is intended to provide a blood purification membrane having excellent performance and showing little elution of blood and little adhesion of blood proteins or platelets. The above object can be achieved by using a moisten membrane, which is free from any membrane pore-sustaining agent and has a high water permeation dose and a large pore size, and lessening the pore size by drying the membrane after desolvation.Type: GrantFiled: July 24, 2002Date of Patent: August 8, 2006Assignee: Asahi Kasei Medical Co., Ltd.Inventors: Teruhiko Oishi, Tomoji Hanai
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Publication number: 20060108288Abstract: A plasma purification membrane and a plasma purification system for treating diseases. The above plasma purification membrane is a hollow fiber plasma purification membrane being made of a hydrophobic polymer and a hydrophilic polymer and having a sponge-like structure wherein the pore size is continuously decreased from the outer surface of the membrane toward the inner surface thereof, characterized in that the break strength of the membrane is 50 kgf/cm2 or more and, in the case of the inner pressure filtration of bovine plasma, the total protein permeability is 50% or more while the immunoglobulin (IgM) permeability is 90% or less.Type: ApplicationFiled: September 12, 2003Publication date: May 25, 2006Inventor: Teruhiko Oishi
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Patent number: 6977044Abstract: A filter for selectively removing leukocytes from the human whole blood, characterized in that it comprises a filter base coated with a hydrophilic synthetic polymer having a weight-average molecular weight of 300,000 to 3,000,000 and that the percentage of covering by the polymer is 70% or higher based on the whole surface of the filter base.Type: GrantFiled: November 1, 2000Date of Patent: December 20, 2005Assignee: Asahi Medical Co., Ltd.Inventors: Teruhiko Oishi, Morikazu Miura, Tatsuya Fukuda, Hirofumi Miura
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Publication number: 20040206692Abstract: It is intended to provide a blood purification membrane having excellent performance and showing little elution of blood and little adhesion of blood proteins or platelets. The above object can be achieved by using a moisten membrane, which is free from any membrane pore-sustaining agent and has a high water permeation dose and a large pore size, and lessening the pore size by drying the membrane after desolvation.Type: ApplicationFiled: May 19, 2004Publication date: October 21, 2004Inventors: Teruhiko Oishi, Tomoji Hanai
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Publication number: 20040104165Abstract: A filter for reducing leukocytes and platelets from an erythrocyte preparation or a whole blood preparation which is characterized by having a filter base coated with a polymer, the content of the polymer being from 0.5 to 10 mg/m2 per unit area of the total surface of the filter base, and the polymer containing 20% or less of low-molecular weight components having a molecular weight not more than ¼ of the peak top molecular weight in the gel permeation chromatogram.Type: ApplicationFiled: January 9, 2004Publication date: June 3, 2004Inventors: Teruhiko Oishi, Morikazu Miura
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Publication number: 20010047959Abstract: A polyacrylonitrile-based hollow fiber filtration membrane, wherein said membrane comprises a sponge structure free from polymer defect sites of sizes larger than 10 &mgr;m inside the membrane, pore sizes of the membrane continuously decrease towards both surfaces of the membrane, and the pore size on the outer surface of the membrane is differentiated from that on the inner surface.Type: ApplicationFiled: June 25, 2001Publication date: December 6, 2001Applicant: Asahi Kasei Kabushiki KaishaInventors: Teruhiko Oishi, Noboru Kubota
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Patent number: 6165363Abstract: A hollow fiber filter membrane where the inner surface comprises a three-dimensional network structure having thick trunks of 10-30 .mu.m in maximum diameter and the average pore diameter of a minimum pore diameter layer of the membrane is 0.01 .mu.m or more and less than 1 .mu.m.Type: GrantFiled: June 18, 1998Date of Patent: December 26, 2000Assignee: Asahi Kasei Kogyo Kabushiki KaishaInventors: Teruhiko Oishi, Hiroyoshi Ohya