Patents by Inventor Teruyuki Sakai
Teruyuki Sakai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090176993Abstract: A novel calcium receptor active compound having the formula is provided: Ar1—[CR1R2]p—X—[CR3R4]q—[CR5R6]—NR7—[CR8R9]—Ar2 wherein: Ar1 is selected from the group consisting of aryl, heteroaryl, bis(arylmethyl)amino, bis(heteroarylmethyl)amino and arylmethyl(heteroarylmethyl)amino; X is selected from the group consisting of oxygen, sulfur, sulfinyl, sulfonyl, carbonyl and amino; R1, R2, R3, R4, R5, R6, R7, R8 and R9 are, for example, hydrogen or alkyl; Ar2 is selected from the group consisting of aryl and heteroaryl; p is an integer of from 0 to 6, inclusive; and, q is an integer of from 0 to 14, inclusive.Type: ApplicationFiled: March 13, 2003Publication date: July 9, 2009Inventors: Teruyuki Sakai, Atsuya Takami, Rika Nagao
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Patent number: 7495104Abstract: An objective of the present invention is to provide novel compounds which have inhibitory activity against autophosphorylation of an FGF receptor family and, when orally or intraveneously administered, can suppress the growth of cancer cells. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X represents CH or N; Z represents O or S; Q represents NR10, CR11R2, carbonyl, O, S(?O)m, wherein m is 0 to 2, or urea; R1 to R3 each independently represent H, OH, halogen, nitro, amino, alkyl, alkoxy or the like in which the alkyl and alkoxy groups are optionally substituted; R4 represents H; R5 to R8 each independently represent H, halogen, alkyl, or alkoxy; and R9 represents an optionally substituted carbocyclic or heterocyclic group.Type: GrantFiled: October 17, 2002Date of Patent: February 24, 2009Assignee: Kirin Beer Kabushiki KaishaInventors: Atsushi Miwa, Tetsuya Yoshino, Tatsushi Osawa, Teruyuki Sakai, Toshiyuki Shimizu, Yasunari Fujiwara
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Patent number: 7211587Abstract: An object of the present invention is to provide compounds having potent antitumor activity. The compounds according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts or solvates thereof: wherein X and Z represent CH or N; Y represents O or S; R1, R2, and R3 represent H, alkoxy or the like; R4 represents H; R5, R6, R7, and R8 represent H, halogen, alkoxy or the like; R9 and R10 represent H, alkyl or the like; and R11 represents optionally substituted azolyl.Type: GrantFiled: June 7, 2004Date of Patent: May 1, 2007Assignee: Kirin Beer Kabushiki KaishaInventors: Kazuo Kubo, Teruyuki Sakai, Rika Nagao, Yasunari Fujiwara, Toshiyuki Isoe, Kazumasa Hasegawa
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Patent number: 7135466Abstract: There are provided compounds which can be used in the treatment of diseases mediated by the autophosphorylation of a PDGF receptor, specifically, compounds which can inhibit neointima formation hypertrophy. The compounds are those represented by formula (I) or pharmacologically acceptable salts or solvates thereof: wherein R1 and R2 represent hydrogen, alkyl or the like; R3, R4, R5 and R6 represent hydrogen, halogen, alkyl, alkoxy or the like; R11 and R12 represent hydrogen, alkyl, alkylcarbonyl or the like; and A represents any one of formulae (i) to (x), provided that compounds wherein R3, R4, R5 and R6 represent hydrogen and A represents group (v) wherein u is 0 (zero) and R19 represents phenyl optionally substituted by halogen, alkyl, or alkoxy are excluded.Type: GrantFiled: December 22, 2000Date of Patent: November 14, 2006Assignee: Kirin Beer Kabushiki KaishaInventors: Teruyuki Sakai, Terufumi Senga, Takayuki Furuta, Atushi Miwa
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Publication number: 20060211717Abstract: There are provided compounds which can be used in the treatment of diseases mediated by the autophosphorylation of a PDGF receptor, specifically, compounds which can inhibit neointima formation hypertrophy. The compounds are those represented by formula (I) or pharmacologically acceptable salts or solvates thereof: wherein R1 and R2 represent hydrogen, alkyl or the like; R3, R4, R5, and R6 represent hydrogen, halogen, alkyl, alkoxy or the like; R11 and R12 represent hydrogen, alkyl, alkylcarbonyl or the like; and A represents any one of formulae (i) to (x), provided that compounds wherein R3, R4, R5 and R6 represent hydrogen and A represents group (v) wherein u is 0 (zero) and R19 represents phenyl optionally substituted by halogen, alkyl, or alkoxy are excluded.Type: ApplicationFiled: May 12, 2006Publication date: September 21, 2006Applicant: KIRIN BEER KABUSHIKI KAISHAInventors: Teruyuki Sakai, Terufumi Senga, Takayuki Furuta, Atsushi Miwa
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Patent number: 6939895Abstract: A novel calcium receptor active compound having the formula is provided: Ar1—[CR1R2]p—X—[CR3R4]q—[CR5R6]—NR7—[CR8R9]—Ar2 wherein: Ar1 is selected from the group consisting of aryl, heteroaryl, bis(arylmethyl)amino, bis(heteroarylmethyl)amino and arylmethyl(heteroarylmethyl)amino; X is selected from the group consisting of oxygen, sulfur, sulfinyl, sulfonyl, carbonyl and amino; R1, R2, R3, R4, R5, R6, R7, R8 and R9 are, for example, hydrogen or alkyl; Ar2 is selected from the group consisting of aryl and heteroaryl; p is an integer of from 0 to 6, inclusive; and, q is an integer of from 0 to 14, inclusive.Type: GrantFiled: December 19, 2002Date of Patent: September 6, 2005Assignee: NPS Pharmaceuticals, Inc.Inventors: Teruyuki Sakai, Atsuya Takami, Rika Nagao
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Publication number: 20050049264Abstract: An objective of the present invention is to provide novel compounds which have inhibitory activity against autophosphorylation of an FGF receptor family and, when orally or intraveneously administered, can suppress the growth of cancer cells. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X represents CH or N; Z represents O or S; Q represents NR10, CR11R2, carbonyl, O, S(?O)m, wherein m is 0 to 2, or urea; R1 to R3 each independently represent H, OH, halogen, nitro, amino, alkyl, alkoxy or the like in which the alkyl and alkoxy groups are optionally substituted; R4 represents H; R5 to R8 each independently represent H, halogen, alkyl, or alkoxy; and R9 represents an optionally substituted carbocyclic or heterocyclic group.Type: ApplicationFiled: October 17, 2002Publication date: March 3, 2005Applicant: Kirin Beer Kabushiki KaishaInventors: Atsushi Miwa, Tetsuya Yoshino, Tatsushi Osawa, Teruyuki Sakai, Toshiyuki Shimizu, Yasunari Fujiwara
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Patent number: 6821987Abstract: An object of the present invention is to provide compounds having potent antitumor activity. The compounds according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts or solvates thereof: wherein X and Z represent CH or N; Y represents O or S; R1, R2, and R3 represent H, alkoxy or the like; R4 represents H; R5, R6, R7, and R8 represent H, halogen, alkoxy or the like; R9 and R10 represent H, alkyl or the like; and R11 represents optionally substituted azolyl.Type: GrantFiled: April 26, 2002Date of Patent: November 23, 2004Assignee: Kirin Beer Kabushiki KaishaInventors: Kazuo Kubo, Teruyuki Sakai, Rika Nagao, Yasunari Fujiwara, Toshiyuki Isoe, Kazumasa Hasegawa
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Publication number: 20040229876Abstract: An object of the present invention is to provide compounds having potent antitumor activity.Type: ApplicationFiled: June 7, 2004Publication date: November 18, 2004Applicant: KIRIN BEER KABUSHIKI KAISHAInventors: Kazuo Kubo, Teruyuki Sakai, Rika Nagao, Yasunari Fujiwara, Toshiyuki Isoe, Kazumasa Hasegawa
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Publication number: 20040132727Abstract: There are provided compounds which can be used in the treatment of diseases mediated by the autophosphorylation of a PDGF receptor, specifically, compounds which can inhibit neointima formation hypertrophy.Type: ApplicationFiled: October 25, 2002Publication date: July 8, 2004Inventors: Teruyuki Sakai, Terufumi Senga, Takayuki Furuta, Atsushi Miwa
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Patent number: 6750255Abstract: A novel calcium receptor active compound having the formula is provided: Ar1—[CR1R2]p—X—[CR3R4]q—[CR5R6]—NR7—[CR8R9]—Ar2 wherein: Ar1 is selected from the group consisting of aryl, heteroaryl, bis(arylmethyl)amino, bis(heteroarylmethyl)amino and arylmethyl(heteroarylmethyl)amino; X is selected from the group consisting of oxygen, sulfur, sulfinyl, sulfonyl, carbonyl and amino; R1, R2, R3, R4, R5, R6, R7, R8 and R9 are, for example, hydrogen or alkyl; Ar2 is selected from the group consisting of aryl and heteroaryl; p is an integer of from 0 to 6, inclusive; and, q is an integer of from 0 to 14, inclusive.Type: GrantFiled: January 17, 2002Date of Patent: June 15, 2004Assignees: NPS Pharmaceuticals, Inc., Kirin Beer KabushikiInventors: Teruyuki Sakai, Atsuya Takami, Rika Nagao
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Publication number: 20030176485Abstract: A novel calcium receptor active compound having the formula is provided:Type: ApplicationFiled: November 21, 2002Publication date: September 18, 2003Applicant: NPS Pharmaceuticals, Inc.Inventors: Teruyuki Sakai, Atsuya Takami, Rika Nagao
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Publication number: 20030144526Abstract: A novel calcium receptor active compound having the formula is provided:Type: ApplicationFiled: December 19, 2002Publication date: July 31, 2003Applicant: NPS Pharmaceuticals, Inc.Inventors: Teruyuki Sakai, Atsuya Takami, Rika Nagao
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Publication number: 20030087907Abstract: An object of the present invention is to provide compounds having potent antitumor activity.Type: ApplicationFiled: April 26, 2002Publication date: May 8, 2003Applicant: KIRIN BEER KABUSHIKI KAISHAInventors: Kazuo Kubo, Teruyuki Sakai, Rika Nagao, Yasunari Fujiwara, Toshiyuki Isoe, Kazumasa Hasegawa
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Patent number: 6500816Abstract: Effective treatment of tumors, especially carcinomas, can be achieved by administering to man a photochemotherapeutic agent containing as an active ingredient a compound showing maximum absorption in the wavelength region of 800 to 1,200 nm, and then applying light rays of a wavelength of 800 to 1,200 nm.Type: GrantFiled: March 12, 2001Date of Patent: December 31, 2002Assignee: Nippon Kayaku Kabushiki KaishaInventors: Hisao Ekimoto, Masao Onishi, Chieko Seno, Teruyuki Sakai
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Publication number: 20020107406Abstract: A novel calcium receptor active compound having the formula is provided:Type: ApplicationFiled: January 17, 2002Publication date: August 8, 2002Applicant: NPS Pharmaceuticals, Inc.Inventors: Teruyuki Sakai, Atsuya Takami, Rika Nagao
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Patent number: 6362231Abstract: A novel calcium receptor active compound having the formula is provided: Ar1—[CR1R2]P—X—[CR3R4]q—[CR5R6]—NR7—[CR8R9]—Ar2 wherein: Ar1 is selected from the group consisting of aryl, heteroaryl, bis(arylmethyl)amino, bis(heteroarylmethyl)amino and arylmethyl(heteroarylmethyl)amino; X is selected from the group consisting of oxygen, sulfur, sulfinyl, sulfonyl, carbonyl and amino; R1, R2, R3, R4, R5, R6, R7, R8 and R9 are, for example, hydrogen or alkyl; Ar2 is selected from the group consisting of aryl and heteroaryl; p is an integer of from 0 to 6, inclusive; and, q is an integer of from 0 to 14, inclusive.Type: GrantFiled: June 6, 1999Date of Patent: March 26, 2002Assignee: NPS Pharmaceuticals, Inc.Inventors: Teruyuki Sakai, Atsuya Takami, Rika Nagao
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Patent number: 5936076Abstract: The present invention relates to the novel .alpha.-galactosylceramide represented by the formula (A): ##STR1## wherein R represents ##STR2## where R.sub.2 represents H or OH and X denotes an integer of 0-26, or R represents --(CH.sub.2).sub.7 CH.dbd.CH(CH.sub.2).sub.7 CH.sub.3 and R.sub.1 represents any one of the substituents defined by the following (a)-(e):(a) --CH.sub.2 (CH.sub.2).sub.Y CH.sub.3,(b) --CH(OH)(CH.sub.2).sub.Y CH.sub.3,(c) --CH(OH)(CH.sub.2).sub.Y CH(CH.sub.3).sub.2,(d) --CH.dbd.CH(CH.sub.2).sub.Y CH.sub.3, and(e) --CH(OH)(CH.sub.2).sub.Y CH(CH.sub.3)CH.sub.2 CH.sub.3,wherein Y denotes an integer of 5-17.The present invention also relates to an anti-tumor agent and an immunostimulator comprising one or more of the aforementioned compounds as effective ingredients.Type: GrantFiled: May 25, 1995Date of Patent: August 10, 1999Assignee: Kirin Beer Kabushiki KaishaInventors: Tatsuo Higa, Koji Akimoto, Yasuhiko Koezuka, Teruyuki Sakai, Masahiro Morita, Takenori Natori
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Patent number: 5631238Abstract: Disclosed is a novel spicamycin derivative represented by the formula (I) or a salt thereof: ##STR1## wherein R represents an alkenyl having a given number of carbon atoms, a haloalkyl having a given number of carbon atoms, CH.sub.3 (CH.sub.2).sub.n CH(OH)-- or CH.sub.3 (CH.sub.2).sub.n-1 CH(OH)--CH.sub.2 -- (wherein n denotes an integer of 9-13), an alkyl with a certain group and a given number of carbon atoms, ##STR2## (wherein a denotes 2, and b denotes an integer of 10-15), CH.sub.3 (CH.sub.2).sub.c SO.sub.2 O(CH.sub.2).sub.d --, ##STR3## (wherein c denotes an integer of 0-3 and d denotes an integer of 10-15), (CH.sub.3).sub.3 Si(CH.sub.2).sub.10 --,(CH.sub.3).sub.3 Si--C.tbd.C--(CH.sub.2).sub.8 --, ##STR4## (wherein X represents O or S), and R.sub.1 and R.sub.2 are different from each other and each represents H or OH, which exhibits an excellent antitumor effect and has a high therapeutic index.Type: GrantFiled: April 26, 1995Date of Patent: May 20, 1997Assignee: Kirin Beer Kabushiki KaishaInventors: Noboru Otake, Hiroyuki Kawai, Tomiko Kawasaki, Atsuo Odagawa, Masaru Kamishohara, Teruyuki Sakai
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Patent number: 5461036Abstract: Spicamycin derivative represented by the formula (I) or a salt thereof: ##STR1## wherein R represents specific diverse substituents, for example, a linear alkadienyl having from 11 to 13 carbon atoms, and R.sub.1 and R.sub.2 respectively represent H or OH. Examples of specific compounds are 6-[4'-N-(N'-trans,trans 2,4-tridecadienoylglycyl)spicaminyl-amino]purine, and 6-[4'-N-(N'-trans,trans-2,4 dodecadienyoly glycyl) spicaminyl-amino]purine. Comopunds according to this invention are useful as a pharmaceutical for inhibition of a tumor, for example, human colon cancer.Type: GrantFiled: July 8, 1992Date of Patent: October 24, 1995Assignee: Kirin Beer Kabushiki KaishaInventors: Noboru Otake, Hiroyuki Kawai, Tomiko Kawasaki, Atsuo Odagawa, Masaru Kamishohara, Teruyuki Sakai