Patents by Inventor Teshome Mebatsion

Teshome Mebatsion has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified Marek's Disease Virus, and Vaccines Made Therefrom
    Publication number: 20230310589
    Abstract: The present invention provides an effective vaccine for Marek's disease, which may be prepared using a recombinant Marek's Disease Virus (MDV), strain CVI988, having been transformed with a foreign DNA construct that includes a long terminal repeat sequence of a reticuloendotheliosis virus. This safe viral agent elicits a highly protective immune response in a chicken against virulent MDV challenge without causing a significant degree of pathogenicity. Suitable formulations of the vaccine for use in chickens include an effective immunization dosage of this novel viral agent, along with a pharmaceutically acceptable carrier or diluent.
    Type: Application
    Filed: November 23, 2022
    Publication date: October 5, 2023
    Applicant: Boehringer Ingelheim Animal Health USA Inc.
    Inventors: Joyce PRITCHARD, Teshome MEBATSION, Michel BUBLOT
  • RECOMBINANT HVT VECTORS EXPRESSING MULTIPLE ANTIGENS OF AVIAN PATHOGENS AND USES THEREOF
    Publication number: 20230175017
    Abstract: The invention relates to a bonding and forming device for an inner box of a paper box and surface paper.
    Type: Application
    Filed: July 15, 2022
    Publication date: June 8, 2023
    Applicant: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.
    Inventors: Michel Bublot, Teshome Mebatsion, Joyce Pritchard, Perry Linz, Aemro Kassa
  • Modified Marek's disease virus, and vaccines made therefrom
    Patent number: 11510978
    Abstract: The present invention provides an effective vaccine for Marek's disease, which may be prepared using a recombinant Marek's Disease Virus (MDV), strain CVI988, having been transformed with a foreign DNA construct that includes a long terminal repeat sequence of a reticuloendotheliosis virus. This safe viral agent elicits a highly protective immune response in a chicken against virulent MDV challenge without causing a significant degree of pathogenicity. Suitable formulations of the vaccine for use in chickens include an effective immunization dosage of this novel viral agent, along with a pharmaceutically acceptable carrier or diluent.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: November 29, 2022
    Assignee: Boehringer Ingelheim Animal Health USA Inc.
    Inventors: Joyce Pritchard, Teshome Mebatsion, Michel Bublot
  • Recombinant HVT vectors expressing multiple antigens of avian pathogens and uses thereof
    Patent number: 11421249
    Abstract: The present invention provides recombinant herpesvirus of turkeys (HVT) vectors that contain and express antigens of avian pathogens, compositions comprising the recombinant HVT vectors and polyvalent vaccines comprising the recombinant HVT vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant HVT vectors.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: August 23, 2022
    Assignee: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.
    Inventors: Michel Bublot, Teshome Mebatsion, Joyce Pritchard, Perry Linz, Aemro Kassa
  • Recombinant vectors expressing antigens of avian influenza virus and uses thereof
    Patent number: 11058761
    Abstract: The present invention provides recombinant viral vectors that contain and express antigens of avian pathogens, compositions comprising the recombinant viral vectors, polyvalent vaccines comprising the recombinant viral vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant viral vectors.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: July 13, 2021
    Inventors: Teshome Mebatsion, Joyce Pritchard, David Swayne
  • Recombinant viral vector systems expressing exogenous feline paramyxovirus genes and vaccines made therefrom
    Patent number: 11033616
    Abstract: The present invention relates to exogenous feline paramyxovirus genes, which are expressed from recombinant viral vector systems.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: June 15, 2021
    Inventors: Hervé Poulet, Veljko Nikolin, Abraham Johannes De Smit, Teshome Mebatsion
  • RECOMBINANT HVT VECTORS EXPRESSING MULTIPLE ANTIGENS OF AVIAN PATHOGENS AND USES THEREOF
    Publication number: 20210010033
    Abstract: The present invention provides recombinant herpesvirus of turkeys (HVT) vectors that contain and express antigens of avian pathogens, compositions comprising the recombinant HVT vectors and polyvalent vaccines comprising the recombinant HVT vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant HVT vectors.
    Type: Application
    Filed: September 28, 2020
    Publication date: January 14, 2021
    Applicant: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.
    Inventors: Michel Bublot, Teshome Mebatsion, Joyce Pritchard, Perry Linz, Aemro Kassa
  • Recombinant HVT vectors expressing multiple antigens of avian pathogens and uses thereof
    Patent number: 10822620
    Abstract: The present invention provides recombinant herpesvirus of turkeys (HVT) vectors that contain and express antigens of avian pathogens, compositions comprising the recombinant HVT vectors and polyvalent vaccines comprising the recombinant HVT vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant HVT vectors.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: November 3, 2020
    Assignee: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.
    Inventors: Michel Bublot, Teshome Mebatsion, Joyce Pritchard, Perry Linz, Aemro Kassa
  • PRRSV minor protein-containing recombinant viral vectors and methods of making and use thereof
    Patent number: 10751407
    Abstract: The present invention encompasses recombinant porcine reproductive and respiratory syndrome virus (PRRSV) vaccines or compositions. In particular, the invention encompasses recombinant adenovirus vectors encoding and expressing PRRSV gp2, gp3, gp4, gp5a, gp5 and/or E antigens, proteins, epitopes or immunogens. Such vaccines or compositions can be used to protect animals from PRRSV.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: August 25, 2020
    Assignee: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.
    Inventors: Teshome Mebatsion, Aemro Kassa, Taejoong Kim
  • RECOMBINANT VIRAL VECTOR SYSTEMS EXPRESSING EXOGENOUS FELINE PARAMYXOVIRUS GENES AND VACCINES MADE THEREFROM
    Publication number: 20200206339
    Abstract: The present invention relates to exogenous feline paramyxovirus genes, which are expressed from recombinant viral vector systems.
    Type: Application
    Filed: February 20, 2019
    Publication date: July 2, 2020
    Inventors: Hervé POULET, Veljko NIKOLIN, Abraham Johannes DE SMIT, Teshome MEBATSION
  • Attenuated swine influenza vaccines and methods of making and use thereof
    Patent number: 10548967
    Abstract: This disclosure provides attenuated swine influenza strains, particularly those produced via a reverse genetics approach, compositions comprising same, and methods of production and use thereof.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: February 4, 2020
    Assignee: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.
    Inventors: Teshome Mebatsion, Taejoong Kim, Paul Michael Dorr, Martin Leonardo Liebstein-Bellia, Alton Timothy Leard
  • RECOMBINANT HVT VECTORS EXPRESSING MULTIPLE ANTIGENS OF AVIAN PATHOGENS AND USES THEREOF
    Publication number: 20190249196
    Abstract: The present invention provides recombinant herpesvirus of turkeys (HVT) vectors that contain and express antigens of avian pathogens, compositions comprising the recombinant HVT vectors and polyvalent vaccines comprising the recombinant HVT vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant HVT vectors.
    Type: Application
    Filed: April 24, 2019
    Publication date: August 15, 2019
    Applicant: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.
    Inventors: Michel Bublot, Teshome Mebatsion, Joyce Pritchard, Perry Linz, Aemro Kassa
  • Modified Marek's Disease Virus, and Vaccines Made Therefrom
    Publication number: 20190216920
    Abstract: The present invention provides an effective vaccine for Marek's disease, which may be prepared using a recombinant Marek's Disease Virus (MDV), strain CVI988, having been transformed with a foreign DNA construct that includes a long terminal repeat sequence of a reticuloendotheliosis virus. This safe viral agent elicits a highly protective immune response in a chicken against virulent MDV challenge without causing a significant degree of pathogenicity. Suitable formulations of the vaccine for use in chickens include an effective immunization dosage of this novel viral agent, along with a pharmaceutically acceptable carrier or diluent.
    Type: Application
    Filed: January 30, 2019
    Publication date: July 18, 2019
    Applicant: Boehringer Ingelheim Animal Health USA Inc.
    Inventors: Joyce Pritchard, Teshome Mebatsion, Michel Bublot
  • Hendra virus recombinant compositions and uses thereof
    Patent number: 10350287
    Abstract: The present invention provides vectors that contain and express in vivo or in vitro one or more Hendra virus polypeptides or antigens that elicit an immune response in animal or human against Hendra virus and Nipah virus, compositions comprising said vectors and/or Hendra virus polypeptides, methods of vaccination against Hendra virus and Nipah virus, and kits for use with such methods and compositions.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: July 16, 2019
    Assignee: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.
    Inventors: Jean-Christophe Audonnet, Jules Maarten Minke, Teshome Mebatsion, Catherine Charreyre
  • Recombinant HVT vectors expressing multiple antigens of avian pathogens and uses thereof
    Patent number: 10323257
    Abstract: The present invention provides recombinant herpesvirus of turkeys (HVT) vectors that contain and express antigens of avian pathogens, compositions comprising the recombinant HVT vectors and polyvalent vaccines comprising the recombinant HVT vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant HVT vectors.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: June 18, 2019
    Assignee: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.
    Inventors: Michel Bublot, Teshome Mebatsion, Joyce Pritchard, Perry Linz, Aemro Kassa
  • PRRSV minor protein-containing recombinant viral vectors and methods of making and use thereof
    Publication number: 20180243398
    Abstract: The present invention encompasses recombinant porcine reproductive and respiratory syndrome virus (PRRSV) vaccines or compositions. In particular, the invention encompasses recombinant adenovirus vectors encoding and expressing PRRSV gp2, gp3, gp4, gp5a, gp5 and/or E antigens, proteins, epitopes or immunogens. Such vaccines or compositions can be used to protect animals from PRRSV.
    Type: Application
    Filed: April 24, 2018
    Publication date: August 30, 2018
    Applicant: MERIAL INC.
    Inventors: Teshome Mebatsion, Aemro Kassa, Taejoong Kim
  • FMDV recombinant vaccines and uses thereof
    Patent number: 10010605
    Abstract: The present invention encompasses FMDV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing FMDV antigens. The invention also encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes or immunogens which can be used to protect animals, in particular ovines, bovines, caprines, or swines, against FMDV.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: July 3, 2018
    Assignee: Merial, Inc.
    Inventors: Jean-Christophe Audonnet, Zahia Hannas-Djebbara, Teshome Mebatsion, Yu-Wei Chiang, Justin Widener, Frédéric Reynard
  • Recombinant poxviral vectors expressing both rabies and OX40 proteins, and vaccines made therefrom
    Patent number: 10006050
    Abstract: The present invention provides vectors that contain and co-express in vivo or in vitro immunogenic polypeptides or antigens together with an OX40L polypeptide, which functions as a genetic adjuvant. Together, the immunogenic polypeptide and the OX40L polypeptide elicit an immune response in animal or human, which is greater than the immune response elicited by the immunogenic polypeptide alone. In a particular example, the invention provides vectors encoding a Rabies G immunogenic polypeptide and a canine OX40L genetic adjuvant, which vectors elicit strong immune responses in canine against rabies virus.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: June 26, 2018
    Assignee: MERIAL, INC.
    Inventors: Teshome Mebatsion, Jules Maarten Minke, Frederic David
  • RECOMBINANT HVT VECTORS EXPRESSING MULTIPLE ANTIGENS OF AVIAN PATHOGENS AND USES THEREOF
    Publication number: 20180163230
    Abstract: The present invention provides recombinant herpesvirus of turkeys (HVT) vectors that contain and express antigens of avian pathogens, compositions comprising the recombinant HVT vectors and polyvalent vaccines comprising the recombinant HVT vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant HVT vectors.
    Type: Application
    Filed: December 13, 2017
    Publication date: June 14, 2018
    Applicant: MERIAL, INC.
    Inventors: Michel Bublot, Teshome Mebatsion, Joyce Pritchard, Perry Linz, Aemro Kassa
  • ATTENUATED SWINE INFLUENZA VACCINES AMD METHODS OF MAKING AND USE THEREOF
    Publication number: 20180147276
    Abstract: This disclosure provides attenuated swine influenza strains, particularly those produced via a reverse genetics approach, compositions comprising same, and methods of production and use thereof.
    Type: Application
    Filed: November 30, 2017
    Publication date: May 31, 2018
    Applicant: MERIAL INC.
    Inventors: Teshome Mebatsion, Taejoong Kim, Paul Michael Dorr, Martin Leonardo Liebstein-Bellia, Alton Timothy Leard