Abstract: The present invention provides a system for managing charitable funds in the ecosystem of corporations, philanthropists, volunteers and non-profits that do social good. Participants may sponsor and cause to issue a finite number of alternative currency units, with varying conditions on use. These units are transferred to volunteers who are supporting a non-profit organization corresponding to the volunteer hours spent by each. The earned units may be gifted by each volunteer to any non-profit organization. Alternatively, the units may be directly granted to a non-profit by corporations and philanthropists corresponding to the units earned by each volunteer. The non-profits voluntarily accept the units and spend it to generate social good. These new methods to pledge, sponsor, issue, buy, sell, earn, store, gift and spend the alternative currency units create a vibrant, community that multiplies the social good generated.

Abstract: The present invention provides a system for managing charitable funds and social currencies in the ecosystem of principals such as corporations and philanthropists, and agents such as volunteers and non-profit organizations that do social good. Principals cause to issue a finite number of social currency units, with varying conditions on use. These units are transferred to volunteers who are supporting a non-profit organization corresponding to the volunteer hours spent by each. The earned units may be gifted by each volunteer to any non-profit organization. Alternatively, the units may be directly granted to a non-profit by corporations and philanthropists corresponding to the units earned by each volunteer. The non-profits voluntarily accept the units and spend it to generate social good.

Abstract: A transgenic fly whose genome is modified to express enhanced levels of glutamate-cysteine ligase (GCL) gene is provided. The fly displays phenotypes associated with Alzheimer's disease (AD). Further, a method for diagnosing AD is provided, which includes assessing enzymatic activities in mitochondrial enzymes. Glutathione pathway are investigated by creating Alzheimer's model Drosophila with over-expression of the GCLc gene, inducing redox stress through sleep deprivation, and analyzing mitochondrial electron transport chain (ETC) using colorimetric enzymatic assays. For prevention of AD, it is proposed that the epigenetic approaches be used to increase glutathione levels in vivo before the onset of AD. For treatment of AD, it is proposed that the glutathione levels be increased by GCLc modulation.