Abstract: The present invention provides a technology which can perform a precise restoration to a distribution of original information by carrying out an iterative calculation using only a distribution of degraded information. The method according to the present invention performs the restoration to original information based only on degraded information. The method according to the present invention considers the distribution of the degraded information and the distribution of the original information as distributions of probability density functions, and considers a transfer function of a transfer system as a probability density function of a conditional probability.

Abstract: Antimicrobial agent including an artificially synthesized antimicrobial peptide that does not occur naturally is provided by present invention. The peptide included in the antimicrobial agent includes 1 unit, 2 units or more units of sequence(s) or sequence(s) with partial modification, the sequence(s) composed of at least 6 contiguous amino acid residues selected from any one of amino acid sequences: (a) KVQIINKK; (b) SVQIVYKP; (c) QVEVKSEK; (d) KKVAVVRT; (e) KKVAIIRT; (f) KKPTSAK, and the total number of amino acid residues included in 1 unit, 2 units or more units of sequence(s) is 30% or more of the total number of amino acid residues constituting the peptide chain.

Abstract: The present invention provides a technology which precisely restores a distribution of original information by carrying out an iterative calculation based on a distribution of degraded information and a transfer function including a phase characteristic of a transfer system. A method according to the present invention restores the original information using the degraded information and the transfer function in the frequency space. The method according to the present invention considers a distribution of the degraded information and a distribution of the original information as distributions of probability density functions, and considers the transfer function as a probability density function of a conditional probability. The most probable distribution of the original information according to the distribution of the degraded information is acquired by the iterative calculation by means of relational equations based on the Bayes' theorem relating to the probability density functions.

Abstract: Disclosed is a neuronal differentiation inhibitor which comprises at least one peptide capable of inhibiting or controlling the neuronal differentiation of at least one cell capable of being differentiated into a neuronal cell. The peptide is an artificially synthesized peptide which comprises a BC-box derived amino acid sequence comprising at least 10 contiguous amino acid residues selected from an amino acid sequence constituting the BC-box of at least one protein belonging to the elongin A family or comprises an amino acid sequence having a partial modification in the BC-box derived amino acid sequence.

Abstract: The present invention provides a method of transporting a peptide motif of interest into a nucleus of a eukaryotic cell from outside the cell, including: synthesizing a peptide chain having an amino acid sequence constituting the peptide motif of interest at an N-terminal end or a C-terminal end of a cell membrane-permeable nucleolar localization signal sequence defined by the amino acid sequence KKRTLRKNDRKKR (SEQ ID NO: 1); adding the synthesized peptide to a culture medium which includes the eukaryotic cell or a tissue containing the eukaryotic cell; and culturing the eukaryotic cell to which the synthesized peptide is added, or the tissue containing the cell.

Abstract: Antimicrobial peptide provided by present invention is an artificially designed antimicrobial peptide that does not occur naturally, and includes a sequence composed of at least 6 contiguous amino acid residues selected from an amino acid sequence constituting laminin binding site (LBS), or said sequence with one or a plurality of amino acid residue(s) conservatively replaced, and an amino acid sequence that can express antimicrobial activity against at least one kind of bacteria or fungi. It is desirable that the total number of amino acid residues is 100 or less.

Abstract: Artificially synthesized antimicrobial peptide that does not occur naturally is provided by the present invention. The antimicrobial peptide includes one unit, two units or more units of amino acid sequence composed of the following 8 amino acid residues: (R or Q)-(L or F or I)—I—K-(L or F or I or V)-L-Y-Q; and/or, modified sequence composed of said sequence with partial modification.

Abstract: Disclosed is a neuronal differentiation inhibitor which comprises at least one peptide capable of inhibiting or controlling the neuronal differentiation of at least one cell capable of being differentiated into a neuronal cell. The peptide is an artificially synthesized peptide which comprises a BC-box derived amino acid sequence comprising at least 10 contiguous amino acid residues selected from an amino acid sequence constituting the BC-box of at least one protein belonging to the elongin A family or comprises an amino acid sequence having a partial modification in the BC-box derived amino acid sequence.

Abstract: Disclosed is an antiviral agent comprising a non-naturally occurring, artificially synthesized peptide as the main ingredient. The antiviral agent comprises an antiviral peptide, wherein the antiviral peptide has at least one unit of an amino acid sequence constituted by at least five contiguous amino acid residues (which is known as a nuclear localization sequence (NLS)) or an amino acid sequence having a partial modification in the NLS and also having at least one unit of an amino acid sequence constituted by at least five contiguous amino acid residues (which is known as a nuclear export sequence (NES)) or an amino acid sequence having a partial modification in the NES.

Abstract: A neuronal differentiation inducer comprising at least one peptide which can induce the differentiation of at least one cell into a neurocyte. The peptide is an artificially synthesized peptide comprising an amino acid sequence derived from a BC-box of at least one protein belonging to the SOCS protein family or an amino acid sequence having a partial modification in the BC-box-derived amino acid sequence, wherein the BC-box-derived amino acid sequence is composed of at least 10 contiguous amino acid residues selected in the amino acid sequence constituting the BC-box.

Abstract: Antimicrobial peptides provided by the present invention are artificially designed antimicrobial peptides that are not present in nature. Several antimicrobial peptides have, as the amino acid sequence related to the expression of antimicrobial property, a partial amino acid sequence in the ?-domain of human-derived VHL protein. In addition, several antimicrobial peptides have a partial amino acid sequence of SOCS-box of a certain SOCS-box protein.

Abstract: The present invention provides an artificially synthesized antimicrobial polypeptide that does not occur in nature and an antimicrobial agent comprising this polypeptide as the main component. This polypeptide contains in its peptide chain one or more types of nuclear localization signal sequences (NLSs) and/or one or more units of sequences prepared by partially modifying the NLS(s). The one or more units of NLSs and/or modified NLSs contain at least 5 amino acid residues in total and amount to 30% or more of the total amino acid residues constituting the peptide chain.

Abstract: The present invention provides a technology which can perform a precise restoration to a distribution of original information by carrying out an iterative calculation using only a distribution of degraded information. The method according to the present invention performs the restoration to original information based only on degraded information. The method according to the present invention considers the distribution of the degraded information and the distribution of the original information as distributions of probability density functions, and considers a transfer function of a transfer system as a probability density function of a conditional probability.

Abstract: Disclosed is an anti-viral peptide which non-naturally occurs and is artificially synthesized. The peptide has at least one unit of the following amino acid sequence (a) and at least one unit of the following amino acid sequence (b) or (c): (a) an amino acid sequence constituted by at least five contiguous amino acid residues which is known as a nuclear localization sequence (NLS) or an amino acid sequence having a partial modification in the NLS; (b) a conserved sequence of VAP which is an endoplasmic reticulum protein or an amino acid sequence having a partial modification in the conserved sequence; and (C) an amino acid sequence which is known as a FFAT motif found in various lipid-binding proteins or an amino acid sequence having a partial modification in the amino acid sequence.

Abstract: The present invention provides a technology which precisely restores a distribution of original information by carrying out an iterative calculation based on a distribution of degraded information and a transfer function including a phase characteristic of a transfer system. A method according to the present invention restores the original information using the degraded information and the transfer function in the frequency space. The method according to the present invention considers a distribution of the degraded information and a distribution of the original information as distributions of probability density functions, and considers the transfer function as a probability density function of a conditional probability. The most probable distribution of the original information according to the distribution of the degraded information is acquired by the iterative calculation by means of relational equations based on the Bayes' theorem relating to the probability density functions.

Abstract: Antimicrobial peptide provided by present invention is an artificially designed antimicrobial peptide that does not occur naturally, and includes a sequence composed of at least 6 contiguous amino acid residues selected from an amino acid sequence constituting laminin binding site (LBS), or said sequence with one or a plurality of amino acid residue(s) conservatively replaced, and an amino acid sequence that can express antimicrobial activity against at least one kind of bacteria or fungi. It is desirable that the total number of amino acid residues is 100 or less.

Abstract: Antimicrobial agent including an artificially synthesized antimicrobial peptide that does not occur naturally is provided by present invention. The peptide included in the antimicrobial agent includes 1 unit, 2 units or more units of sequence(s) or sequence(s) with partial modification, the sequence(s) composed of at least 6 contiguous amino acid residues selected from any one of amino acid sequences: (a) KVQIINKK; (b) SVQIVYKP; (c) QVEVKSEK; (d) KKVAVVRT; (e) KKVAIIRT; (f) KKPTSAK, and the total number of amino acid residues included in 1 unit, 2 units or more units of sequence(s) is 30% or more of the total number of amino acid residues constituting the peptide chain.

Abstract: Artificially synthesized antimicrobial peptide that does not occur naturally is provided by the present invention. The antimicrobial peptide includes one unit, two units or more units of amino acid sequence composed of the following 8 amino acid residues: (R or Q)-(L or F or I)—I—K-(L or F or I or V)-L-Y-Q; and/or, modified sequence composed of said sequence with partial modification.

Abstract: The present invention provides an artificially synthesized antimicrobial polypeptide that does not occur in nature and an antimicrobial agent comprising this polypeptide as the main component. This polypeptide contains in its peptide chain one or more types of nuclear localization signal sequences (NLSs) and/or one or more units of sequences prepared by partially modifying the NLS(s). The one or more units of NLSs and/or modified NLSs contain at least 5 amino acid residues in total and amount to 30% or more of the total amino acid residues constituting the peptide chain.

Abstract: The present invention provides methods for selecting artificial promotor candidates that reduce the number of promotors required to be evaluated by actual experimentation when designing artificial promotor candidates that are potentially effective for structural genes. In these artificial promotor candidate selection methods, a randomly selected nucleotide sequence is joined upstream of a structural gene (S1). Next, nucleotides are extracted in a predetermined pattern from a designated region containing at least the transcription start site of the joined nucleotide sequence, thereby generating a virtual amino acid sequence, and an index curve is generated from the virtual amino acid sequence (S2, S3). Then, the nucleotide sequence joined upstream of the structural gene is selected as an artificial promotor candidate if the index curve exhibits a sign change near the transcription start site (S4).