Patents by Inventor Tetsuji Tanimoto
Tetsuji Tanimoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7276343Abstract: The present invention provides a chemiluminescence enhancer treated to retain favorable dispersibility of fine solid carriers and stably exert a chemiluminescence enhancing action. The invention provides a chemiluminescence enhancer used for signal detection in a solid phase immunoassay using antigen or/and antibody immobilized onto fine solid carriers dispersible in a liquid medium, consisting of a water soluble macromolecular quaternary ammonium salt, a quaternary sulfonium salt or a quaternary phosphonium salt in order to enhance emission of light caused by an enzymatic reaction of a chemiluminescent substrate having dioxetane, wherein the chemiluminescence enhancer is given an aggregation inhibition treatment of the fine solid carriers by the treatment with an oxidizing agent or a reducing agent, and a chemiluminescence method and a kit using the chemiluminescence enhancer.Type: GrantFiled: June 24, 2003Date of Patent: October 2, 2007Assignee: Fujirebio Inc.Inventors: Kazushige Moriyama, Tetsuji Tanimoto, Tatsuki Matsuno, Yoshihiro Ashihara
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Publication number: 20070059786Abstract: The present invention provides a chemiluminescence enhancer treated to retain favorable dispersibility of fine solid carriers and stably exert a chemiluminescence enhancing action. The invention provides a chemiluminescence enhancer used for signal detection in a solid phase immunoassay using antigen or/and antibody immobilized onto fine solid carriers dispersible in a liquid medium, consisting of a water soluble macromolecular quaternary ammonium salt, a quaternary sulfonium salt or a quaternary phosphonium salt in order to enhance emission of light caused by an enzymatic reaction of a chemiluminescent substrate having dioxetane, wherein the chemiluminescence enhancer is given an aggregation inhibition treatment of the fine solid carriers by the treatment with an oxidizing agent or a reducing agent, and a chemiluminescence method and a kit using the chemiluminescence enhancer.Type: ApplicationFiled: June 7, 2006Publication date: March 15, 2007Applicant: FUJIREBIO INC.Inventors: Kazushige Moriyama, Tetsuji Tanimoto, Tatsuki Matsuno, Yoshihiro Ashihara
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Publication number: 20050239149Abstract: The present invention provides a chemiluminescence enhancer treated to retain favorable dispersibility of fine solid carriers and stably exert a chemiluminescence enhancing action. The invention provides a chemiluminescence enhancer used for signal detection in a solid phase immunoassay using antigen or/and antibody immobilized onto fine solid carriers dispersible in a liquid medium, consisting of a water soluble macromolecular quaternary ammonium salt, a quaternary sulfonium salt or a quaternary phosphonium salt in order to enhance emission of light caused by an enzymatic reaction of a chemiluminescent substrate having dioxetane, wherein the chemiluminescence enhancer is given an aggregation inhibition treatment of the fine solid carriers by the treatment with an oxidizing agent or a reducing agent, and a chemiluminescence method and a kit using the chemiluminescence enhancer.Type: ApplicationFiled: June 24, 2003Publication date: October 27, 2005Applicant: FUJIREBIO INC.Inventors: Kazushige Moriyama, Tetsuji Tanimoto, Tatsuki Matsuno, Yoshihiro Ashihara
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Patent number: 6794155Abstract: A Treponema pallidum fused antigen in which at least two surface antigens of Treponema pallidum are fused and an assay for anti-Treponema pallidum antibodies, using the above Treponema pallidum fused antigen.Type: GrantFiled: January 18, 2001Date of Patent: September 21, 2004Assignee: Fujirebio Inc.Inventors: Nobuyuki Ise, Takeya Hori, Katsuya Fujimura, Tetsuji Tanimoto, Masahisa Okada
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Patent number: 6589754Abstract: An immunoassay element for quantitatively analyzing a macromolecular antigen by determining the change in enzymatic activity caused by a reaction between the macromolecular polymer antigen and an enzyme-labelled antibody. The immunoassay element comprises a substrate layer containing a non-diffusible substrate which forms a diffusible material in the presence of the enzyme, and a reagent layer containing a fragmenting enzyme for further fragmenting the diffusible material into a lower molecular weight product. Also provided is a process for quantitatively analyzing a macromolecular antigen in a sample by the use of the immunoassay element.Type: GrantFiled: October 8, 1997Date of Patent: July 8, 2003Assignees: Fuji Photo Film Co., Ltd., Fujirebio Inc.Inventors: Toshikage Hiraoka, Tetsuji Tanimoto, Yoshihiko Makino, Tadashi Ninomiya, Hiroshi Shinoki, Yoshihiro Ashihara, Naofumi Hora, Masashi Ogawa
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Patent number: 6248331Abstract: A Treponema pallidum fused antigen in which at least two surface antigens of Treponema pallidum are fused and an assay for anti-Treponema pallidum antibodies, using the above Treponema pallidum fused antigen.Type: GrantFiled: December 26, 1996Date of Patent: June 19, 2001Assignee: Fujirebio, Inc.Inventors: Nobuyuki Ise, Takeya Hori, Katsuya Fujimura, Tetsuji Tanimoto, Masahisa Okada
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Publication number: 20010002311Abstract: A Treponema pallidum fused antigen in which at least two surface antigens of Treponema pallidum are fused and an assay for anti-Treponema pallidum antibodies, using the above Treponema pallidum fused antigen.Type: ApplicationFiled: January 18, 2001Publication date: May 31, 2001Applicant: FUJIREBIO INC.Inventors: Nobuyuki Ise, Takeya Hori, Katsuya Fujimura, Tetsuji Tanimoto, Masahisa Okada
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Patent number: 5603898Abstract: A dry-type analytical element for immunoassay having at least one water-permeable layer for measuring a ligand in a sample according to enzyme immunoassay, which comprises,(A) a water-soluble macromolecular substrate, and(B) an enzyme conjugated with antibody reacting with the ligand in the sample capable to act on the above water-soluble macromolecular substrate. The above analytical element further comprises,(C) a macromolecular antigen which is a conjugate of the ligand or its derivative with a macromolecular compound in the above water-permeable layer of the above dry-type analytical element.The invention can conduct highly sensitive and simple enzyme immunoassay.Type: GrantFiled: December 17, 1992Date of Patent: February 18, 1997Assignees: Fujirejiro Inc., Fuji Photo Film Co., Ltd.Inventors: Yoshihiro Ashihara, Yukio Sudo, Isao Nishizono, Toshikage Hiraoka, Tetsuji Tanimoto, Shigeki Kageyama
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Patent number: 5569589Abstract: An immunoassay element for quantitatively analyzing a ligand by determining the change in enzymatic activity caused by a reaction between the ligand, a linked product of the ligand and a high molecular weight compound and an enzyme-labelled antibody. The immunoassay element comprises a substrate layer containing a non-diffusible substrate which forms a diffusible material in the presence of the enzyme, and a reagent layer containing a fragmenting enzyme for further fragmenting the non-difussible material. Also provided is a process for quantitatively analyzing a ligand contained in a sample by the use of the immunoassay element.Type: GrantFiled: December 7, 1993Date of Patent: October 29, 1996Assignees: Fuji Photo Film Co., Ltd., Fujirebio Inc.Inventors: Toshikage Hiraoka, Tetsuji Tanimoto, Yoshihiko Makino, Tadashi Ninomiya, Naofumi Hora, Yoshihiro Ashihara, Yukio Sudo, Toshihiro Mori
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Patent number: 5470759Abstract: A method for measuring glycated hemoglobin is disclosed, which comprises contacting a sample with an anti-hemoglobin antibody being bound to a solid phase, adding thereto an anti-glycated hemoglobin antibody, and then measuring the anti-glycated hemoglobin antibody bound to the solid phase via glycated hemoglobin and the anti-hemoglobin antibody. A method for measuring glycated hemoglobin is further disclosed, which comprises mixing a sample with particles on which an anti-glycated hemoglobin antibody is bound to cause immunoagglutination reaction. A method for measuring glycated hemoglobin is furthermore disclosed, which comprises mixing a sample with a solution containing a monoclonal antibody specific for glycated hemoglobin, and then measuring the change in the turbidity of the resulting mixture. A method is disclosed for measuring glycated hemoglobin which comprises mixing a sample with unsensitized latex particles and an anti-glycated hemoglobin antibody, to cause immunoagglutination reaction.Type: GrantFiled: June 7, 1993Date of Patent: November 28, 1995Assignee: Fujirebio, Inc.Inventors: Masami Sugiyama, Yoshiaki Uchida, Yoshihiro Kurano, Aiko Tanaka, Tetsuji Tanimoto
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Patent number: 5093081Abstract: A dry-type analytical element for immunoassay having at least one water-permeable layer for measuring a ligand in a sample according to enzyme immunoassay, which comprises,(A) a water-insoluble macromolecular substrate, and(B) an antibody, reacting with the ligand in the sample, conjugated with an enzyme capable of acting on the above water-insoluble macromolecular substrate.The above analytical substance further comprises,(C) a macromolecular substance which is a conjugate of the ligand or its derivative with a macromolecular compound in the above water-permeable layer of the above dry-type analytical element.The invention can conduct a highly sensitive and simple enzyme immunoassay.Type: GrantFiled: June 21, 1989Date of Patent: March 3, 1992Assignees: Fuji Photo Film Co., Ltd., Fujirebio Kabushiki KaishaInventors: Yukio Sudo, Yoshihiro Ashihara, Toshikage Hiraoka, Isao Nishizono, Shigeki Kageyama, Tetsuji Tanimoto