Abstract: The metal fine particles 33 are sparsely fixed on the surface of the transparent substrate 32, and the acceptor 35 for attaching the specific ligand is immobilized on the transparent substrate 32 or the metal fine particles 33. The prism 36 is closely attached to the lower surface of the transparent substrate 32, and the excitation light enters the transparent substrate 32 through the prism 36. The incident light is totally reflected at the surface of the transparent substrate 32, and the evanescent light generated at the surface and the metal fine particles 33 locally plasmon resonate. As the evanescent light and the metal fine particles locally plasmon resonate, a strong electric field is enclosed in the vicinity of the metal fine particles.

Abstract: A method of mass-producing minute structures such as biochips, protein chips, quantum dots, and quantum chips involves arranging an antigen two-dimensionally on a board and arranging probes two-dimensionally facing the same direction so that the binding sites of the probes may bind to the antigen. An inorganic substance such as Ni is deposited on the board from the upper side of the probes by sputtering or evaporation to form a thin film layer and on the top surface of the flatly formed thin film layer, a supporting layer is formed by separating out the same inorganic substance using electrotyping. Then, by peeling the thin film layer and the supporting layer off of the board together, the mother stamper having cavities for the patterns of biomolecules is obtained.

Abstract: At both ends of a waveguide 43 having a plurality of cores 51, light emitting elements 47 and light receiving elements 49 are disposed so as to face end faces of the cores 51. A switch 44 is overlapped over the waveguide 43. In the switch 44, switching windows 52 each can be switched between a state where light propagating through the core 51 is passed and a state where the light is reflected are arranged in the vertical and horizontal directions, and the switching windows 52 are arranged along the top faces of the cores 51. A test board 45 having a plurality of channels 60 in each of which a metallic thin film 61 is formed is disposed over the switch 44, and receptors 62 are fixed on the metallic thin film 61 in the channels 60. A specimen containing a specific ligand is passed in each of the channels 60.

Abstract: In a surface plasmon resonance sensor including a chip with a substrate 102 and a metal layer 103, a prism 104, an optical system 105 serving as a light source, and a light detector 106, the metal layer 103 is configured by a flat part 109 formed into a thin film, and convex parts formed from metal particles 110 and the like arranged spaced apart from each other. When light enters the metal layer 103 of such configuration, resonance angle arising from the flat part 109 and the convex parts are respectively obtained. The change in index of refraction of a medium contacted by the metal layer is detected from such resonance angle.

Abstract: The metal fine particles 33 are sparsely fixed on the surface of the transparent substrate 32, and the acceptor 35 for attaching the specific ligand is immobilized on the transparent substrate 32 or the metal fine particles 33. The prism 36 is closely attached to the lower surface of the transparent substrate 32, and the excitation light enters the transparent substrate 32 through the prism 36. The incident light is totally reflected at the surface of the transparent substrate 32, and the evanescent light generated at the surface and the metal fine particles 33 locally plasmon resonate. As the evanescent light and the metal fine particles locally plasmon resonate, a strong electric field is enclosed in the vicinity of the metal fine particles.

Abstract: A substrate for immobilizing biomolecules comprises a chip substrate, a hydrophilic monolayer, and a lipid bilayer, and a biochip comprising the substrate for immobilizing biomolecules on which biomolecules are immobilized. The substrate for immobilizing biomolecules includes a transparent chip substrate, a metal layer provided on the chip substrate, a monolayer provided on the metal layer, and a lipid bilayer provided on the monolayer. The metal layer is composed of fine particles of Au, the monolayer is composed of self-assembled molecules represented by X—(CH2)n—OH (where X is a thiol group), and the lipid bilayer is composed of self-assembled phospholipids. The monolayer and the lipid bilayer are relatively flexibly bound together via hydrogen bonds. In the biochip, a receptor is immobilized on the lipid bilayer via a biorecognition molecule.

Abstract: At both ends of a waveguide 43 having a plurality of cores 51, light emitting elements 47 and light receiving elements 49 are disposed so as to face end faces of the cores 51. A switch 44 is overlapped over the waveguide 43. In the switch 44, switching windows 52 each can be switched between a state where light propagating through the core 51 is passed and a state where the light is reflected are arranged in the vertical and horizontal directions, and the switching windows 52 are arranged along the top faces of the cores 51. A test board 45 having a plurality of channels 60 in each of which a metallic thin film 61 is formed is disposed over the switch 44, and receptors 62 are fixed on the metallic thin film 61 in the channels 60. A specimen containing a specific ligand is passed in each of the channels 60.

Abstract: A method of mass-producing minute structures such as biochips, protein chips, quantum dots, and quantum chips involves arranging an antigen two-dimensionally on a board and arranging probes two-dimensionally facing the same direction so that the binding sites of the probes may bind to the antigen. An inorganic substance such as Ni is deposited on the board from the upper side of the probes by sputtering or evaporation to form a thin film layer and on the top surface of the flatly formed thin film layer, a supporting layer is formed by separating out the same inorganic substance using electrotyping. Then, by peeling the thin film layer and the supporting layer off of the board together, the mother stamper having cavities for the patterns of biomolecules is obtained.