Patents by Inventor Teruyoshi Koga
Teruyoshi Koga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9518004Abstract: A reduced coenzyme Q10 derivative represented by formula (1), wherein R1 and R2 are each independently H or an alkoxycarbonyl group represented by formula (2), and at least one of them is an alkoxycarbonyl group represented by the formula (2); in the formula (2), R3 is an optionally substituted linear, branched, or cyclic alkyl group having 1 to 20 carbon atoms, an optionally substituted aryl group having 6 to 20 carbon atoms, or an optionally substituted heteroaryl group having 4 to 20 carbon atoms, and when R3 is a group substituted with polyethylene glycol, the molecular weight of the polyethylene glycol is not more than 300.Type: GrantFiled: December 2, 2013Date of Patent: December 13, 2016Assignee: KANEKA CORPORATIONInventors: Teruyoshi Koga, Yoshihisa Okamoto, Takao Yamaguchi
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Publication number: 20150307440Abstract: A reduced coenzyme Q10 derivative represented by formula (1), wherein R1 and R2 are each independently H or an alkoxycarbonyl group represented by formula (2), and at least one of them is an alkoxycarbonyl group represented by the formula (2); in the formula (2), R3 is an optionally substituted linear, branched, or cyclic alkyl group having 1 to 20 carbon atoms, an optionally substituted aryl group having 6 to 20 carbon atoms, or an optionally substituted heteroaryl group having 4 to 20 carbon atoms, and when R3 is a group substituted with polyethylene glycol, the molecular weight of the polyethylene glycol is not more than 300.Type: ApplicationFiled: December 2, 2013Publication date: October 29, 2015Applicant: KANEKA CORPORATIONInventors: Teruyoshi KOGA, Yoshihisa OKAMOTO, Takao YAMAGUCHI
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Patent number: 8232389Abstract: The present invention relates to a method for crystallization of (2R)-2-{(3S,4S)-3-[(1R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-oxoazetidin-4-yl}propionic acid, and is characterized in that crystallization is carried out by mixing a solution containing the compound with a substituted aromatic hydrocarbon solvent and/or a halogenated hydrocarbon solvent. The method can provide a crystal of the compound with a high purity and a high yield while the content of 2S isomer is kept at a low level.Type: GrantFiled: June 13, 2007Date of Patent: July 31, 2012Assignee: Kaneka CorporationInventors: Keita Nishino, Teruyoshi Koga, Masafumi Fukae, Yasuyoshi Ueda
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Patent number: 8093378Abstract: An improved crystallization method for an azetidinone compound represented by the formula 1: , which is extremely useful as a common intermediate for the synthesis of 1?-methylcarbapenem compounds. The present method provides crystals having higher quality and stability than conventional crystals and excellent filterability at the time of recovery; and an azetidinone compound having a low content of impurity, and which has a controlled particle size distribution of crystals and improved handleability and stability. The crystallization is carried out by adding a hydrocarbon solvent to a solution in which an azetidinone compound extremely useful as a common intermediate for the synthesis of 1?-methylcarbapenem compounds is dissolved in the presence of a seed crystal in an amount of 200% by weight or less based on the weight of the azetidinone compound.Type: GrantFiled: April 18, 2007Date of Patent: January 10, 2012Assignee: Kaneka CorporationInventors: Keita Nishino, Teruyoshi Koga, Masafumi Fukae, Yasuyoshi Ueda
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Publication number: 20100298556Abstract: The present invention relates to a method for crystallization of (2R)-2-{(3S, 4S)-3-[(1R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-oxoazetidin-4-yl}propionic acid, and is characterized in that crystallization is carried out by mixing a solution containing the compound with a substituted aromatic hydrocarbon solvent and/or a halogenated hydrocarbon solvent. The method can provide a crystal of the compound with a high purity and a high yield while the content of 2S isomer is kept at a low level.Type: ApplicationFiled: June 13, 2007Publication date: November 25, 2010Applicant: KANEKA CORPORATIONInventors: Keita Nishino, Teruyoshi Koga, Masafumi Fukae, Yasuyoshi Ueda
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Publication number: 20100240886Abstract: The present invention has its object to provide an easy process for producing (4R,5S,6S)-3-[[(3S,5S)-5-(dimethylaminocarbonyl)-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, excellent in antimicrobial activity. The present invention relates to a process for continuously producing (4R,5S,6S)-3-[[(3S,5S)-5-(dimethylaminocarbonyl)-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid without isolating/purifying the reaction intermediate.Type: ApplicationFiled: March 27, 2007Publication date: September 23, 2010Applicant: Kaneka CorporationInventors: Keita Nishino, Teruyoshi Koga
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Patent number: 7538212Abstract: The present invention provides a novel intermediate represented by formula (1), (3), or (4) for efficiently producing a 1?-methylcarbapenem compound for oral administration, and a process for producing the intermediate. That is, the present invention provides a process for producing a novel ?-lactam compound represented by formula (4), the process including allowing a ?-lactam compound represented by formula (5) as a starting material to react with a compound represented by formula (6) in the presence of a base to obtain a novel ?-lactam compound represented by formula (1), protecting the hydroxyl group, subsequently performing cyclization in the presence of a strong base, allowing the cyclized compound to react with diphenylphosphoryl chloride to obtain a novel ?-lactam compound represented by formula (3), and eliminating the protecting group therefrom.Type: GrantFiled: November 13, 2003Date of Patent: May 26, 2009Assignee: Kaneka CorporationInventors: Keita Nishino, Teruyoshi Koga
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Publication number: 20090118496Abstract: The present invention relates to an azetidinone compound extremely useful as a common intermediate for the synthesis of 1?-methylcarbapenem compounds. The present invention provides a crystallization method to obtain a crystal which has a higher quality and a higher stability than a conventional crystal and is excellent in filterability at the time of recovering crystal; an azetidinone compound having a low content of impurity; and an azetidinone compound which has a controlled particle size distribution of crystals and improved handleability and stability. The crystallization is carried out by adding a hydrocarbon solvent to a solution in which an azetidinone compound extremely useful as a common intermediate for the synthesis of 1?-methylcarbapenem compounds is dissolved in the presence of a seed crystal in an amount of 200% by weight or less based on the weight of the azetidinone compound.Type: ApplicationFiled: April 18, 2007Publication date: May 7, 2009Applicant: KANEKA CORPORATIONInventors: Keita Nishino, Teruyoshi Koga, Masafumi Fukae, Yasuyoshi Ueda
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Patent number: 7524952Abstract: The present invention provides a process for efficiently producing a 1?-methylcarbapenem compound for oral administration. The process, which is for producing a 1?-methylcarbapenem compound represented by general formula (2), is characterized by reacting a ?-lactam compound represented by general formula (1) as a starting material with a thiol compound (R3—SH) in the presence of a base and optionally eliminating the protective group R1. In the formulae (1) and (2), R1 denotes a hydrogen atom, a trimethylsilyl group or a triethylsilyl group; R2 denotes an alkyl group having 1 to 10 carbon atoms or a cycloalkyl group having 3 to 10 carbon atoms; R3 denotes an organic group; and R4 denotes hydrogen, a trimethylsilyl group or a triethylsilyl group.Type: GrantFiled: November 13, 2003Date of Patent: April 28, 2009Assignee: Kaneka CorporationInventors: Keita Nishino, Teruyoshi Koga
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Publication number: 20060252929Abstract: The present invention provides a novel intermediate for efficiently producing a 1?-methylcarbapenem compound for oral administration, and a process for producing the intermediate. That is, the present invention provides a process for producing a novel ?-lactam compound represented by general formula (4), the process including allowing a lactam compound represented by general formula (5) as a starting material to react with a compound represented by general formula (6) in the presence of a base to obtain a novel ?-lactam compound represented by general formula (1), protecting the hydroxyl group, subsequently performing cyclization in the presence of a strong base, allowing the cyclized compound to react with diphenylphosphoryl chloride to obtain a novel ?-lactam compound represented by general formula (3), and eliminating the protecting group therefrom.Type: ApplicationFiled: November 13, 2003Publication date: November 9, 2006Inventors: Keita Nishino, Teruyoshi Koga
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Publication number: 20060009442Abstract: The present invention provides a process for efficiently producing a 1?-methylcarbapenem compound for oral administration. The process, which is for producing a 1?-methylcarbapenem compound represented by general formula (2), is characterized by reacting a ?-lactam compound represented by general formula (1) as a starting material with a thiol compound (R3—SH) in the presence of a base and optionally eliminating the protective group R1. In the formulae (1) and (2), R1 denotes a hydrogen atom, a trimethylsilyl group or a triethylsilyl group; R2 denotes an alkyl group having 1 to 10 carbon atoms or a cycloalkyl group having 3 to 10 carbon atoms; R3 denotes an organic group; and R4 denotes hydrogen, a trimethylsilyl group or a triethylsilyl group.Type: ApplicationFiled: November 13, 2003Publication date: January 12, 2006Inventors: Keita Nishino, Teruyoshi Koga
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Patent number: 5214197Abstract: A novel 2,4-dihydroxyadipic acid derivative of the formula: ##STR1## wherein R.sup.1 and R.sup.4 are the same or different and each a hydrogen atom, an alkyl group, an aralkyl group, an aryl group or a silyl group, and R.sup.2 and R.sup.3 are the same or different and each a hydrogen atom or a protective group of a hydroxy group or together form a ring, which is useful as a common intermediate in the synthesis of HMG-CoA reductase inhibitor.Type: GrantFiled: July 2, 1991Date of Patent: May 25, 1993Assignee: Kanegafuchi Chemical Industry Co., Ltd.Inventors: Shigeo Hayashi, Noboru Ueyama, Kenji Inoue, Teruyoshi Koga, Satomi Takahashi
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Patent number: 5214199Abstract: A malonic monoester is prepared in a good yield by a single step reaction by reacting malonic acid with an alcohol in the presence of a base and an activator of malonic acid selected from the group consisting of an acyl halide or halocarbonate and an acid anhydride or dicarbonate.Type: GrantFiled: August 30, 1991Date of Patent: May 25, 1993Assignee: Kanegafuchi Chemical Industries Co., Ltd.Inventors: Teruyoshi Koga, Noboru Ueyama, Kenji Inoue, Satomi Takahashi