Abstract: Disclosed is a coating agent that contains a polyorganosiloxane (1) represented by the following general formula (1), a polydiorganosiloxane (2) represented by the following general formula (2), and either one of an amino group-containing polyorganosiloxane (3) represented by the following general formula (3) and a hydroxy group-containing polyorganosiloxane (4) represented by the following general formula (4). A coating agent having improved piecing properties and a medical instrument (for example, a needle) surface-treated (coated) with the coating agent are provided.

Abstract: A coating agent that has excellent durability and a medical instrument (for example, a needle) that has been coated with the coating agent, are provided. The coating agent includes a condensate (1) of a compound represented by the following general formula (1-1) with a compound represented by the following general formula (1-2), a polydiorganosiloxane (2), and an amino-group-containing polyorganosiloxane (3). The content ratio of the polydiorganosiloxane (2) is 30 to 75 mass %, based on the total mass of the condensate (1), the polydiorganosiloxane (2), and the amino-group-containing polyorganosiloxane (3).

Abstract: A coating agent that has enhanced durability and a medical instrument (for example, a needle) that has been coated with the coating agent, are provided. The coating agent includes a hydroxyl-group-containing polyorganosiloxane represented by the following general formula (1), a polydiorganosiloxane represented by the following general formula (2), and an amino-group-containing polyorganosiloxane represented by the following general formula (3). The polydiorganosiloxane (2) is contained in a proportion of a mass ratio to the amino-group-containing polyorganosiloxane (3) of from 0.7:1 to 3.0:1. The hydroxyl-group-containing polyorganosiloxane (1) is contained in a proportion of 2.4 to 5.5 mass %, based on the total mass of the hydroxyl-group-containing polyorganosiloxane (1), the polydiorganosiloxane (2) and the amino-group-containing polyorganosiloxane (3).

Abstract: Disclosed is a coating agent that contains a polyorganosiloxane (1) represented by the following general formula (1), a polydiorganosiloxane (2) represented by the following general formula (2), and either one of an amino group-containing polyorganosiloxane (3) represented by the following general formula (3) and a hydroxy group-containing polyorganosiloxane (4) represented by the following general formula (4). A coating agent having improved piecing properties and a medical instrument (for example, a needle) surface-treated (coated) with the coating agent are provided.

Abstract: A coating agent that has enhanced durability and a medical instrument (for example, a needle) that has been coated with the coating agent, are provided. The coating agent includes a hydroxyl-group-containing polyorganosiloxane represented by the following general formula (1), a polydiorganosiloxane represented by the following general formula (2), and an amino-group-containing polyorganosiloxane represented by the following general formula (3). The polydiorganosiloxane (2) is contained in a proportion of a mass ratio to the amino-group-containing polyorganosiloxane (3) of from 0.7:1 to 3.0:1. The hydroxyl-group-containing polyorganosiloxane (1) is contained in a proportion of 2.4 to 5.5 mass %, based on the total mass of the hydroxyl-group-containing polyorganosiloxane (1), the polydiorganosiloxane (2) and the amino-group-containing polyorganosiloxane (3).

Abstract: A coating agent that has excellent durability and a medical instrument (for example, a needle) that has been coated with the coating agent, are provided. The coating agent includes a condensate (1) of a compound represented by the following general formula (1-1) with a compound represented by the following general formula (1-2), a polydiorganosiloxane (2), and an amino-group-containing polyorganosiloxane (3). The content ratio of the polydiorganosiloxane (2) is 30 to 75 mass %, based on the total mass of the condensate (1), the polydiorganosiloxane (2), and the amino-group-containing polyorganosiloxane (3).

Abstract: An applicator is inserted into a living body and applies mixed solution to a region in the living body. The applicator includes a nozzle including an elongated nozzle main body to which gas and a plurality of kinds of liquids are supplied and a nozzle head at a distal end of the nozzle main body and configured to jet A mixed solution of the gas and the liquids supplied to the nozzle main body, and a sheath in which the nozzle main body is fitted for relative movement along a longitudinal axial direction of the nozzle main body. At least two crushed portions are provided contiguously to each other at a proximal end portion of the nozzle main body at the opposite side to the nozzle head such that deformation directions thereof with respect to an axial line of the nozzle main body are different from each other.

Abstract: A double-ended needle and a mixing instrument which are capable of suppressing a reverse flow of a solution are provided. A double-ended needle which constitutes part of a mixing instrument includes a first puncture portion and a second puncture portion having inner cavities thereof communicating with each other, an inner cavity of the first puncture portion and an inner cavity of the second puncture portion communicate with each other, and the lateral cross-sectional area of the inner cavity of the first puncture portion is smaller than the lateral cross-sectional area of the inner cavity of the second puncture portion.

Abstract: A method for producing an active esterified polysaccharide, the method including: subjecting a carboxy group of a carboxy group-containing polysaccharide and an agent for introducing an electrophilic group, to an esterification reaction, wherein an active esterified polysaccharide is formed; bringing the active esterified polysaccharide into contact with a polyvalent carboxylic acid; and after the active esterified polysaccharide is brought into contact with the polyvalent carboxylic acid, precipitating and collecting the resulting active esterified polysaccharide.

Abstract: A visually observable material for medical treatment, which is preferable as an adhesion preventive material and a hemostatic material for biological organisms includes a crosslinking composition comprising at least two components of a crosslinking polysaccharide derivative with an active ester group reactive with active hydrogen in the co-presence of an alkali, where the active ester group is preliminarily introduced in a side chain of a polysaccharide and the crosslinking polysaccharide derivative is not yet crosslinked, and a carbonate including at least one type of carbonate generating divalent carbonate ion in an amount at a mass ratio of 0.03 or more to the polysaccharide derivative.

Abstract: A sprayer includes a nozzle through which gas is to be ejected with positiveness and uniformity. The sprayer is provided with a nozzle having inner tubes through the interior of which liquid is to pass and an outer tube receiving the inner tubes therein and allowing gas to pass through a space defined with the inserted inner tubes. The inner tubes have respective liquid orifices through which liquids are to be ejected. The outer tube is arranged therein with the liquid orifices and a gas orifice for ejecting gas. When the nozzle is viewed from front, the outer peripheries of the liquid orifices each assume a circular form while the inner peripheries of the gas orifices are differently shaped to provide plural point contact between the outer periphery of the liquid orifice and the inner periphery of the gas orifice.

Abstract: A sprayer includes a nozzle through which gas is to be ejected with positiveness and uniformity. The sprayer is provided with a nozzle having inner tubes through the interior of which liquid is to pass and an outer tube receiving the inner tubes therein and allowing gas to pass through a space defined with the inserted inner tubes. The inner tubes have respective liquid orifices through which liquids are to be ejected. The outer tube is arranged therein with the liquid orifices and a gas orifice for ejecting gas. When the nozzle is viewed from front, the outer peripheries of the liquid orifices each assume a circular form while the inner peripheries of the gas orifices are differently shaped to provide plural point contact between the outer periphery of the liquid orifice and the inner periphery of the gas orifice.

Abstract: An injection needle that can reduce the pain associated with piercing a patient's skin with a needle. The needle has a needle tip provided by forming at least two or more ground surfaces after a first ground surface is formed at the tip of a needle tube. The needle tip is not present on a central plane, which is the plane that crosses vertically the first ground surface and includes a central axis of the needle tube.

Abstract: A poly-(?-hydroxy acid) composition including a poly-(?-hydroxy acid), and an amino acid, and a method of producing a molded article using the poly-(?-hydroxy acid) composition.

Abstract: An injection needle has a puncture section having a small diameter that does not give a patient pain, injury, etc. and, moreover, does not make a patient feel fear and anxiety, a base end section with a large diameter to achieve a required flow rate and strength, and a tapered section connecting the puncture section and the base end section. The injection needle and a liquid introducing instrument can eliminate pain caused by a tapered section, and excellent puncture can be made with the needle and the instrument. An injection needle (1) has a puncture section (2) provided with a needle point that can be punctured into a living body, a base end section (3) having an outer and an inner diameter larger than the puncture section (2), a tapered section (4) connecting the puncture section (2) and the base end section (3). The tapered section (4) has smaller puncture resistance than the puncture section (2), or specifically, taper angle (A) is equal to or less than 2 degrees.

Abstract: An injection needle (1), comprising a needle tip (5) provided by forming at least two or more ground surfaces (3b, 3c) after a first ground surface (3a) is formed at the tip of a needle tube (2), characterized in that the needle tip (5) is not present on a central plane (6), where a plane vertically crossing the first ground surface (3a) and including the center axis (8) of the needle tube (2) is the central plane (6), whereby the injection needle can reduce boring pain provided to a patient when the needle is pierced into a skin.