Patents by Inventor Tesfai Sebhatu

Tesfai Sebhatu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150283257
    Abstract: Naloxol-polyethylene glycol conjugates of the formula: are provided in oxalate or phosphate salt forms including crystalline forms. Methods of preparing the salt forms and pharmaceutical compositions comprising the salt forms are also provided.
    Type: Application
    Filed: March 11, 2015
    Publication date: October 8, 2015
    Inventors: Bengt Aslund, Carl-Johan Aurell, Martin Hans Bohlin, Tesfai Sebhatu, Bo lngvar Ymen, Eric Thomas Healy, David Richard Jensen, David Thomas Jonaitis, Stephan Parent
  • Patent number: 9149539
    Abstract: Naloxol-polyethylene glycol conjugates of the formula: are provided in oxalate or phosphate salt forms including crystalline forms. Methods of preparing the salt forms and pharmaceutical compositions comprising the salt forms are also provided.
    Type: Grant
    Filed: March 11, 2015
    Date of Patent: October 6, 2015
    Assignees: ASTRAZENECA AB, NEKTAR THERAPEUTICS
    Inventors: Bengt Aslund, Carl-Johan Aurell, Martin Hans Bohlin, Tesfai Sebhatu, Bo Ingvar Ymen, Eric Thomas Healy, David Richard Jensen, David Thomas Jonaitis, Stephan Parent
  • Patent number: 9012469
    Abstract: Naloxol-polyethlyene glycol conjugates of the formula: are provided in oxalate or phosphate salt forms including crystalline forms. Methods of preparing the salt forms and pharmaceutical compositions comprising the salt forms are also provided.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: April 21, 2015
    Assignees: AstraZeneca AB, Nektar Therapeutics
    Inventors: Bengt Leonard Åslund, Carl-Johan Aurell, Martin Hans Bohlin, Eric Thomas Healy, David Richard Jensen, David Thomas Jonaitis, Stephan Parent, Tesfai Sebhatu, Bo Ingvar Ymén
  • Publication number: 20150038524
    Abstract: Naloxol-polyethylene glycol conjugates of the formula: are provided in oxalate or phosphate salt forms including crystalline forms. Methods of preparing the salt forms and pharmaceutical compositions comprising the salt forms are also provided.
    Type: Application
    Filed: September 29, 2011
    Publication date: February 5, 2015
    Applicant: ASTRAZENECA INTELLECTUAL PROPERTY
    Inventors: Bengt Leonard Aslund, Carl-Johan Aurell, Martin Hans Bohlin, David Richard Jensen, David Thomas Jonaitis, Eric Thomas Healy, Bo Ingvar Ymén, Stephan Parent, Tesfai Sebhatu
  • Publication number: 20120115865
    Abstract: The present invention relates to new pharmaceutically acceptable salts of 2-hydroxy-3-[5-(morpholin-4-yl-methyl)pyridin-2-yl]1H-indole-5-carbonitrile, processes for their preparations, pharmaceutical formulations containing said salts and to the use of said active salts in therapy, and particularly to GSK3 related disorders.
    Type: Application
    Filed: January 31, 2007
    Publication date: May 10, 2012
    Inventors: Anna-Lena Berg, Ratan Bhat, Tesfai Sebhatu, Erica Stahle
  • Patent number: 8017785
    Abstract: Phosphoric acid, edisylic acid (1,2-ethanedisulfonic acid), citric acid, orotic acid (uracil-6-carboxylic acid), R-mandelic acid, sulfuric acid, 1,5-naphthalenedisulfonic acid, D-aspartic acid, and lysine monohydrochloride salts of (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin)yl]-4-penten-2-amine, and methods for their preparation, pharmaceutical compositions comprising said salts, and use, are disclosed. The salts can be administered to patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, to treat and/or prevent such disorders.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: September 13, 2011
    Assignees: AstraZeneca AB, Targacept, Inc.
    Inventors: Caroline Ericsson, Martin Bohlin, Tesfai Sebhatu, Gary M. Dull, Julio A. Munoz, Craig H. Miller
  • Patent number: 8008294
    Abstract: The salt, the 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]1H-indole-5-carbonitrile citrate, a process for its preparation, pharmaceutical formulations containing it and the use of it in therapy, and particularly in the therapy of GSK3 related conditions and disorders.
    Type: Grant
    Filed: January 31, 2007
    Date of Patent: August 30, 2011
    Assignee: AstraZeneca AB
    Inventors: Tesfai Sebhatu, Erica Ståhle
  • Publication number: 20100267720
    Abstract: The present invention relates to new crystalline forms of 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]1H-indole-5-carbonitrile citrate, a Form D and a Form E, respectively, a process for their preparations, pharmaceutical formulations containing said compounds and to the use of said active compounds in therapy, and particularly to GSK3 related conditions and disorders.
    Type: Application
    Filed: July 29, 2008
    Publication date: October 21, 2010
    Applicant: ASTRAZENECA AB
    Inventors: Anders Erikson, Veronica Profir, Tesfai Sebhatu, Erica Tjerneld
  • Publication number: 20100249196
    Abstract: Phosphoric acid, edisylic acid (1,2-ethanedisulfonic acid), citric acid, orotic acid (uracil-6-carboxylic acid), R-mandelic acid, sulfuric acid, 1,5-naphthalenedisulfonic acid, D-aspartic acid, and lysine monohydrochloride salts of (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin)yl]-4-penten-2-amine, and methods for their preparation, pharmaceutical compositions comprising said salts, and use, are disclosed. The salts can be administered to patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, to treat and/or prevent such disorders.
    Type: Application
    Filed: May 8, 2007
    Publication date: September 30, 2010
    Applicants: ASTRAZENECA AB, TARGACEPT, INC.
    Inventors: Martin Hans Bohlin, Gary M. Dull, Caroline Eriksson, Craig H. Miller, Julio A. Munoz, Tesfai Sebhatu
  • Publication number: 20090023732
    Abstract: The salt, the 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]1H-indole-5-carbonitrile citrate, a process for its preparation, pharmaceutical formulations containing it and the use of it in therapy, and particularly in the therapy of GSK3 related conditions and disorders.
    Type: Application
    Filed: January 31, 2007
    Publication date: January 22, 2009
    Applicant: AstraZeneca AB
    Inventors: Anna-Lena Berg, Ratan Bhat, Tesfai Sebhatu, Erica Stahle
  • Patent number: 7459463
    Abstract: The present invention relates to novel crystalline forms of 2,3-dimethyl-8-(2,6 -dimethylbenzylamino)-N-hydroxyethyl-imidazo[1,2-a]pyridine-6-carboxamide mesylate salt and to mixture thereof. Further, the present invention also relates to processes for obtaining them, the use of said compounds for the treatment of gastrointestinal disorders, and pharmaceutical compositions containing them.
    Type: Grant
    Filed: December 16, 2004
    Date of Patent: December 2, 2008
    Assignee: AstraZeneca AB
    Inventors: Lars Lilljequist, Maria Lindkvist, Peter Nordberg, Ursula Pettersson, Tesfai Sebhatu
  • Publication number: 20070203137
    Abstract: The present invention relates to a new pharmaceutically acceptable salt, the 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]1H-indole-5-carbonitrile citrate, a process for its preparation, pharmaceutical formulations containing said salt and to the use of said active salt in therapy, and particularly to GSK3 related conditions and disorders.
    Type: Application
    Filed: February 2, 2007
    Publication date: August 30, 2007
    Applicant: ASTRAZENECA AB
    Inventors: Tesfai Sebhatu, Erica Stahle
  • Publication number: 20070112021
    Abstract: The present invention relates to novel crystalline forms of 2,3-dimethyl-8-(2,6-dimethylbenzylamino)-N-hydroxyethyl-imidazo[1,2-a]pyridine-6-carboxamide mesylate salt and to mixture thereof. Further, the present invention also relates to processes for obtaining them, the use of said compounds for the treatment of gastrointestinal disorders, and pharmaceutical compositions containing them.
    Type: Application
    Filed: December 16, 2004
    Publication date: May 17, 2007
    Applicant: TRAZENECA AB
    Inventors: Lars Lilljequist, Maria Lindkvist, Peter Nordberg, Ursula Pettersson, Tesfai Sebhatu