Patents by Inventor Terukatsu Arima

Terukatsu Arima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assay for Non-A Non-B hepatitis
    Patent number: 5635346
    Abstract: New assays for diagnosing NANBH utilizing novel peptide fragments derived from polypeptide antigens reactive to antibodies present in the sera of infected patients are disclosed. In producing these peptides, the portion of the polypeptide contributing to high backgrounds is deleted thereby resulting in assays with an exceptionally high signal to background ratio.
    Type: Grant
    Filed: January 17, 1995
    Date of Patent: June 3, 1997
    Assignee: Dade International Inc.
    Inventors: David C. Leahy, John A. Todd, Michael E. Jolley, Dinesh O. Shah, Delia R. Bethell, Terukatsu Arima
  • DNA sequence and encoded polypeptide useful in the diagnosis of hepatitis disease
    Patent number: 5437974
    Abstract: A novel cDNA clone, 20E, has been isolated and characterized as encoding a previously unknown polypeptide antigen recognized by antibodies in the serum of certain patients with non-A non-B hepatitis (NANBH). The nucleic acid sequence is not represented in the genome of the Hepatitis C Virus (HCV). Neither is the nucleic acid sequence represented in the human genome. The data suggest that the RNA sequence corresponding to clone 20E is contained within the genome of an external infective agent other than HCV, and therefore may represent an additional etiologic agent or contributing factor to the development of NANBH in human patients. The 20E nucleic acid and corresponding polypeptide and respective variants thereof will be useful in a variety of procedures directed at prevention and diagnosis of NANBH.
    Type: Grant
    Filed: February 4, 1992
    Date of Patent: August 1, 1995
    Assignee: Dade International Inc
    Inventors: Terence E. Ryan, Badr Saeed, Mark K. Kieselburg, Robert E. Byrne, Priscilla W. Stevens, Terukatsu Arima, John Todd
  • Non-A, non-B hepatitis virus antigen peptide
    Patent number: 5298394
    Abstract: Disclosed is a non-A, non-B hepatitis virus antigen peptide which exhibits antigen-antibody reaction specificity with at least one of sera from a convalescent patient having acute non-A, non-B hepatitis and sera from a patient having chronic non-A, non-B hepatitis. By the use of the antigen peptide of the present invention, not only the diagnosis of non-A, non-B hepatitis but also the screening of blood for transfusion can be achieved with ease and high reliability. The antigen peptide of the present invention may also be used as the basis for a vaccine against non-A, non-B hepatitis.
    Type: Grant
    Filed: March 2, 1993
    Date of Patent: March 29, 1994
    Assignee: The Research Foundation for Microbial Diseases
    Inventors: Terukatsu Arima, Konosuke Fukai
  • Non-A, non-B hepatitis virus antigen peptide
    Patent number: 5275947
    Abstract: Disclosed is a non-A, non-B hepatitis virus antigen peptide which exhibits antigen-antibody reaction specificity with at least one of sera from a convalescent patient having acute non-A, non-B hepatitis and sera from a patient having chronic non-A, non-B hepatitis. By the use of the antigen peptide of the present invention, not only the diagnosis of non-A, non-B hepatitis but also the screening of blood for transfusion can be achieved with ease and high reliability. The antigen peptide of the present invention may also be used as the basis for a vaccine against non-A, non-B hepatitis.
    Type: Grant
    Filed: March 2, 1993
    Date of Patent: January 4, 1994
    Assignee: The Research Foundation for Microbial Disease of Osaka University
    Inventors: Terukatsu Arima, Konosuke Fukai
  • Peptide and its use
    Patent number: 5247067
    Abstract: The present invention relates to a peptide having the amino acid sequence: Lys Arg Ser Thr Asn, Arg Arg Tyr Lys Glu Lys Glu Lys or Ala Ile Ile Pro Asp Arg Glu Val Leu Tyr and which peptide is capable of specifically binding to the antibody which is specific to the non-A, non-B hepatitis associated antigen. The peptide can be used as an anti-HCV antibody assay reagent with high sensitivity.
    Type: Grant
    Filed: March 8, 1991
    Date of Patent: September 21, 1993
    Assignees: Kuraray Co., Ltd., Terukatsu Arima
    Inventors: Terukatsu Arima, Kyoko Yamada, Tadashi Hatanaka, Toshihiko Namba, Masao Tsuji
  • Peptides immunochemically reactive with antibodies directed against hepatitis Non-A, Non-B virus
    Patent number: 5229491
    Abstract: The invention concerns peptides which react immunochemically with antibodies directed against NANBH. A method for the detection of NANBH or anti-NANBH in a test fluid, an immunochemical reagent and a testkit to be used when applying said detection methods belong to the invention.
    Type: Grant
    Filed: March 28, 1991
    Date of Patent: July 20, 1993
    Assignee: AKZO NV
    Inventors: Winand J. A. Habets, Terukatsu Arima, Pieter J. Boender
  • Non-A, non-B hepatitis virus antigen peptide
    Patent number: 5191064
    Abstract: Disclosed is a non-A, non-B hepatitis virus antigen peptide which exhibits antigen-antibody reaction specificity with at least one of sera from a convalescent patient having acute non-A, non-B hepatitis and sera from a patient having chronic non-A, non-B hepatitis. By the use of the antigen peptide of the present invention, not only the diagnosis of non-A, non-B hepatitis but also the screening of blood for transfusion can be achieved with ease and high reliability. The antigen peptide of the present invention may also be used as the basis for a vaccine against non-A, non-B hepatitis.
    Type: Grant
    Filed: August 31, 1989
    Date of Patent: March 2, 1993
    Assignee: The Research Foundation for Microbial Diseases (Osaka University)
    Inventors: Terukatsu Arima, Konosuke Fukai