Abstract: Antibodies that specifically bind to CD38, as well as constructs comprising such antibodies fused to attenuated interferon alpha-2B proteins are provided. Anti-CD38-attenuated interferon alpha-2b fusion constructs may be used to inhibit proliferation in cancerous cells that express both CD38 and the receptor for IFN-alpha2b, as well as to induce apoptosis in such cells. Inhibition of proliferation and induction of apoptosis in cancerous cells may serve as the basis for the treatment of the underlying cancer.

Abstract: Antibodies that specifically bind to CD38, as well as constructs comprising such antibodies fused to attenuated interferon alpha-2B proteins are provided. Anti-CD38-attenuated interferon alpha-2b fusion constructs may be used to inhibit proliferation in cancerous cells that express both CD38 and the receptor for IFN-alpha2b, as well as to induce apoptosis in such cells. Inhibition of proliferation and induction of apoptosis in cancerous cells may serve as the basis for the treatment of the underlying cancer.

Abstract: Antibodies that specifically bind to CD38, as well as constructs comprising such antibodies fused to attenuated interferon alpha-2B proteins are provided. Anti-CD38-attenuated interferon alpha-2b fusion constructs may be used to inhibit proliferation in cancerous cells that express both CD38 and the receptor for IFN-alpha2b, as well as to induce apoptosis in such cells. Inhibition of proliferation and induction of apoptosis in cancerous cells may serve as the basis for the treatment of the underlying cancer.

Abstract: Antibodies that specifically bind to CD38, as well as constructs comprising such antibodies fused to attenuated interferon alpha-2B proteins are provided. Anti-CD38-attenuated interferon alpha-2b fusion constructs may be used to inhibit proliferation in cancerous cells that express both CD38 and the receptor for IFN-alpha2b, as well as to induce apoptosis in such cells. Inhibition of proliferation and induction of apoptosis in cancerous cells may serve as the basis for the treatment of the underlying cancer.

Abstract: The present invention relates to new treatments of multidrug resistant disorders, particularly cancers. There is provided a method of treating a cancer including administering an effective amount of a semicarbazone or hydrazone compound to a patient that has cancer, the cancer including a cancerous cell that includes an active efflux mechanism; wherein the compound is a substrate of the active efflux mechanism and the compound is able to form a chelation complex with a metal species in the cancerous cell, the chelation complex being cytotoxic to the cancerous cell.

Abstract: An information medium collecting unit receives and collects information media to be recycled. An inspection unit inspects the information media collected at the information medium collecting unit. An electronic-data recording unit transfers and records electronic data stored in a storage unit onto the information media that are determined to be recyclable as a result of the inspection. A product holding unit holds the information media on which the electronic data is recorded. A product discharging unit discharges the information media held in the product holding unit, in accordance with a distribution request. Since the information media collected at a vending machine are processed inside of the vending machine for recycling and are turned into products inside of the vending machine for direct sale, information media to be discarded are reduced and thus cost to customers to obtain information can be reduced.

Abstract: Information collecting means 9 collects provided information 27 which is added by a user operation to a container 1 storing electronic book data 26 in a storage unit 10 of a host computer 5. Editing means 11 edits the entirety or part of the collected provided information and adds the provided information to the electronic book data. Distribution means 15 adds the edited provided information to the electronic book data published by a publisher 6 and distributes the data.

Abstract: An information-medium collecting unit 2 receives and collects information media to be recycled. An inspection unit 3 inspects the information media collected at the information-medium collecting unit 2. An electronic-data recording unit 5 transfers and records electronic data 15 stored in a storage unit 9 onto the information media that are determined to be recyclable as a result of the inspection. A product holding unit 6 holds the information media on which the electronic data is recorded. A product discharging unit 7 discharges the information media held in the product holding unit 6, in accordance with a distribution request.

Abstract: A leakage inspecting device for a sealing stopper in a mouth portion of a container, including a positioning member including an inner stand wall, the inner stand wall having a diameter larger than a boundary surface between the mouth portion and a brush attached to the mouth portion and configured to make watertight contact with the mouth portion, a first placing unit configured to place the positioning member on the mouth portion at an inspection spot and align axis centers of the positioning member and mouth portion, a second placing unit configured to place the inner stand wall onto an upper surface of the mouth portion and situate the inner stand wall on the mouth portion, an injection unit configured to inject water into the inner stand wall and mouth portion, and a measuring unit including a probe configured to measure electric conductivity of the water.

Abstract: The leakage check system is applied to a vessel having a sealing valve unit that can close a gas passage and a liquid passage of the outlet port of the vessel. To determine the presence of a liquid leakage from the outlet port, there is provided an electrode for measuring liquid electrical conductivity. An actuator moves the electrode forward and backward relative to the outlet port. A forward part of the electrode is surrounded by a liquid receiver cup which is opposed to the outlet port during the leakage check of the liquid in the vessel. The forward part of the electrode is extended from a bottom of the liquid receiving cup. The liquid receiving cup is supplied with a dilution water from a water feeder. The vessel is conveyed by a conveyor with the vessel being upside down so that the outlet port is directed downwardly. The outlet port of the vessel is insertable into the liquid receiving cup.

Abstract: This choke device is characterized in that a starting pump 49 for supplying the fuel in a fuel tank 25 by suction to a starting nozzle port 41, is driven by a fuel motor 53. Starting of the engine is executed by the use of a starting motor or a recoil starter, by supplying the fuel in the fuel tank 25 to the starting nozzle port 41 through sucking of the fuel with the starting fuel pump 49 which is turned by the fuel motor 53, thereby facilitating the ignition by augmenting the concentration of the mixed gas.

Abstract: Disclosed is a fuel supply system for an internal combustion engine having a fuel tank, a combustion chamber defined in an engine cylinder, and an air intake passage communicating with the combustion chamber. The fuel supply system comprises a main fuel passage communicating the fuel tank and the air intake passage, first supply mechanism provided on the main fuel passage for supplying main fuel from the fuel tank to the air intake passage responsive to the cranking of the engine a starting fuel passage defined separate from the main fuel passage and communicating with the air intake passage and the main fuel passage, and second supply mechanism provided on the starting fuel passage for supplying a predetermined amount of starting fuel into the air intake passage, in addition to the supply of main fuel, responsive to the temperature of the engine cylinder upon starting of the engine.

Abstract: This fuel supply is characterized in that a starting pump 49 for supplying the fuel in a fuel tank 25 by suction to a starting nozzle port 41, is driven by a fuel motor 53. Starting of the engine is executed by the use of a starting motor or a recoil starter, by supplying the fuel in the fuel tank 25 to the starting nozzle port 41 through sucking of the fuel with the starting fuel pump 49 which is turned by the fuel motor 53, thereby facilitating the ignition by augmenting the concentration of the mixed gas.