Patents by Inventor Teruo Okano

Teruo Okano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10717961
    Abstract: A cell culture system having a cell culture vessel, a composition controlling fluid storage vessel, a culture fluid composition controlling means having an inlet and an outlet for a cell culture fluid, an inlet-connected fluid feeding circuit from the cell culture vessel to the inlet of the culture fluid composition controlling means, an outlet-connected fluid feeding circuit from the cell culture vessel to the outlet of the culture fluid composition controlling means, a means which perfuses the cell culture fluid from the inlet-connected fluid feeding circuit to the outlet-connected fluid feeding circuit through the culture fluid composition controlling means, and a means which controls the amount of fluid in the cell culture vessel, in which compositions of the cell culture fluid in the cell culture vessel and compositions of the composition controlling fluid in the composition controlling fluid storage vessel can be controlled in a continuous manner.
    Type: Grant
    Filed: April 24, 2013
    Date of Patent: July 21, 2020
    Assignees: ASAHI KASEI KABUSHIKI KAISHA, TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Ushio Iwamoto, Michi Sato, Kanako Konishi, Katsuhisa Matsuura, Tatsuya Shimizu, Teruo Okano
  • Patent number: 10688133
    Abstract: The present invention provides a method of inhibiting progression of or preventing renal disorder, the method comprising applying a cell sheet composition for inhibiting progression of or preventing renal disorder to at least one part of the surface of a kidney, wherein the part of the surface is uncovered by a fibrous capsule of the kidney. The present invention also provides a cell sheet composition for inhibiting progression of or preventing renal disorder, the cell sheet composition comprising a cell that has a function of producing a hepatocyte growth factor (HGF). The present invention also provides a method of producing a cell sheet composition for inhibiting progression of or preventing renal disorder.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: June 23, 2020
    Assignee: TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Masatoshi Oka, Sachiko Sekiya, Tatsuya Shimizu, Kosaku Nitta, Teruo Okano
  • Patent number: 10603410
    Abstract: A complex of implant and cultured periodontal ligament cell sheet, that can be satisfactorily stabilized into the bone through periodontal ligament tissue, is provided. A fixture of the inserted implant is coated with calcium phosphate and the cultured periodontal ligament cell sheet is brought into intimate contact with the implant.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: March 31, 2020
    Assignees: GENERAL INC.
    Inventors: Kaoru Washio, Isao Ishikawa, Teruo Okano, Takao Hanawa, Yusuke Tsutsumi, Yuka Tsumanuma, Supreda Suphanantachat, Kosei Yano
  • Patent number: 10434219
    Abstract: A diseased site where an anterior segment tissue is partly or entirely damaged or deficient can be treated using a corneal epithelium forming cell sheet that will adhere well to the anterior segment tissue. To attain this objective, a corneal epithelium forming cell sheet is produced by a process comprising the steps of cultivating under specified conditions corneal epithelium forming cells on a cell culture support comprising a substrate having its surface covered with a temperature responsive polymer of which the hydrating force varies in a temperature range of 0° C.-80° C., optionally stratifying the layer of cultured cells, and thereafter, (1) adjusting the temperature of the culture solution to either above an upper critical dissolution temperature or below a lower critical dissolution temperature, (2) bringing the cultured corneal epithelium forming cells into close contact with a carrier, and (3) detaching the sheet together with the carrier under specified conditions.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: October 8, 2019
    Assignees: CELLSEED INC.
    Inventors: Teruo Okano, Kohji Nishida, Masayuki Yamato
  • Patent number: 10368980
    Abstract: The purpose of the present invention is to obtain an alternative to a substitute of the mucosa in the middle ear which is engrafted on the surface of the bone in the middle ear, hyperplasia of the granulation tissue and the bone and the development of the fibroblast cells in the middle ear are suppressed, and to obtain a middle ear mucosa-like cell sheet retaining cilia in the surface layer, comprising culturing nasal epithelium cells on a cell culture substrate coated with a polymer whose hydration force changes within a temperature range of 0 to 80° C., wherein the cells are cultured within a temperature range where the hydration force of the polymer is weak, and then changing the temperature to a temperature at which the hydration force is strong to recover the cultured cell sheet.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: August 6, 2019
    Assignees: Tokyo Women's Medical University, The Jikei University, CellSeed Inc.
    Inventors: Takanori Hama, Hiromi Kojima, Hiroshi Moriyama, Masayuki Yamato, Teruo Okano
  • Patent number: 10251916
    Abstract: An object of the present invention is to provide a cell composition for treatment of uterine tissue that heals damage occurring in uterine tissue, including intrauterine adhesion, to a state that enables pregnancy. In addition, an object of the present invention is to provide a method for producing this cell composition for treatment of uterine tissue, and a cell composition for treatment of uterine tissue produced according to that method. The cell composition, which has a first cell layer containing epithelial cells and a second cell layer containing stromal cells, and the first cell layer is laminated on the second cell layer, has the ability to heal damage occurring in uterine tissue, including intrauterine adhesion, and restore it to a state that enables pregnancy.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: April 9, 2019
    Assignee: TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Goro Kuramoto, Soichi Takagi, Tatsuya Shimizu, Teruo Okano
  • Publication number: 20190054123
    Abstract: The present invention addresses the problem of providing a cell sheet composition for healing or preventing discharge from a wounded region of a luminal organ. The present invention also addresses the problem of providing a method in which the cell sheet composition is affixed to a wounded region of a luminal organ to heal or prevent discharge from the wounded region of the luminal organ. The present invention provides a cell sheet composition including mesenchymal stem cells which is characterized by being affixed to a wounded region of a luminal organ in order to heal or prevent discharge from the wounded region of the luminal organ. The present invention also provides a method in which the cell sheet composition including mesenchymal stem cells is affixed to a wounded region of a luminal organ to heal or prevent discharge from the wounded region of the luminal organ.
    Type: Application
    Filed: January 17, 2017
    Publication date: February 21, 2019
    Applicant: TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Nobuo Kanai, Yasuhiro Maruya, Kurodo Koshino, Masanori Maeda, Teruo Okano
  • Patent number: 10094816
    Abstract: Provided is a means for evaluating the wetting characteristic of an object such as a cell sheet and a culture dish in a non-contact fashion. The wetting characteristic of an object is evaluated by a method comprising the steps of: (1) removing a liquid by jetting a gas at a surface of the object covered with the liquid, (2) measuring a dimension of a region in which the liquid is removed after the completion of the gas jetting and (3) evaluating the wetting characteristic of the object using the measured dimension as an index.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: October 9, 2018
    Assignee: TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Nobuyuki Tanaka, Ryohei Uchida, Makoto Kondo, Masayuki Yamato, Teruo Okano, Makoto Kaneko
  • Patent number: 9981064
    Abstract: An improved process for producing a regenerated corneal endothelial cell sheet, comprising the steps of allowing corneal endothelial cells collected from a tissue to be cultivated on a cell culture support having its surface covered with a polymer of which the hydrating force varies in a temperature range of 0-80° C., and after the culture, (1) adjusting the temperature of the culture solution to the temperature at which the polymer on the substrate surface is hydrated, (2) bringing the cultured corneal endothelial cell sheet into close contact with a carrier, and (3) detaching the sheet together with the carrier. The regenerated corneal endothelial cell sheet obtained by the process will adhere very well to living tissues.
    Type: Grant
    Filed: February 20, 2004
    Date of Patent: May 29, 2018
    Assignees: CELLSEED INC.
    Inventors: Teruo Okano, Kohji Nishida, Masayuki Yamato
  • Publication number: 20180126040
    Abstract: A diseased site where an anterior segment tissue is partly or entirely damaged or deficient can be treated using a corneal epithelium forming cell sheet that will adhere well to the anterior segment tissue. To attain this objective, a corneal epithelium forming cell sheet is produced by a process comprising the steps of cultivating under specified conditions corneal epithelium forming cells on a cell culture support comprising a substrate having its surface covered with a temperature responsive polymer of which the hydrating force varies in a temperature range of 0° C.-80° C., optionally stratifying the layer of cultured cells, and thereafter, (1) adjusting the temperature of the culture solution to either above an upper critical dissolution temperature or below a lower critical dissolution temperature, (2) bringing the cultured corneal epithelium forming cells into close contact with a carrier, and (3) detaching the sheet together with the carrier under specified conditions.
    Type: Application
    Filed: December 29, 2017
    Publication date: May 10, 2018
    Inventors: Teruo OKANO, Kohji NISHIDA, Masayuki YAMATO
  • Patent number: 9950094
    Abstract: Provided are layered cell sheets, comprising a plurality of layered cell sheets containing myoblasts, in which each cell sheet comprises cell population containing myoblasts with controlled orientations. Preferably provided are the layered cell sheets comprising a region in which the orientations of the cell population containing the myoblasts in each cell sheet are identical to each other.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: April 24, 2018
    Assignee: Tokyo Women's Medical University
    Inventors: Hironobu Takahashi, Tatsuya Shimizu, Teruo Okano
  • Patent number: 9919139
    Abstract: With the present invention the sheet shaped therapeutic substance can be accurately and easily affixed to the inside of the human body. As shown in FIG. 6A, the sheet shaped substance can be mounted on the head with wrinkles being formed. When this takes place, the sheet shaped substance is held in contact with the outer periphery of the head. Then, by making the pressure of the fluid inside the vent apertures positive, the sheet shaped substance can be blown off. The surface of the head is closely parallel to an inner surface of the esophagus wall for the sheet shaped substance to be affixed. Therefore, this particularly makes it possible to perform such applying step (FIG. 6B) in a more reliable fashion.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: March 20, 2018
    Assignee: Tokyo Women's Medical University
    Inventors: Nobuyuki Tanaka, Nobuo Kanai, Masayuki Yamato, Teruo Okano
  • Patent number: 9889228
    Abstract: The problem to be solved by the present invention is to provide a cultured cell sheet having a superior tissue adhesiveness and an excellent flexibility. The problems can be solved by producing the cultured cell sheet in which cells are cultured in the presence of a surfactant protein or a cross-linking inhibitor on a surface of a cell culture support that is coated with a temperature responsive polymer having an upper or lower critical solution temperature ranging from 0° C. to 80° C. in water, including steps of: adjusting the temperature of the culture medium to a temperature below the lower critical solution temperature or above the upper critical solution temperature; and detaching the cultured cell sheet.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: February 13, 2018
    Assignee: CELLSEED INC.
    Inventors: Masato Kanzaki, Masayuki Yamato, Tinatsu Kohno, Hidekazu Sekine, Akihiko Kikuchi, Teruo Okano, Takamasa Onuki
  • Patent number: 9783773
    Abstract: A cell culture apparatus includes: an isolator in which a sterile space accommodating a cell incubator filled with a culture solution containing cells to be cultured is disposed; a sampling unit configured to sample the culture solution in the cell incubator; a delivery flow path through which an inside of the sterile space and an outside of the sterile space communicate with each other, the delivery flow path configured to limit a flow in the delivery flow path to a direction that is directed from the inside of the sterile space toward the outside of the sterile space; and a culture solution delivering section configured to deliver the sampled culture solution to the outside of the sterile space via the delivery flow path.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: October 10, 2017
    Assignees: NIHON KOHDEN CORPORATION, TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Mitsuhiro Oura, Teruo Okano, Tatsuya Shimizu, Hirotsugu Kubo, Sunao Takeda
  • Publication number: 20170216362
    Abstract: The present invention provides a method of inhibiting progression of or preventing renal disorder, the method comprising applying a cell sheet composition for inhibiting progression of or preventing renal disorder to at least one part of the surface of a kidney, wherein the part of the surface is uncovered by a fibrous capsule of the kidney. The present invention also provides a cell sheet composition for inhibiting progression of or preventing renal disorder, the cell sheet composition comprising a cell that has a function of producing a hepatocyte growth factor (HGF). The present invention also provides a method of producing a cell sheet composition for inhibiting progression of or preventing renal disorder.
    Type: Application
    Filed: January 25, 2017
    Publication date: August 3, 2017
    Applicant: TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Masatoshi Oka, Sachiko Sekiya, Tatsuya Shimizu, Kosaku Nitta, Teruo Okano
  • Patent number: 9708578
    Abstract: A measuring unit which is to be attached to a cell culture container configured to accommodate cells to be cultured and a culture solution, includes: a measurer which is configured to measure information related to the cells and the culture solution, in a non-contact manner; and a sensor which is configured to detect at least one of a position, a posture, an impact, an orientation, and vibration.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 18, 2017
    Assignees: NIHON KOHDEN CORPORATION, TOKYO WOMEN'S MEDICAL UNIVERSITY
    Inventors: Mitsuhiro Oura, Hirotsugu Kubo, Katsuyoshi Suzuki, Katsuhide Tone, Teruo Okano, Tatsuya Shimizu
  • Publication number: 20170157292
    Abstract: A complex of implant and cultured periodontal ligament cell sheet, that can be satisfactorily stabilized into the bone through periodontal ligament tissue, is provided. A fixture of the inserted implant is coated with calcium phosphate and the cultured periodontal ligament cell sheet is brought into intimate contact with the implant.
    Type: Application
    Filed: June 24, 2015
    Publication date: June 8, 2017
    Inventors: Kaoru WASHIO, Isao ISHIKAWA, Teruo OKANO
  • Patent number: 9643173
    Abstract: Provided is a temperature responsive adsorbent prepared by immobilizing a copolymer containing at least N-isopropylacrylamide to a base material surface. The copolymer has at least a strong cation exchange group. In addition, the copolymer contains the strong cation exchange group in an amount of 0.01 to 5 mol % relative to N-isopropylacrylamide in terms of monomer.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: May 9, 2017
    Assignee: ASAHI KASEI MEDICAL CO., LTD.
    Inventors: Ichiro Koguma, Hiroki Shigematsu, Kazuo Okuyama, Teruo Okano, Yoshikatsu Akiyama, Kenichi Nagase
  • Patent number: 9643174
    Abstract: Provided is a temperature responsive adsorbent prepared by immobilizing a copolymer containing at least N-isopropylacrylamide to a base material surface. The copolymer has at least a strong cation exchange group. In addition, the copolymer contains the strong cation exchange group in an amount of 0.01 to 5 mol % relative to N-isopropylacrylamide in terms of monomer.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: May 9, 2017
    Assignee: ASAHI KASEI MEDICAL CO., LTD.
    Inventors: Ichiro Koguma, Hiroki Shigematsu, Kazuo Okuyama, Teruo Okano, Yoshikatsu Akiyama, Kenichi Nagase
  • Patent number: 9623052
    Abstract: The present invention provides a method for producing a myocardial sheet using a group of cells derived from embryonic stem cells. This method is characterized by mixing Flk/KDR positive cells, cardiomyocytes, endothelial cells, and mural cells, all derived from embryonic stem cells, and culturing the mixed cells. Furthermore, the myocardial sheet can be used as a therapeutic agent for heart diseases since VEGF is released from the sheet.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: April 18, 2017
    Assignees: Tokyo Women's Medical University, Kyoto University
    Inventors: Teruo Okano, Tatsuya Shimizu, Jun Yamashita, Hidetoshi Masumoto