Patents by Inventor Teruyuki Nagamune

Teruyuki Nagamune has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150375017
    Abstract: Treatment is provided at an ideal timing. Provided is an ultrasonic treatment apparatus including: a therapeutic-ultrasound-wave radiating portion that radiates therapeutic ultrasound waves for causing an ultrasonic treatment material having a tendency to accumulate in an affected area to exert a therapeutic effect; an accumulation determining portion that determines whether or not the ultrasonic treatment material has accumulated in the affected area; and a determination-result presenting portion that presents a determination result obtained by the accumulation determining portion.
    Type: Application
    Filed: July 1, 2015
    Publication date: December 31, 2015
    Applicants: THE UNIVERSITY OF TOKYO, OLYMPUS CORPORATION
    Inventors: Miyuki MURAKAMI, Satoshi YAMAGUCHI, Teruyuki NAGAMUNE, Kosuke MINAMIHATA
  • Publication number: 20150328343
    Abstract: Provided is a contrast medium comprising at least one molecular probe and at least one optical probe on a surface of a substrate having an ultrasound imaging function. More specifically, a contrast medium having sensitivity to not only ultrasound but also light excellent in real-time imaging and resolution and having a size sufficient to travel into tissues through blood vessel can be provided by labelling an ultrasound imageable substrate with a molecular probe and an optical probe.
    Type: Application
    Filed: July 29, 2015
    Publication date: November 19, 2015
    Applicants: THE UNIVERSITY OF TOKYO, OLYMPUS CORPORATION
    Inventors: Miyuki Murakami, Satoshi Yamaguchi, Teruyuki Nagamune, Mariko Iijima, Yoshikazu Shibasaki
  • Patent number: 7595202
    Abstract: The present invention provides a method for controlling the spatial arrangement of an energy donor and an energy acceptor in a reaction complex in order to carry out the measurement with good precision and high sensitivity, and a measurement system using the method. Two types of material having affinity for the subject material to be measured are respectively labeled with a combination of reporters that give rise to energy transfer; those that have been thus obtained by labeling these materials are each further labeled with materials that have weak affinity for each other to give reagents, which are then mixed with a sample to give the reaction complex. Each of the materials is brought into spatial proximity by binding based on the affinity among the materials having weak affinity for each other in the reaction complex, and since that condition is stably maintained, a more efficient energy transfer occurs.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: September 29, 2009
    Assignees: Eiken Nagaku Kabushiki Kaisha
    Inventors: Teruyuki Nagamune, Hiroshi Ueda, Yoshiyuki Ohiro, Norio Shibata
  • Patent number: 7501280
    Abstract: In an inexpensive and convenient method for immobilizing a suspension cell, a phospholipid vesicle or the like regardless of the type of cell, on the surface of a solid phase, a cell is immobilized by causing the cell to contact a support having a hydrophobic chain and a hydrophilic chain.
    Type: Grant
    Filed: February 28, 2003
    Date of Patent: March 10, 2009
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventors: Teruyuki Nagamune, Jun Miyake, Masato Miyake, Koichi Kato
  • Publication number: 20070287147
    Abstract: This invention provides a method to monitor a microorganism that causes infectious disease of a laboratory animal by using a micro flow channel chip immobilized with a molecular to be tested such as an antigen or an antibody of the microorganism that causes infectious disease, the method comprises flowing serum or body fluid taken from the laboratory animal through the minute flow channel of the micro flow channel chip and detecting the antigen antibody reaction on the chip. The method of this invention enabled medical inspection of an infectious disease of a laboratory animal and microorganism monitoring of a laboratory animal, by using minute amount of animal serum or body fluid in a closed system rapidly and sensitively.
    Type: Application
    Filed: March 2, 2005
    Publication date: December 13, 2007
    Applicant: NAGAMUNE, TERUYUKI
    Inventors: Teruyuki Nagamune, Akihiko Tajima, Yutaka Yamagata, Hiroyoshi Aoki
  • Patent number: 7198945
    Abstract: A cell in which a reaction product of a substance to be modified and an amphipathic compound is non-covalently bound to a cell membrane, wherein said compound has the following features: (1) having one or more aliphatic hydrocarbon groups at one end; (2) having one or more portions containing a hydrophilic group in a molecule; and (3) having one or more reactive functional groups which are capable of covalently binding with the substance to be modified at an end different from the end in the above (1).
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: April 3, 2007
    Assignees: Teruyuki Nagamune, NOF Corporation
    Inventors: Teruyuki Nagamune, Chika Itoh, Tohru Yasukohchi, Syunsuke Ohhashi, Kazuhiro Kubo
  • Publication number: 20060252028
    Abstract: A novel method for determining interaction between VH fragment and VL fragment of the variable region of an antibody is provided by the present invention. The method according to this invention can be widely used for detection of protein interactions. If a phagemid vector containing an amber codon is used for transformation of an amber suppressor strain of E. coli according to the method of the invention to produce phages, both of the VH fragment and the VL fragment will be displayed on the phage particles. In contrast, if the same vector is used to transformation of an amber non-suppressing strain of E. coli to produce phages, for the presence of the amber codon, only the VH fragment will be displayed on the phage particles, while the VL fragment will be secreted into the culture medium by the E. coli. Thus, display switch occurs.
    Type: Application
    Filed: August 15, 2003
    Publication date: November 9, 2006
    Inventors: Hiroshi Ueda, Teruyuki Nagamune
  • Publication number: 20050208644
    Abstract: Aspects of the invention can provide a method of immobilizing a chemical compound having the affinity for the cell membrane on the solid-phase surface in a desired pattern. The method of immobilizing a cell in a desired pattern on a solid-phase surface by use of a first chemical compound having an affinity for the cell and can include a step of immobilizing a second chemical compound, which is more easily immobilized on the solid-phase surface than the first chemical compound dose and has a molecular binding site that can bind to the first chemical compound, on the solid-phase surface according to the pattern.
    Type: Application
    Filed: March 22, 2005
    Publication date: September 22, 2005
    Applicant: SEIKO EPSON CORPORATION
    Inventors: Hiroshi Takiguchi, Hitoshi Fukushima, Takashi Masuda, Teruyuki Nagamune, Masashige Shinkai, Kengo Yamawaki
  • Publication number: 20050106721
    Abstract: In an inexpensive and convenient method for immobilizing a suspension cell, a phospholipid vesicle or the like regardless of the type of cell, on the surface of a solid phase, a cell is immobilized by causing the cell to contact a support having a hydrophobic chain and a hydrophilic chain.
    Type: Application
    Filed: February 28, 2003
    Publication date: May 19, 2005
    Inventors: Teruyuki Nagamune, Jun Miyake, Masato Miyake, Koichi Kato
  • Publication number: 20040110245
    Abstract: The present invention provides, in the use of the energy transfer phenomenon in a detection system for the measurement of the concentration of a material, a method for controlling the spatial arrangement of an energy donor and an energy acceptor in a reaction complex in order to carry out the measurement with good precision and high sensitivity, and a measurement system using the method.
    Type: Application
    Filed: October 20, 2003
    Publication date: June 10, 2004
    Inventors: Teruyuki Nagamune, Hiroshi Ueda, Yoshiyuki Ohiro, Norio Shibata
  • Publication number: 20030114523
    Abstract: A cell in which a reaction product of a substance to be modified and an amphipathic compound is non-covalently bound to a cell membrane, wherein said compound has the following features:
    Type: Application
    Filed: August 5, 2002
    Publication date: June 19, 2003
    Applicant: NOF Corporation
    Inventors: Teruyuki Nagamune, Chika Itoh, Tohru Yasukohchi, Syunsuke Ohhashi, Kazuhiro Kubo
  • Publication number: 20030095962
    Abstract: This invention provides a system for controlling the phenotypic characteristics of cells. A pair of chimeric polypeptides is anchored in the plasma membrane, each of which has a variable region sequence and an effector sequence. The polypeptides are independent in the absence of antigen, but form a stable complex with each other when antigen is provided. This drives the effector sequences together in a manner that produces a receptor activation signal, leading to a phenotypic change. By titrating the amount of antigen present in the environment, the degree of phenotypic change can be regulated. Cells bearing chimeric polypeptides can be used to measure the concentration of antigen or select cells transfected with a therapeutic gene.
    Type: Application
    Filed: July 3, 2001
    Publication date: May 22, 2003
    Inventors: Hiroshi Ueda, Teruyuki Nagamune, Hajime Nishimura, Izumi Kumagai, Kouhei Tsumoto, Kazuo Todokoro, Paula A. Mahoney, Walt Mahoney
  • Patent number: 6482596
    Abstract: This invention provides a method for measuring an antigen concentration in a sample, which comprises: preparing VH-domain polypeptide and VL-domain polypeptide of an antibody specific to the antigen; labeling one of the polypeptides with a reporter molecule to form labeled polypeptides, and immobilizing the other polypeptide onto solid-phase to form immobilized polypeptides; contacting the antigen-containing sample and the labeled polypeptides with the solid-phase; and measuring the reporter molecule of the labeled polypeptides bound to the immobilized polypeptides. The present invention permits simpler and quicker sandwich ELISA for measurements of an antigen concentration in high sensitivity.
    Type: Grant
    Filed: May 18, 1999
    Date of Patent: November 19, 2002
    Assignee: Roche Diagnostics Corporation
    Inventors: Hiroshi Ueda, Teruyuki Nagamune, Hajime Nishimura, Izumi Kumagai, Kouhei Tsumoto, Walter C. Mahoney, Greg Winter, Paula A. Schueler
  • Patent number: 5981199
    Abstract: This invention provides a method for measuring an antigen concentration in a sample, which comprises: preparing VH-domain polypeptide and VL-domain polypeptide of an antibody specific to the antigen; labeling one of the polypeptides with a reporter molecule to form labeled polypeptides, and immobilizing the other polypeptides onto solid-phase to form immobilized polypeptides; contacting the antigen-containing sample and the labeled polypeptides with the solid-phase; and measuring the reporter molecule of the labeled polypeptides bound to the immobilized polypeptides. The present invention permits simpler and quicker sandwich ELISA for measurements of an antigen concentration in high sensitivity.
    Type: Grant
    Filed: June 14, 1996
    Date of Patent: November 9, 1999
    Assignee: Boehringer Mannheim Corporation
    Inventors: Hiroshi Ueda, Teruyuki Nagamune, Hajime Nishimura, Izumi Kumagai, Kouhei Tsumoto, Walter C. Mahoney, Greg Winter, Paula A. Schueler
  • Patent number: 5888805
    Abstract: A detecting apparatus is disclosed, that comprises plural measurement devices with respective sensors and a support for holding the measurement devices in such a manner that the individual sensors contact a culture broth, the turbidity, dissolved oxygen, dissolved carbon dioxide the temperature, pH, and so forth of the culture broth being obtained by the measurement devices.
    Type: Grant
    Filed: May 28, 1997
    Date of Patent: March 30, 1999
    Assignees: Rikagaku Kenkyusho, Komatsugawa Chemical Engineering Co., Ltd.
    Inventors: Isao Endo, Teruyuki Nagamune, Kozo Inoue, Kinichi Kawamura
  • Patent number: 5334497
    Abstract: A method of feeding substrates into a tubular bioreactor incorporating a reacting vessel and a separating membrane in which the reaction and separation or collection can be continuously and surely effected in the same vessel with high efficiency.
    Type: Grant
    Filed: November 4, 1991
    Date of Patent: August 2, 1994
    Inventors: Hideki Inaba, Isao Endo, Teruyuki Nagamune, Susumu Tachikawa
  • Patent number: 5185255
    Abstract: A cell culture method proliferates microorganisms, particularly fungi such as molds, actinomycetes, animal cells, plant cells and so on to produce useful substances such as antibiotics, enzymes, proteins, polysaccharides, physiological active substances, and animal and plant hormones. Porous material including medium and cells to be proliferated is moved, whereby air is supplied to the surface of the porous material.
    Type: Grant
    Filed: April 4, 1990
    Date of Patent: February 9, 1993
    Assignee: Rikagaku Kenkyusho
    Inventors: Isao Endo, Teruyuki Nagamune, Minoru Nishimura, Tetsuo Kobayashi
  • Patent number: 5043283
    Abstract: Cell culture apparatus comprises a fluidized bed culture tank body in which cell attached porous material is fluidized by air flow, and a pre-culture tank for supplying medium to the fluidized bed culture tank body according to the amount of the liquid medium which is taken out of the fluidized bed culture tank body. By the use of a drain valve which can be controlled to remove liquid medium and porous material or just liquid medium, the cell culture apparatus can continuously produce metabolite.
    Type: Grant
    Filed: November 24, 1987
    Date of Patent: August 27, 1991
    Assignees: Rikagaku Kenkyusho, Shinko-Pfaudler Company Ltd.
    Inventors: Isao Endo, Teruyuki Nagamune, Tetsuo Kobayashi
  • Patent number: 4725148
    Abstract: In a turbidimeter for measuring a turbidity of a test solution to be measured i.e. culture solution in a fermentation apparatus, a semiconductor laser diode and a semiconductor photodiode are integrally arranged in a detection portion of the turbidimeter in such a manner that a laser beam emitted from the semiconductor laser diode is made incident upon the semiconductor photodiode through the test solution. Moreover, a protection circuit for the semiconductor laser diode and the semiconductor photodiode is also arranged in the turbidimeter to cut off a current flowed therethrough when an environmental temperature becomes above a predetermined temperature. Therefore, the turbidimeter can be made small in size and light in weight, and the turbidity can be measured accurately over wide range.
    Type: Grant
    Filed: May 30, 1985
    Date of Patent: February 16, 1988
    Assignees: Komatsugawa Chemical Engineering Co., Ltd., Rikagaku Kenkyusho, Fuji Facom Corporation
    Inventors: Isao Endo, Teruyuki Nagamune, Ichiro Inoue, Kozo Inoue, Tadashi Nohira, Ikuzo Kagami, Tatsuya Iwakura
  • Patent number: 4561779
    Abstract: Disclosed is an improved turbidimeter or instrument for measuring the concentration of a suspension using diffuser means for converting incident light into diffused light before passing through a suspension. The use of diffused light improves the linearity of the optical density vs. concentration characteristics over a relatively wide range.
    Type: Grant
    Filed: January 7, 1983
    Date of Patent: December 31, 1985
    Assignee: Rikagaku Kenkyusho
    Inventors: Teruyuki Nagamune, Ichiro Inoue, Noburu Takematsu