Patents by Inventor Tesfaye Mersha

Tesfaye Mersha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for diagnosing and managing treatment of atopic dermatitis
    Patent number: 11376261
    Abstract: Provided herein is a method of diagnosing and treating a subject suffering from atopic dermatitis (AD), the method comprising: (a) obtaining a skin biopsy from a subject suspected of suffering from AD; (b) determining a level of RNA expression in the skin biopsy of genes selected from the 89ADGES gene panel; (c) comparing the determined level of RNA expression of the selected genes to the level of RNA expression of the selected genes in a reference sample comprising RNA expression products from normal healthy skin cells; (d) diagnosing the subject as suffering from AD when specific genes are up-regulated compared to the reference sample and when specific genes are down-regulated compared to the reference sample; and (e) treating the subject with a therapy effective for the treatment of AD. Methods of managing treatment of a subject suffering from AD are also provided.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: July 5, 2022
    Assignees: University of Cincinnati, Children's Hospital Medical Center
    Inventors: Debajyoti Ghosh, Tesfaye Mersha, Jonathan A. Bernstein
  • Methods for Diagnosing and Managing Treatment of Atopic Dermatitis
    Publication number: 20190183904
    Abstract: Provided herein is a method of diagnosing and treating a subject suffering from atopic dermatitis (AD), the method comprising: (a) obtaining a skin biopsy from a subject suspected of suffering from AD; (b) determining a level of RNA expression in the skin biopsy of genes selected from the 89ADGES gene panel; (c) comparing the determined level of RNA expression of the selected genes to the level of RNA expression of the selected genes in a reference sample comprising RNA expression products from normal healthy skin cells; (d) diagnosing the subject as suffering from AD when specific genes are up-regulated compared to the reference sample and when specific genes are down-regulated compared to the reference sample; and (e) treating the subject with a therapy effective for the treatment of AD. Methods of managing treatment of a subject suffering from AD are also provided.
    Type: Application
    Filed: December 18, 2018
    Publication date: June 20, 2019
    Applicants: University of Cincinnati, Cincinnati Children's Hospital Medical Center
    Inventors: Debajyoti Ghosh, Tesfaye Mersha, Jonathan A. Bernstein