Abstract: A mouse CDNA encoding a protein comprising a serine/threonine protein kinase region was isolated by effecting PCR using a synthetic DNA corresponding to the kinase-conserved region as a primer and a rat cDNA as a template. A mouse cDNA library was screened using the DNA fragment thus obtained as a probe. The multiple human and mouse cDNAs having the similar structure to the isolated mouse cDNA were successfully isolated based on the sequence of the isolated mouse cDNA. An antisense DNA against the isolated mouse cDNA was synthesized, and its effect on a nerve cell was studied to confirm that the antisense DNA inhibits axonal elongation.

Abstract: A precursor of a C-terminal amidated peptide represented by the general formula P-X-Gly-Y.sub.n, wherein P is a peptide residue. X is an amino acid residue the C terminal of which (on the Gly side) can be converted in vivo to a --CONH.sub.2 group. Gly is a glycine residue, Y is a basic amino acid residue, n is an interger of 2 to 4 and a further amino acid residue other than Y or a peptide residue may be attached to Y.sub.n, is produced by a gene engineering technology. The precursor exhibits in vivo physiological activity like the C-terminal amidated peptide.

Abstract: A novel cell line for use as a parent for hybridoma preparation is provided. This cell line is derived from tumor cells, in particular human tumor cells, other than those originating from bone marrow cells. A method for establishing this cell line is also provided. By fusing this cell line with cells producing useful physiologically active substances, such as B cells immunized with an antigen, a hybridoma capable of active growth can be prepared. This hybridoma can be cultivated for the production of useful physiologically active substances.

Abstract: A robot having a robot arm swingable from a position outside a car body conveying line to the line and movable in the directions of length, width and height of the car body is provided with a support frame carrying a jig for holding the window glass. The frame is tiltably mounting on the arm via a tilting shaft. A first detector is mounted on the frame for detecting a deviation the car-width direction of the jig with respect to the window portion. A pair of second detectors are provided on the frame at positions which are symmetrical with respect to the car width direction center line of the jig for detecting deviations in the plane of the window opening. First, deviation detected by the first detector is corrected by moving the jig in the car width direction. Then, deviation in tilt detected by the second detectors is corrected by tilting the jig. Finally, deviation in height detected jointly by the second detectors is corrected by raising or lowering the jig.

Abstract: Antitumor protein hybrid, composed of a moiety which is substantially the fragment Fab of an antitumor immunoglobulin and a moiety which is substantially the fragment A of a diphtheria toxin, which is expressed by the following formula (I):Fab--S.sub.1 --(X).sub.n --S.sub.2 --FA).sub.m (I)(where Fab indicates a moiety which is substantially the fragment Fab of an antitumor immunoglobulin; FA indicates a moiety which is substantially the fragment A of a diphtheria toxin; X indicates a divalent organic radical; S.sub.1 and S.sub.2 are both sulfur atoms, S.sub.1 indicating a sulfur atom arising from the disulfide bond (--S--S-- bond) in an immunoglobulin and S.sub.2 a sulfur atom arising from the disulfide bond in a diphtheria toxin; n stands for 0 to 1 and m stands for an integer of 1 to 5). This antitumor protein hybrid has remarkable and specific cytotoxicity against tumor cells, e.g., in mice.

Abstract: Fungicidal compositions are provided containing as the active constituent compounds having the formula: ##STR1## wherein each of R and R.sub.1 represents a member of the group consisting of alkyl containing from 1 to 12 carbon atoms, alkyl containing from 1 to 2 carbon atoms substituted with halogen, methoxy or phenyl, alkenyl containing 2 to 3 carbon atoms, alkynyl containing 2 to 3 carbon atoms, aryl containing not more than 10 carbon atoms, aryl containing not more than 10 carbon atoms substituted with halogen or methyl; each X represents halogen, nitro or methyl; n represents an integer from 0 to 3; and Y represents oxygen or sulfur, with the proviso that when Y represents sulfur, each R and R.sub.1 represents alkyl containing 1 to 12 carbon atoms.These compounds may be prepared in accordance with the following equation: ##STR2## wherein R, R.sup.1, X, Y and n are as stated above. These compounds have broad fungicidal activity with very low mammalian toxicity.

Abstract: Compounds having the formula: ##STR1## wherein each of R and R.sub.1 represents a member of the group consisting of alkyl containing from 1 to 12 carbon atoms, alkyl containing from 1 to 2 carbon atoms substituted with halogen, methoxy or phenyl, alkenyl containing 2 to 3 carbon atoms, alkynyl containing 2 to 3 carbon atoms, aryl containing not more than 10 carbon atoms, aryl containing not more than 10 carbon atoms substituted with halogen or methyl; each X represents halogen, nitro or methyl; and n represents an integer from 0 to 3. These compounds may be prepared in accordance with the following equation: ##STR2## wherein R, R.sup.1, X and n are as stated above. These compounds have broad fungicidal activity with very low mammalian toxicity.

Abstract: The compounds of the general formula: ##STR1## wherein R.sub.1 is alkyl of 1 through 4 carbon atoms,R.sub.2 is cyclopropyl or phenyl; have fungicidal and acaricidal activities.