Patents by Inventor Tetsuaki Yamaura
Tetsuaki Yamaura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5965538Abstract: Disclosed is an azapeptide derivative represented by the formula (I): ##STR1## wherein A represents a direct bond, an .alpha.-amino acid or a residue of a dipeptide; R.sup.1 represents a hydrogen atom or a protective group for a terminal amino group; R.sup.2 represents a phenyl group or a phenyl group substituted by one or two substituents selected from the group consisting of a lower alkyl group, halogen atom, hydroxyl group which may be protected, nitro group, amino group which may be protected and perhalo lower alkyl group; and R.sup.3 represents a hydroxyl group or a protective group for a terminal carboxyl group,and a salt thereof, and an agent for curing nervous inflammation of respiratory apparatus, asthma and bronchospasm comprising the azapeptide derivative represented by the formula (I) or a salt thereof as an active ingredient.Type: GrantFiled: August 24, 1998Date of Patent: October 12, 1999Assignee: Fujirebio Inc.Inventors: Yoshiharu Nakashima, Michiyo Hizuka, Yasushi Higashide, Tetsuaki Yamaura, Hiroshi Ikawa
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Patent number: 5859244Abstract: 1,4-dihydropyridine derivatives and optically active 1,4-dihydropyridine derivatives with the following formula, having vasodilating activity based on calcium antagonism, and PAF antaognism, and methods of producing the same are disclosed: ##STR1## wherein (*) indicates a chiral center in the case of the optically active 1,4-dihydropyridine derivatives.Type: GrantFiled: May 13, 1997Date of Patent: January 12, 1999Assignee: Fujirebio, Inc.Inventors: Hiroshi Ikawa, Akiyoshi Kadoiri, Yasuko Konagai, Tetsuaki Yamaura, Noriko Kase
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Patent number: 5837687Abstract: Disclosed is an azapeptide derivative represented by the formula (I): ##STR1## wherein A represents a direct bond, an .alpha.-amino acid or a residue of a dipeptide; R.sup.1 represents a hydrogen atom or a protective group for a terminal amino group;R.sup.2 represents a phenyl group or a phenyl group substituted by one or two substituents selected from the group consisting of a lower alkyl group, halogen atom, hydroxyl group which may be protected, nitro group, amino group which may be protected and perhalo lower alkyl group; and R.sup.3 represents a hydroxyl group or a protective group for a terminal carboxyl group,and a salt thereof, and an agent for curing nervous inflammation of respiratory apparatus, asthma and bronchospasm comprising the azapeptide derivative represented by the formula (I) or a salt thereof as an active ingredient.Type: GrantFiled: March 17, 1995Date of Patent: November 17, 1998Assignee: Fujirebio Inc.Inventors: Yoshiharu Nakashima, Michiyo Hizuka, Yasushi Higashide, Tetsuaki Yamaura, Hiroshi Ikawa
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Patent number: 5763614Abstract: 1,4-dihydropyridine derivatives and optically active 1,4-dihydropyridine derivatives with the following formula, having vasodilating activity based on calcium antagonism, and PAF antagonism, and methods of producing the same are disclosed: ##STR1## wherein (*) indicates a chiral center in the case of the optically active 1,4-dihydropyridine derivatives.Type: GrantFiled: June 10, 1994Date of Patent: June 9, 1998Assignee: Fujirebio Inc.Inventors: Hiroshi Ikawa, Akiyoshi Kadoiri, Yasuko Konagai, Tetsuaki Yamaura, Noriko Kase
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Patent number: 5696268Abstract: 1,4-dihydropyridine derivatives and optically active 1,4-dihydropyridine derivatives with the following formula, having vasodilating activity based on calcium antagonism, and PAF antaognism, and methods of producing the same are disclosed: ##STR1## wherein (*) indicates a chiral center in the case of the optically active 1,4-dihydropyridine derivatives.Type: GrantFiled: June 2, 1995Date of Patent: December 9, 1997Assignee: Fujirebio Inc.Inventors: Hiroshi Ikawa, Akiyoshi Kadoiri, Yasuko Konagai, Tetsuaki Yamaura, Noriko Kase
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Patent number: 5644059Abstract: 1,4-dihydropyridine derivatives and optically active 1,4-dihydropyridine derivatives with the following formula, having vasodilating activity based on calcium antagonism, and PAF antaognism, and methods of producing the same are disclosed: ##STR1## wherein (*) indicates a chiral center in the case of the optically active 1,4-dihydropyridine derivatives.Type: GrantFiled: June 2, 1995Date of Patent: July 1, 1997Assignee: Fujirebio Inc.Inventors: Hiroshi Ikawa, Akiyoshi Kadoiri, Yasuko Konagai, Tetsuaki Yamaura, Noriko Kase
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Patent number: 5571524Abstract: An agent for curing ischemic myocardial disease which contains an effective amount of diadenosine 5',5'"-p.sup.1,p.sup.4 -tetraphosphate (Ap4A) of formula (I): ##STR1## or a pharmaceutically-acceptable salt thereof.Type: GrantFiled: June 6, 1995Date of Patent: November 5, 1996Assignees: Unitika Ltd., Fujirebio, Inc.Inventors: Masafumi Kitakaze, Masatsugu Hori, Takenobu Kamada, Hiroshi Nakajima, Akihiro Sekine, Tetsuaki Yamaura
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Patent number: 5523460Abstract: A 4-fluorobiphenyl derivative of formula (I), which is useful as a cholesterol lowering agent or a lipid lowering agent because of its strong inhibitory effect on HMG-CoA reductase), and which is also useful as an intermediate for producing the above-mentioned cholesterol lowering agent or lipid lowering agent: ##STR1## wherein A is a .omega.-oxycarbonyldihydroxybutyl group, a tetrahydropyranyl group, a .omega.-oxycarbonyl-3-oxobutyl group, a formyl group, or a cyano group; R.sup.1 is a halogen atom, an alkyl group, or a group represented by R.sup.5 O--, wherein R.sup.5 is a hydrogen atom, or an alkyl group; R.sup.2 is a hydrogen atom, an alkyl group; R.sup.3 is a hydrogen atom, or an alkyl group; R.sup.5 and R.sup.2 may form a five-membered ring or a six-membered ring in combination with the oxygen atoms to which R.sup.5 and R.sup.2 are respectively bonded, and R.sup.5 and R.sup.3 may form a five-membered ring or a six-membered ring in combination with the oxygen atom to which R.sup.5 is bonded.Type: GrantFiled: March 28, 1994Date of Patent: June 4, 1996Assignee: Fujirebio Inc.Inventors: Masakatsu Matsumoto, Nobuko Watanabe, Eiko Mori, Miwa Ishihara, Tetsuaki Yamaura, Misao Aoyama, Hiroshi Ikawa, Hisako Kobayashi
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Patent number: 5393780Abstract: A 4-fluorobiphenyl derivative of formula (I): ##STR1## wherein A is a .omega.-oxycarbonyldihydroxybutyl group of formula (II): ##STR2## wherein R.sup.2 is a hydrogen atom, an alkyl group, an alkaline metal or an alkaline earth metal; a tetrahydropyranyl group of formula (III): ##STR3## or a .omega.-oxycarbonyl-3-oxobutyl group of formula (IV): ##STR4## wherein R.sup.3 is an alkyl group; R.sup.1 is an alkyl group. This 4-fluorobiphenyl derivative is useful as an effective component for a cholesterol or lipid lowering agent.Type: GrantFiled: March 25, 1994Date of Patent: February 28, 1995Assignee: Fujirebio Inc.Inventors: Masakatsu Matsumoto, Nobuko Watanabe, Eiko Mori, Miwa Ishihara, Tetsuaki Yamaura, Misao Aoyama, Hiroshi Ikawa, Hisako Kobayashi
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Patent number: 5367081Abstract: 1,4-dihydropyridine derivatives and optically active 1,4-dihydropyridine derivatives with the following formula, having vasodilating activity based on calcium antagonism, and PAF antaognism, and methods of producing the same are disclosed: ##STR1## wherein (*) indicates a chiral center in the case of the optically active 1,4-dihydropyridine derivatives.Type: GrantFiled: November 29, 1991Date of Patent: November 22, 1994Assignee: Fujirebio Inc.Inventors: Hiroshi Ikawa, Akiyoshi Kadoiri, Yasuko Konagai, Tetsuaki Yamaura, Noriko Kase
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Patent number: 5324728Abstract: A naphthoic acid derivative represented by the following general formula or a salt thereof: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each independently a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, a lower alkanoyloxy group, a hydroxy-lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkanoyloxy-lower alkyl group or an aralkyloxy group;R.sub.4 is a hydrogen atom or a lower alkyl group;R.sub.5 is a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaromatic group;X is a group ##STR2## a cycloalkylene group, a bivalent nitrogen-containing heterocyclic group, or a group ##STR3## --R.sub.8 --NH-- or --NH--R.sub.8, where R.sub.6 and R.sub.7 are each a hydrogen atom or a lower alkyl group and R.sub.8 is a cycloalkylene group, or R.sub.6 and R.sub.7, together with R.sub.4, may form an alkylene group of 1-3 carbon atoms;Y is --S(O).sub.p --, --(CH.sub.2).sub.Type: GrantFiled: December 2, 1991Date of Patent: June 28, 1994Assignee: Fujirebio Inc.Inventors: Yasuo Sekine, Tetsuaki Yamaura, Masato Nishimura, Eri Kojima, Yasuko Emoto, Yasushi Higashide
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Patent number: 5266707Abstract: 4-hydroxytetrahydropyran-2-one and 3,5-Dihydroxyheptanoic acid derivatives of formula (I) and formula (II) have an inhibition effect on HMG-CoA reductase, a cholesterol value reduction effect, and an antioxidation function, thus serving as cholesterol reducing agent or lipid reducing agents: ##STR1## wherein R.sup.1 represents hydrogen, a nitro group, or -N(R.sup.4)R.sup.5 in which R.sup.4 and R.sup.5 each represent an alkyl group, an alkenyl group, an aryl group, an aralkyl group; an acyl group, an aroyl group, a carbamoyl group, or a thiocarbamoyl group, and R.sup.4 and R.sup.5 may be combined to form a cyclic amino group; and R.sup.2 and R.sup.3 each represent hydrogen or an alkyl group; and R.sup.6 represents hydrogen, an alkyl group, an alkali metal, or an alkaline earth metal.Type: GrantFiled: September 17, 1992Date of Patent: November 30, 1993Assignee: Fujirebio Inc.Inventors: Masakatsu Matsumoto, Nobuko Watanabe, Eiko Mori, Tetsuaki Yamaura, Misao Aoyama
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Patent number: 5219841Abstract: The present invention relates to a pharmaceutical composition for treating a heart disease which comprises a therapeutically effective amount of diadenosine 5',5'"-P.sup.1, P.sup.4 -tetraphosphate as an active ingredient in admixture with a pharmaceutically acceptable carrier or diluent. The pharmaceutical composition is particularly characterized by having antiarrhythmic and coronary vasodilative activities. The present invention also relates to a method for treating a subject having a heart disease or particularly arrhythmia, which comprises administering to the subject an effective amount of the pharmaceutical composition.Type: GrantFiled: November 20, 1990Date of Patent: June 15, 1993Assignees: Fujirebio, Inc., Unitika Ltd.Inventors: Niro Inaba, Kunihiro Okamura, Tetsuaki Yamaura
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Patent number: 4912101Abstract: A compound represented by the following formula or a salt thereof ##STR1## wherein each of R.sub.1 and R.sub.2 represents a lower alkyl group, or R.sub.1 and R.sub.2, together with the nitrogen atom to which they are bonded, may form a substituted or unsubstituted, saturated or partially unsaturated 4- to 8-membered heterocyclic group which may contain a hetero atom selected from N, O and S, Y represents a group of the formula --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, and n is 0, 1 or 2. This compound is useful as anti-peptic ulcer agent.Type: GrantFiled: March 9, 1988Date of Patent: March 27, 1990Assignee: Fujirebio Kabushiki KaishaInventors: Nobuhiko Hirakawa, Noriaki Kashiwaba, Hajime Matsumoto, Akihiko Hosoda, Yasuo Sekine, Yoshikazu Isowa, Tetsuaki Yamaura, Akihiro Sekine, Masashi Nishikawa
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Patent number: 4837316Abstract: Alkylamide derivatives having the formula, These compounds have a strong antiulcer action depend on histamine H.sub.2 -receptor antagonistic action and a cytoprotective action upon gastric mucous membrance.Type: GrantFiled: August 27, 1986Date of Patent: June 6, 1989Assignee: Fujirebio Kabushiki KaishaInventors: Yasuo Sekine, Nobuhiro Hirakawa, Noriaki Kashiwaba, Tetsuaki Yamaura, Hisako Harada, Teruo Kutsuma, Hajime Matsumoto, Akihiro Sekine, Yoshikazu Isowa