Abstract: A medical device is configured to prevent a member attached to the distal end of an operation wire passing through a catheter from dropping out from an operation wire. The medical device includes an operation wire which passes through a catheter and which is advanceable and retractable toward the axial direction with respect to the catheter, a distal member interlocked on the distal side of the operation wire, and a grasping unit which is interlocked on the proximal side of the operation wire. The medical device also includes a safety mechanism for releasing the interlock between the operation wire and the grasping unit by a load lower than the breaking strength between the operation wire and the distal member.

Abstract: An applicator insertable into a living body includes a nozzle having an elongated nozzle main body and a nozzle head on a front end side of the nozzle main body and through which liquid together with gas is expelled, with the nozzle main body including a flexible curved section. The applicator also includes an outer tube in which is positioned a portion of the nozzle main body so as to be movable along a longitudinal direction. The angle or degree of curvature of the curved section is changed by inserting the curved section into the outer tube to thereby adjust the direction of the nozzle head relative to the axis of the nozzle main body. In addition, a longitudinally extending gap exists between the outer tube and the nozzle. The gap functions as a discharge path for discharging the gas within the body cavity.

Abstract: A tubular sensor includes a tubular body having a longitudinally extending cavity, an insulation layer formed on the inner wall surface of the tubular body; and a plurality of longitudinally extending electrodes formed on the insulation layer and extending continuously from one end to the other end of the tubular body. The tubular sensor can be employed in a constituent measuring device. The tubular sensor can be manufactured by forming the insulation layer on a thin metal sheet, forming the plurality of electrodes on the insulation layer in stripes, cutting the thin metal sheet with the insulation layer and the electrodes formed thereon to produce a plate-shaped body having a development shape of the tubular body, and press working the plate-shaped body to form the tubular body.

Abstract: A flexible tube for medical instrument includes tubular bodies, one of the tubular bodies relatively turnably connected to an adjacent one of the tubular bodies by a hinge structure. Each of the tubular bodies includes a pivotal section provided at a connecting-directionally first end edge forming the hinge structure, a turning support section provided at a connecting-directionally second end edge and supporting the pivotal section of the one of tubular bodies connected to the adjacent one of tubular bodies, a projection which is provided at either one of the first and second end edges, and is projected in the connecting direction from a position different from the position of the pivotal section or the turning support section, and a recess provided at the other of the first and second end edges and engaged with the projection of the one of tubular bodies connected to the adjacent one of tubular bodies.

Abstract: To provide a biological adhesive sheet which is reduced in the influence on living tissue and thus has improved safety. A biological adhesive sheet includes a substrate formed of a biocompatible material; and a plurality of projections that are formed of a biocompatible material and configured so as to protrude from the surface of the substrate. The biological adhesive sheet is bonded to living tissues by the van der Waals force by having the plurality of projections in contact with the living tissues.

Abstract: Disclosed herein is an expansion catheter including: an expansion body which can be expanded; an elongate main body to a distal section of which the expansion body is attached; and an imaging section by which the expansion body is imaged from a proximal side thereof.

Abstract: Provided is a puncture needle for injecting bone cement, comprising a side-port-forming member embedded into an outer needle base. The outer needle base is formed by insert molding. The side-port-forming member covers the circumference of a second side hole, and provides communication between the second side hole and the outside of the outer needle base. The method for producing the puncture needle for injection of bone cement comprises affixing the side-port-forming member to the basal end part of a double-tube member, and subsequently forming, by insert molding, an outer needle base for covering the side-port-forming member as well as the basal end part of the double-tube member.

Abstract: A liposome composition into which a drug can be introduced in a high encapsulation amount, which has sustained release properties to such an extent that an effective concentration can be maintained at a clinically satisfactory level, and which is suitable for subcutaneous administration or the like. The liposome composition includes: a first liposome which has an outer membrane composed of a multilayered lipid bilayer; and a plurality of second liposomes which are accommodated in a first liposome inner region defined by the outer membrane and each of which has an outer membrane composed of a lipid bilayer. The lipid bilayer of the second liposomes can be multilayered. The liposome composition has second liposome inner regions each defined by the outer membrane of each of the second liposomes. An ion gradient is formed at least between each of the second liposome inner regions and the outside of the first liposome.

Abstract: The catheter includes a hollow shaft, at least one adhering portion provided on an outer surface of the shaft, and plural protrusions arranged on the adhering portion. The protrusions are configured to increase a contact surface area to show adhesive strength due to a Van der Waals force.

Abstract: An object of the present invention is to provide a syringe for prefilled syringe in which the adsorption of a low-molecular medical agent or a protein for a long term is precluded. In accordance with the present invention, the above-described object is achieved by a syringe for prefilled syringe including: a plunger in which a gasket is attached to a top; and a syringe barrel in which the plunger is slidably accommodated, wherein the surface of the gasket and the inner wall of the syringe barrel are subjected to surface modification with a polymer containing zwitterion.

Abstract: A luminal cavity closing device can include a flexible linear shaft, a clamping mechanism which is provided at a distal portion of the shaft and has at least two arms, and a detachment mechanism configured to enable detachment of the clamping mechanism from the shaft. The arms of the clamping mechanism can be configured so as to be insertable into hollow tubular structures located adjacent to and on both sides of a luminal cavity present in a hollow tubular structure bifurcation area. The clamping mechanism operates between an expanded state wherein the interval of the arms is enlarged to a contracted state wherein the interval of the arms is contracted.

Abstract: An indwelling device delivery system including a hollow shaft, a dilatable balloon mounted on a circumference of a distal part of the shaft, and an indwelling device mounted on a circumference of the balloon and expanded by dilatation of the balloon. The balloon has a plurality of protrusions for adhering to the indwelling device and the protrusions are constructed so as to elicit adhesion force based on physical adhesion due to van der Waals force by means of creating more surface area.

Abstract: A luminal cavity closing device can include a flexible shaft, a lid member, and a detachment mechanism. The flexible shaft extends in an axial direction. The lid member which is attached to a distal end of the shaft, can be rotated according to a torque transmitted from the shaft. Thus, a lock section can be thrust into a periphery of an opening of a luminal cavity formed in a living body lumen, to thereby lock the lid member to the periphery. The detachment mechanism can be configured to detachably attach the lid member to the shaft. The torque can be transmitted to the lid member, and the shaft can be detached from the lid member by the detachment mechanism while the lid member is locked to the periphery of the opening of the luminal cavity.

Abstract: A means for restraining hardening of silicone rubber is provided. In one form, a silicone rubber composition is provided that contains an antioxidant dispersed therein. In addition, a method for preparing the silicone rubber composition is provided that includes: a step of mixing a silicone rubber precursor and the antioxidant and curing the obtained mixture; or a step of wetting the silicone rubber with a liquid antioxidant. A method of manufacturing a medical device is also provided, including: a step of incorporating into a medical device the silicone rubber composition obtained in the preparation method outlined above; a step of seal packaging the obtained medical device; and a step of irradiating the seal-packaged medical device with radiation.

Abstract: A catheter set includes a catheter and a fixing device. The fixing device includes a tubular member which is formed in such a way as to increase or decrease in diameter under axial extension or compression. A first projection and a second projection are provided at both ends of the tubular member. A movable tubular body is disposed around the tubular member between the first projection and the second projection. A distal part is coupled to the tubular member by a support member. The distal part is disposed distally of the tubular member and is configured to at least contact a proximal portion of a tubular device for medical use through which the catheter runs.

Abstract: A balloon including a laminated film of at least two layers including a polyamide elastomer layer and a polyamide layer wherein the polyamide elastomer layer is formed at the inner side of the polyamide layer and a molecular weight distribution of the polymers as a whole of the balloon (weight-average molecular weight Mw/number-average molecular weight Mn) ranges from 3 to 10.

Abstract: A placement device for a blood vessel treatment instrument has an introducer sheath functioning as an outer tube, and also has an inner tube. The introducer sheath has a flexible tube-shaped sheath body and a hub into which the base end of the sheath body is inserted. The hub takes-up the base end of the sheath body into the hub by way of take-up shafts while slitting the base end of the sheath body by cutting blades, and thus the length of extension of the sheath body from the hub can be shortened.

Abstract: A hemostatic device includes a flexible band adapted to be wrapped around a patient's limb at a site on the limb where bleeding is to be stopped, a portion for securing the band in a wrapped state to the limb, a curved plate which is made of a material more rigid than the band and at least a portion of which is curved toward the inner peripheral side thereof, a main balloon which is provided on the inner peripheral side of the curved plate and which inflates when a fluid is introduced therein, and a pressing member which is provided between the curved plate and the main balloon so that at least a portion thereof overlaps with the balloon and which is adapted for pressing against the balloon. The device provides an excellent hemostatic effect and prevents numbness and poor circulation in areas peripheral to the site of attachment.

Abstract: A medical treatment device enables an injection needle to accurately puncture brain tissue at a prescribed position and a drug solution to be injected into brain tissue, while avoiding damage to the brain tissue as the injection needle is handled. The use of the medical treatment device involves inflating a first balloon located on the outside of a catheter, directing a distal portion of a puncture needle, which is located inside the catheter, to outside the catheter through an opening in the catheter, after which the first balloon is deflated and a second balloon is inflated, and moving the catheter towards the brain tissue located on the opening side so that the injection needle projecting from the opening punctures the brain region.

Abstract: The present invention provides a method for treatment of emphysema, including: (a) a step of inserting and placing first through-hole forming means in emphysematous lung area, forming a first through-hole in the emphysematous lung area by puncture, and, after contact of the first through-hole forming means with pleura, detaching the pleura from the lung area to form a detachment space; (b) a step of inserting and placing second through-hole forming means in normal lung area, and forming a second through-hole in the lung area by puncture; and (c) a step of causing the first through-hole and the second through-hole to communicate with each other through the detachment space formed in the step (a).