Patents by Inventor Tetsuo Miwa
Tetsuo Miwa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7091247Abstract: A novel biphenyl compound having GPR 14 antagonistic activity. It is a compound represented by the formula (I): wherein R1 represents hydrogen, etc.; X represents 1 to 12 spacers; A represents amino, etc., R2 and R3 each represents a hydrocarbon group, etc.; and rings B and C each represents an optionally further substituted benzene ring, or a salt thereof.Type: GrantFiled: June 28, 2001Date of Patent: August 15, 2006Assignee: Takeda Pharmaceutical Company LimitedInventors: Naoki Tarui, Takashi Santo, Hiroyuki Watanabe, Kazuyoshi Aso, Tetsuo Miwa, Shiro Takekawa
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Patent number: 7087597Abstract: Compounds of the formula wherein R1, R2, R3, R4, X and Y are as defined, which have a superior cGMP specific phosphodiesterase (PDE) inhibitory activity, and can be used as an agent for the treatment of cardiovascular diseases such as angina pectoris, heart failure, cardiac infarction, hypertension, arteriosclerosis, and the like; allergic diseases such as asthma, or disorders of male or female genital function and the like.Type: GrantFiled: October 11, 2000Date of Patent: August 8, 2006Assignee: Takeda Pharmaceutical Company LimitedInventors: Tetsuo Miwa, Mitsuo Yamamoto, Takayuki Doi, Naoki Tarui
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Publication number: 20040106792Abstract: A novel biphenyl compound having GPR 14 antagonistic activity.Type: ApplicationFiled: December 20, 2002Publication date: June 3, 2004Inventors: Naoki Tauri, Takashi Santo, Hiroyuki Watanabe, Kazuyoshi Aso, Tetsuo Miwa, Shiro Takekawa
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Patent number: 6388022Abstract: The present invention provides a linker binding carrier for organic synthesis represented by the formula: —Z—W—(SO2X)m wherein  is a carrier, X is a leaving group, Y is a bond or spacer, Z is a bivalent group, when Z is a bivalent electron attractive group, W is an aromatic ring which may be substituted and when Z is a bivalent non-electron attractive group, W is an aromatic ring which is substituted by an electron attractive group and may be further substituted and m is 1 or 2, or a salt thereof, which is useful for synthesizing a novel organic compound.Type: GrantFiled: August 30, 1999Date of Patent: May 14, 2002Assignee: Takeda Chemical Industires, Ltd.Inventors: Katsunori Nagai, Tetsuo Miwa
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Patent number: 6174877Abstract: A cephem compound of the formula: wherein R1 stands for an optionally substituted lower alkyl group, R2 stands for H or a lower alkyl group, R3 stands for H, an optionally substituted hydrocarbon group, cyano group, a lower alkyloxy group or a lower alkylthio group, and the ring A stands for an optionally substituted non-quaternarized nitrogen-containing heterocyclic ring, provided that, when A is unsubstituted 2-pyridyl group, R3 stands for a group other than hydrogen, or their esters or salts, has excellent antibacterial activities, oral absorbability and stability, and is useful as an antibacterial agent.Type: GrantFiled: July 10, 1998Date of Patent: January 16, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Yukio Ishibashi, Shinichi Imamura, Tetsuo Miwa
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Patent number: 5539113Abstract: A process of making a compound of the formula ##STR1## wherein the ring A is a pyrrole or pyrroline ring, X is an amino group or a hydroxyl group, Y is a hydrogen atom, an amino group or a hydroxyl group, R is a hydrogen atom, a fluorine atom, an alkyl group, an alkenyl group or an alkynyl group, --COOR.sup.1 and --COOR.sup.2 are independently carboxyl groups which may be esterified and n is an integer of 2 to 4, and R may be different in each of the n repeating units, and salts thereof have excellent antitumor effects, and can be used as antitumor agents in mammals.Type: GrantFiled: December 6, 1993Date of Patent: July 23, 1996Assignee: Takeda Chemical Industries, Ltd.Inventors: Hiroshi Akimoto, Takenori Hitaka, Tetsuo Miwa
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Patent number: 5522126Abstract: A ferrite plate and a ceramic plate are joined to each other by a glass layer interposed therebetween. The ferrite plate and the ceramic plate thus joined to each other by the glass layer serve as a trailing core in the form of a composite for use in a magnetic head. Only the ferrite plate is exposed on a slidable surface to prevent the trailing core from being deformed or cracked. The trailing core has low inductance for high-density recording to prevent the magnetic head from causing recording/reading errors.Type: GrantFiled: March 16, 1994Date of Patent: June 4, 1996Assignee: NGK Insulators, Ltd.Inventors: Tetsuo Miwa, Masatomo Yamauchi, Soichiro Matsuzawa, Nobuhiro Terada
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Patent number: 5496946Abstract: There is provided an improved process for producing novel compounds represented by the general formula: ##STR1## wherein the ring A/ represents a pyrrole ring which may be hydrogenated; X represents an amino, hydroxyl or mercapto group; R.sup.1, R.sup.2 and R.sup.3 each, being the same as or different from the other, represents hydrogen or an alkyl, alkenyl or alkynyl group which may be substituted; R.sup.4 represents OR.sup.5 wherein R.sup.5 represents hydrogen or a hydrocarbon group which may be substituted or NHCH(COOR.sup.6)CH.sub.2 CH.sub.2 COOR.sup.7 wherein R.sup.6 and R.sup.7 each represents hydrogen or a hydrocarbon group which may be substituted; and n represents an integer of 1 to 4, or a salt thereof from compounds represented by the general formula: ##STR2## wherein X, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and n are the same as defined above; Y.sup.1 and Y.sup.2 each represents oxygen or sulfur atom; R.sup.8 and R.sup.Type: GrantFiled: June 9, 1994Date of Patent: March 5, 1996Assignee: Takeda Chemical Industries, Ltd.Inventors: Hiroshi Akimoto, Takenori Hitaka, Tetsuo Miwa
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Patent number: 5459260Abstract: A polycyclic carbapenem compound of the formula (Ia'), (Ib') or (Ic') ##STR1## [wherein COOR.sup.2 is a carboxy group which may be esterified; R.sup.a' is --(CH.sub.2).sub.m --K.sup.a --(CH.sub.2).sub.n --U.sup.a' ; J is O or S; R.sup.b' is --(CH.sub.2).sub.m --K.sup.b --(CH.sub.2).sub.n U.sup.b' ; J' is O, S or CH.sub.2 ; R.sup.c' is --(CH.sub.2).sub.m --K.sup.c --(CH.sub.2).sub.n --U.sup.c', --(CH.sub.2).sub.m --K.sup.d --(CH.sub.2).sub.n --U.sup.d or a pair of groups, one of which is a hydroxy group, with the other being a hydroxzy group or an alkylsulfonylamino group, which may be substituted, in the position ortho to the first-mentioned hydroxy group] or a salt thereof are useful as an antibacterial agent.Type: GrantFiled: September 22, 1993Date of Patent: October 17, 1995Assignee: Takeda Chemical Industries, Ltd.Inventors: Michiyuki Sendai, Tetsuo Miwa
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Patent number: 5393751Abstract: A compound of the formula ##STR1## wherein R.sup.1 is a hydrogen atom or a hydrocarbon group which may be substituted; COOR.sup.2 represents a carboxy group which may be esterified; and ring B is a cyclic group which may be substituted or a pharmaceutically acceptable salt thereof are useful as an antibacterial agent.Type: GrantFiled: October 10, 1990Date of Patent: February 28, 1995Assignee: Takeda Chemical Industries, Ltd.Inventors: Michiyuki Sendai, Tetsuo Miwa
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Patent number: 5349064Abstract: There is provided an improved process for producing novel compounds represented by the general formula: ##STR1## wherein the ring A represents a pyrrole ring which may be hydrogenated; X represents an amino, hydroxyl or mercapto group; R.sup.1, R.sup.2 and R.sup.3 each being the same as or different from the other, represents hydrogen or an alkyl, alkenyl or alkynyl group which may be substituted; R.sup.4 represents OR.sup.5 wherein R.sup.5 represents hydrogen or a hydrocarbon group which may be substituted or NHCH(COOR.sup.6)CH.sub.2 CH.sub.2 COOR.sup.7 wherein R.sup.6 and R.sup.7 each represents hydrogen or a hydrocarbon group which may be substituted; and n represents an integer of 1 to 4, or a salt thereof from compounds represented by the general formula: ##STR2## wherein X, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and n are the same as defined above; Y.sup.1 and Y.sup.2 each represents oxygen or sulfur atom; R.sup.8 and R.sup.Type: GrantFiled: March 8, 1993Date of Patent: September 20, 1994Assignee: Takeda Chemical Industries, Ltd.Inventors: Hiroshi Akimoto, Takenori Hitaka, Tetsuo Miwa
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Patent number: 5296600Abstract: A compound of the formula ##STR1## wherein the ring A pyrrole or pyrroline ring, X is an amino group or a hydroxyl group, Y is a hydrogen atom, an amino group or a hydroxyl group, R is a hydrogen atom, a fluorine atom, an alkyl group, an alkenyl group or an alkynyl group, --COOR.sup.1 and --COOR.sup.2 are independently carboxyl groups which may be esterified and n is an integer of 2 to 4, and R may be different in each of the n repeating units, and salts thereof have excellent antitumor effects, and can be used as antitumor agents in mammals.Type: GrantFiled: January 22, 1992Date of Patent: March 22, 1994Assignee: Takeda Chemical Industries, Ltd.Inventors: Akimoto Hiroshi, Takenori Hitaka, Tetsuo Miwa
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Patent number: 5223620Abstract: New fused pyrimidines of the general formula (I): ##STR1## wherein the ring A is a pyridine ring which may be hydrogenated or a benzene ring which may be hydrogenated, X is an amino group or a hydroxyl group, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently hydrogen, fluorine or a lower alkyl group, and --COOR.sup.5 and --COOR.sup.6 are independently a carboxyl group which may be esterified, and salts thereof have excellent anti-tumor effects, and they can be produced by the following reaction scheme: ##STR2## in which A is, X, R.sup.1 to R.sup.4, --COOR.sup.5 have the above meanings.Type: GrantFiled: February 4, 1992Date of Patent: June 29, 1993Assignee: Takeda Chemical Industries, Ltd.Inventors: Hiroaki Nomura, Hiroshi Akimoto, Tetsuo Miwa
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Patent number: 5106974Abstract: A compound of the formula ##STR1## wherein the ring A is a pyrrole or pyrroline ring, X is an amino group or a hydroxyl group, Y is a hydrogen atom, an amino group or a hydroxyl group, R is a hydrogen atom, a fluorine atom, an alkyl group, an alkenyl group or an alkynyl group, --COOR.sup.1 and --COOR.sup.2 are independently carboxyl groups which may be esterified and n is an integer of 2 to 4, and R may be different in each of the n repeating units, and salts thereof have excellent antitumor effects, and can be used as antitumor agents in mammals.Type: GrantFiled: September 6, 1990Date of Patent: April 21, 1992Assignee: Takeda Chemical Industries, Ltd.Inventors: Hiroshi Akimoto, Takenori Hitaka, Tetsuo Miwa
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Patent number: 4997838Abstract: A compound of the formula ##STR1## wherein the ring .circle.A is a pyrrole or pyrroline ring, X is an amino group or a hydroxyl group, Y is a hydrogen atom, an amino group or a hydroxyl group, R is a hydrogen atom, a fluorine atom, an alkyl group, an alkenyl group or an alkynyl group, --COOR.sup.1 and --COOR.sup.2 are independently carboxyl groups which may be esterified and n is an integer of 2 to 4, and R may be different in each of the n repeating units, and salts thereof have excellent antitumor effects, and can be used as antitumor agents in mammals.Type: GrantFiled: March 21, 1989Date of Patent: March 5, 1991Assignee: Takeda Chemical Industries, Ltd.Inventors: Hiroshi Akimoto, Takenori Hitaka, Tetsuo Miwa
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Patent number: 4946846Abstract: New fused pyrimidines of the general formula (I): ##STR1## wherein the ring .circle. A is a pyridine ring which may be hydrogenated or a benzene ring which may be hydrogenated, X is an amino group or a hydroxyl group, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently hydrogen, fluorine or a lower alkyl group, and --COOR.sup.5 and --COOR.sup.6 are independently a carboxyl group which may be esterified, and salts thereof have excellent anti-tumor effects, and they can be produced by the following reaction scheme: ##STR2## in which .circle. A is, X, R.sup.1 to R.sup.4, --COOR.sup.5 have the above meanings.Type: GrantFiled: March 27, 1989Date of Patent: August 7, 1990Assignee: Takeda Chemical Industries, Ltd.Inventors: Hiroaki Nomura, Hiroshi Akimoto, Tetsuo Miwa