Patents by Inventor Teruo Yamamori
Teruo Yamamori has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8124625Abstract: Compounds having an activity to enhance the expression of apoAI are provided. Compounds of formula (I): in which Ar1 and Ar2 are independently a phenyl, naphthyl, or monocyclic or bicyclic aromatic heterocyclic group, which may be optionally substituted; —X— is —N?CZ2—, —CY2?CZ2—, —CY2Y3—CHZ2—, —S—, —O—, or the like; Y1, Y2, Y3, Z1 and Z2 are independently a hydrogen, a halogen, a lower alkyl, a phenyl, or the like; Z1 and Z2 may be independently a linker group that may combine with Ar2 and Ar1 to form a condensed ring; m is 0 or 1, and n is 0 to 2; a prodrug thereof, a pharmaceutically acceptable salt or solvate thereof; are disclosed.Type: GrantFiled: September 14, 2001Date of Patent: February 28, 2012Assignee: Shionogi & Co., Ltd.Inventors: Teruo Yamamori, Kiyoshi Nagata, Natsuki Ishizuka, Kunio Hayashi
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Patent number: 8106051Abstract: Compounds having an activity to enhance the expression of apoAI are provided, which are used as medicaments. Compounds of formula (I): in which ring A and Ar1 are independently a monocyclic or bicyclic aromatic carbocyclic group or aromatic heterocyclic group, each of which may be optionally substituted, or the like; R is a hydrogen or the like; Z is oxygen or the like; Y1 and Y2 are a hydrogen, a lower alkyl, or the like; n is an integer of 0 to 2; the broken line is the presence or absence of a bond; and the wavy line represents a cis- or trans-geometrical isomerism with respect to the double bond; are disclosed.Type: GrantFiled: April 18, 2008Date of Patent: January 31, 2012Assignee: Shionogi & Co., Ltd.Inventors: Teruo Yamamori, Kiyoshi Nagata, Natsuki Ishizuka, Katsunori Sakai
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Patent number: 8053445Abstract: Compounds having an activity to enhance the expression of apoAI are provided. Compounds of formula (I): in which Ar1 and Ar2 are independently a phenyl, naphthyl, or monocyclic or bicyclic aromatic heterocyclic group, which may be optionally substituted; —X— is —N?CZ2—, —CY2?CZ2—, —CY2Y3—CHZ2—, —S—, —O—, or the like; Y1, Y2, Y3, Z1 and Z2 are independently a hydrogen, a halogen, a lower alkyl, a phenyl, or the like; Z1 and Z2 may be independently a linker group that may combine with Ar2 and Ar1 to form a condensed ring; m is 0 or 1, and n is 0 to 2; a prodrug thereof, a pharmaceutically acceptable salt or solvate thereof; are disclosed.Type: GrantFiled: September 9, 2008Date of Patent: November 8, 2011Assignee: Shionogi & Co., Ltd.Inventors: Teruo Yamamori, Kiyoshi Nagata, Kunio Hayashi
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Publication number: 20090036457Abstract: Compounds having an activity to enhance the expression of apoAI are provided. Compounds of formula (I): in which Ar1 and Ar2 are independently a phenyl, naphthyl, or monocyclic or bicyclic aromatic heterocyclic group, which may be optionally substituted; —X— is —N?CZ2-, —CY2?CZ2-, —CY2Y3—CHZ2-, —S—, —O—, or the like; Y1, Y2, Y3, Z1 and Z2 are independently a hydrogen, a halogen, a lower alkyl, a phenyl, or the like; Z1 and Z2 may be independently a linker group that may combine with Ar2 and Ar1 to form a condensed ring; m is 0 or 1, and n is 0 to 2; a prodrug thereof, a pharmaceutically acceptable salt or solvate thereof; are disclosed.Type: ApplicationFiled: September 9, 2008Publication date: February 5, 2009Inventors: Teruo Yamamori, Kiyoshi Nagata, Natsuki Ishizuka, Kunio Hayashi
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Patent number: 7429593Abstract: Compounds having an activity to enhance the expression of apoAI are provided, which are used as medicaments. Compounds of formula (I): in which ring A and Ar1 are independently a monocyclic or bicyclic aromatic carbocyclic group or aromatic heterocyclic group, each of which may be optionally substituted, or the like; R is a hydrogen or the like; Z is oxygen or the like; Y1 and Y2 are a hydrogen, a lower alkyl, or the like; n is an integer of 0 to 2; the broken line is the presence or absence of a bond; and the wavy line represents a cis- or trans-geometrical isomerism with respect to the double bond; are disclosed.Type: GrantFiled: September 14, 2001Date of Patent: September 30, 2008Assignee: Shionogi & Co., Ltd.Inventors: Teruo Yamamori, Kiyoshi Nagata, Natsuki Ishizuka, Katsunori Sakai
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Publication number: 20080221112Abstract: Compounds having an activity to enhance the expression of apoAI are provided, which are used as medicaments. Compounds of formula (I): in which ring A and Ar1 are independently a monocyclic or bicyclic aromatic carbocyclic group or aromatic heterocyclic group, each of which may be optionally substituted, or the like; R is a hydrogen or the like; Z is oxygen or the like; Y1 and Y2 are a hydrogen, a lower alkyl, or the like; n is an integer of 0 to 2; the broken line is the presence or absence of a bond; and the wavy line represents a cis- or trans-geometrical isomerism with respect to the double bond; are disclosed.Type: ApplicationFiled: April 18, 2008Publication date: September 11, 2008Inventors: Teruo Yamamori, Kiyoshi Nagata, Natsuki Ishizuka, Katsunori Sakai
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Publication number: 20040248950Abstract: Pharmaceutical compositions for enhancing the expression of apoAI are provided.Type: ApplicationFiled: March 18, 2004Publication date: December 9, 2004Inventors: Natsuki Ishizuka, Kiyoshi Nagata, Teruo Yamamori, Katsunori Sakai
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Publication number: 20040242615Abstract: Compounds having an activity to enhance the expression of apoAI are provided.Type: ApplicationFiled: April 19, 2004Publication date: December 2, 2004Inventors: Teruo Yamamori, Kiyoshi Nagata, Natsuki Ishizuka, Kunio Hayashi
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Publication number: 20040235888Abstract: Compounds having an activity to enhance the expression of apoAI are provided, which are used as medicaments.Type: ApplicationFiled: April 21, 2004Publication date: November 25, 2004Inventors: Teruo Yamamori, Kiyoshi Nagata, Natsuki Ishizuka, Katsunori Sakai
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Patent number: 5473066Abstract: Process for stereoselectivity preparing a cis-form of 5-(aminoalkylamino)-1,5-benzothiazepine derivative represented by formula (VI): ##STR1## is provided, said process comprising carrying out a stereoselective addition reaction of an o-(aminoalkylamino) thiophenyl derivative with a trans-substituted glycidic ester at an elevated temperature in a nonpolar solvent in the presence of a divalent or trivalent iron ion to prepare a threo-form intermediate, hydrolyzing the ester group of said intermediate, acetylating the hydroxyl group of said hydrolyzed compound, and subjecting said acetylated compound to a ring closure reaction to obtain the objective compound (VI).Type: GrantFiled: January 19, 1994Date of Patent: December 5, 1995Assignee: Shionogi & Co., Ltd.Inventors: Teruo Yamamori, Hiroshi Harada, Eiichi Oosugi, Katsunori Sakai
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Patent number: 5462936Abstract: A compound of the formula: ##STR1## wherein X is .dbd.N--A--R.sup.1 or .dbd.C(R.sup.1)R.sup.2 ; A is a single bond, polymethylerie or --CO--; R.sup.1 and R.sup.2 are each hydrogen, C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, unsubstituted or substituted phenyl, optionally substituted benzhydryl, or optionally substituted 5 to 6 membered heterocyclic group; Y is hydrogen, halogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.1-6 alkoxy, optionally substituted phenoxy, optionally substituted benzyloxy, or optionally substituted benzyl; Z is hydrogen or acyl; n is an integer of from 2 to 6, and pharmaceutically acceptable salt thereof. A pharmaceutical composition containing the compound, which is useful for treating hypertension and cardiac diseases, is also provided.Type: GrantFiled: August 22, 1994Date of Patent: October 31, 1995Assignee: Shionogi & Co., Ltd.Inventors: Teruo Yamamori, Hiroshi Harada, Katsunori Sakai, Kazumi Iwaki, Kazuki Matsunaga
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Patent number: 5378698Abstract: A compound of the formula: ##STR1## wherein X is .dbd.N--A--R.sup.1 or .dbd.C(R.sup.1)R.sup.2 ; A is a single bond, polymethylene or --CO--; R.sup.1 and R.sup.2 are each hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl, unsubstituted or substituted phenyl, optionally substituted benzhydryl, or optionally substituted 5 to 6 membered heterocyclic group; Y is hydrogen, halogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.1 -C.sub.6 alkoxy, optionally substituted phenoxy, optionally substituted benzyloxy, or optionally substituted benzyl; Z is hydrogen or acyl; n is an integer of from 2 to 6, and pharmaceutically acceptable salt thereof. A pharmaceutical composition containing the compound, which is useful for treating hypertension and cardiac diseases, is also provided.Type: GrantFiled: October 14, 1992Date of Patent: January 3, 1995Assignee: Shionogi & Co., Ltd.Inventors: Teruo Yamamori, Hiroshi Harada, Katsunori Sakai, Kazumi Iwaki, Kazuki Matsunaga
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Patent number: 4873334Abstract: Novel Ca-blockers, 4,7-dihydropyrazolo[3,4-b]pyridine derivatives having potent antihypertensive and coronary vasodilating actions and useful in treatment for diseases in circulatory system, but without systole inhibitory action.Type: GrantFiled: September 22, 1987Date of Patent: October 10, 1989Assignee: Shionogi & Co., Ltd.Inventors: Ikuo Adachi, Teruo Yamamori, Motohiko Ueda, Hatsuo Sato
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1,6-Dialkyl-3-su bstituted-4-nitrophenyl-4,7-dihydropyrazolo[3,4-b]pyridine-5-carboxylic acid esters
Patent number: 4562256Abstract: 1,6-Dialkyl-3-substituted-4-nitrophenyl-4,7-dihydropyrazolo[3,4-b]pyridine- 5-carboxylic acid esters as Ca blocker having potent antihypertensive and coronary vasodilating actions and useful in treatment of diseases in circulatory system such as angina pectoris, hypertension, cerebrovascular dysfunction, arrhythmia, etc. with no systole inhibitory action, prepared from nitrobenzylideneacetoacetic acid esters on reaction with 3-substituted-5-amino-1-alkylpyrazoles.Type: GrantFiled: August 17, 1984Date of Patent: December 31, 1985Assignee: Shionogi & Co., Ltd.Inventors: Ikuo Adachi, Teruo Yamamori, Motohiko Ueda, Masami Doteuchi -
Patent number: 4190728Abstract: Lower alkyl 2-chloro-2-hydroxyiminoacetates are produced by (A) reacting chloral with a lower alkanol and a hydroxylamine salt in the presence of a Lewis acid or a metal oxide which is convertible into said Lewis acid during the course of the reaction to give a lower alkyl 2-hydroxyiminoacetate and then chlorinating the resulting product or (B) reacting chloral oxime with a lower alkanol in the presence of a base to give a lower alkyl 2-hydroxyiminoacetate and finally chlorinating the thus formed product.Type: GrantFiled: April 11, 1978Date of Patent: February 26, 1980Assignee: Shionogi & Co., Ltd.Inventors: Ikuo Adachi, Teruo Yamamori, Yoshiharu Hiramatsu