Patents by Inventor Tetsuro Kawanishi
Tetsuro Kawanishi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8822722Abstract: To provide a fluorescent hydrogel having superior detectability of saccharides such as glucose and minimal invasiveness, a method for producing the same, and a sensor for measuring saccharides using the same. A florescent hydrogel having a structure represented by the following chemical formula 1, a method for producing the same, and a sensor for measuring saccharides using the same.Type: GrantFiled: September 7, 2011Date of Patent: September 2, 2014Assignees: Terumo Kabushiki Kaisha, The University of TokyoInventors: Yun-Jung Heo, Hideaki Shibata, Tetsuro Kawanishi, Shoji Takeuchi, Yukiko Matsunaga, Teru Okitsu
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Publication number: 20130267800Abstract: To provide a fluorescent hydrogel having superior detectability of saccharides such as glucose and minimal invasiveness, a method for producing the same, and a sensor for measuring saccharides using the same. A florescent hydrogel having a structure represented by the following chemical formula 1, a method for producing the same, and a sensor for measuring saccharides using the same.Type: ApplicationFiled: September 7, 2011Publication date: October 10, 2013Applicants: THE UNIVERSITY OF TOKYO, TERUMO KABUSHIKI KAISHAInventors: Yun-Jung Heo, Hideaki Shibata, Tetsuro Kawanishi, Shoji Takeuchi, Yukiko Matsunaga, Teru Okitsu
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Patent number: 8101374Abstract: It is an object of the present invention to provide a means for measuring a concentration of various components rapidly with high accuracy and high sensitivity. The present invention is to provide an oxidative chromogenic compound or salt thereof represented by the following chemical formula (1): wherein R1 and R2 are each independently a linear or branched alkyl group having 1 to 5 carbon atoms; R3, R4, R5, R6 and R7 are each independently a hydrogen atom, a carboxyl group or a sulfonic acid group, or salt thereof, provided that at least one of R3 to R7 is a carboxyl group or a sulfonic acid group, or salt thereof, and the others are hydrogen atoms, and the production method thereof, and the reagent composition and test instrument using the same.Type: GrantFiled: March 6, 2008Date of Patent: January 24, 2012Assignee: Terumo Kabushiki KaishaInventors: Tetsuro Kawanishi, Yuzuru Saito, Takako Ariga
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Patent number: 8095196Abstract: A sensor probe for in-situ measurement of pH in a human tissue (e.g., cardiovascular) environment comprises a hollow needle having a tip and a back end. The tip is insertable into the tissue. An optic cable comprises a light conduit surrounded by a cladding. A first end of the light conduit is inserted from the back end of the needle and extends to within a predetermined distance of the tip to define a cavity within the tip. A porous dye layer is contained within the cavity, wherein the dye layer has a response to excitation light delivered through the light conduit that varies according to the pH of the tissue environment. An overcoat layer is deposited on the dye layer, wherein the overcoat layer is ionically permeable and substantially opaque at a light wavelength corresponding to the variable response of the dye layer.Type: GrantFiled: December 19, 2006Date of Patent: January 10, 2012Assignee: Terumo Cardiovascular SystemsInventors: Thomas G. Hacker, Tetsuro Kawanishi
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Patent number: 8083715Abstract: The present invention provides a puncture device and an administration device in which a puncture needle can be stuck certainly to a predetermined region of a skin. The puncture device and the administration device of the present invention are provided with a puncture needle moving means for retaining aforesaid puncture needle to be movable and a skin deforming means for deforming the skin, wherein it is constituted such that the puncture needle is moved by aforesaid puncture needle moving means and punctures the skin deformed by aforesaid skin deforming means.Type: GrantFiled: September 3, 2010Date of Patent: December 27, 2011Assignee: Terumo Kabushiki KaishaInventors: Yutaro Sonoda, Tetsuro Kawanishi, Atsushi Matsumoto
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Patent number: 7873398Abstract: A saccharide-measuring fluorescence sensor substance including a copolymer of at least the following two compounds (I) and (II) is provided: (I) a fluorescent monomer compound represented by the following formula (1): formula (1) wherein: Q, Q? and D3 may be the same or different, may be combined together into a fused ring, and are each a substituent selected from the group consisting of a hydrogen atom, a halogen atom, a hydroxyl group, and substituted or unsubstituted alkyl, acyl, oxyalkyl, carboxyl, carboxylate ester, carboxamido, cyano, nitro, amino and aminoalkyl groups; and D1, D2 and D4 each represent a substituent, wherein at least one of D1, D2 and D4 is a substituent group comprising a vinyl group at an end thereof, and wherein the substituent group comprising a vinyl group at an end thereof enables the fluorescent monomer compound to be soluble in water, and (II) at least one hydrophilic, polymerizable monomer having a vinyl group.Type: GrantFiled: August 12, 2008Date of Patent: January 18, 2011Assignee: Terumo Kabushiki KaishaInventors: Shouji Ochiai, Tetsuro Kawanishi, Atsushi Matsumoto
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Publication number: 20100331875Abstract: The present invention provides a puncture device and an administration device in which a puncture needle can be stuck certainly to a predetermined region of a skin. The puncture device and the administration device of the present invention are provided with a puncture needle moving means for retaining aforesaid puncture needle to be movable and a skin deforming means for deforming the skin, wherein it is constituted such that the puncture needle is moved by aforesaid puncture needle moving means and punctures the skin deformed by aforesaid skin deforming means.Type: ApplicationFiled: September 3, 2010Publication date: December 30, 2010Applicant: TERUMO KABUSHIKI KAISHAInventors: Yutaro SONODA, Tetsuro Kawanishi, Atsushi Matsumoto
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Patent number: 7812155Abstract: A process for preparing an o-alkylated rapamycin derivative represented by the following general formula (1) is provided. The process includes the steps of reacting rapamycin with an alkyl triflate, purifying the resulting reaction product with a normal phase chromatograph and further purifying a purified product, which has been purified with the normal phase chromatograph, with a reverse phase chromatography wherein R represents an alkyl, arylalkyl, hydroxyalkyl, alkoxyalkyl, acyloxyalkyl, aminoalkyl, alkylaminoalkyl, alkoxycarbonylaminoalkyl, acylaminoalkyl, or aryl.Type: GrantFiled: November 26, 2007Date of Patent: October 12, 2010Assignee: Terumo Kabushiki KaishaInventors: Tetsuro Kawanishi, Masashi Isozaki
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Publication number: 20100062464Abstract: It is an object of the present invention to provide a means for measuring a concentration of various components rapidly with high accuracy and high sensitivity. The present invention is to provide an oxidative chromogenic compound or salt thereof represented by the following chemical formula (1): wherein R1 and R2 are each independently a linear or branched alkyl group having 1 to 5 carbon atoms; R3, R4, R5, R6 and R7 are each independently a hydrogen atom, a carboxyl group or a sulfonic acid group, or salt thereof, provided that at least one of R3 to R7 is a carboxyl group or a sulfonic acid group, or salt thereof, and the others are hydrogen atoms, and the production method thereof, and the reagent composition and test instrument using the same.Type: ApplicationFiled: March 6, 2008Publication date: March 11, 2010Applicant: Terumo Kabushiki KaishaInventors: Tetsuro Kawanishi, Yuzuru Saito, Takako Ariga
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Patent number: 7611492Abstract: A puncture device which can stick a puncture needle certainly to a predetermined region of a skin includes a puncture needle having a curvature portion, a retaining member retaining the puncture needle, an indwelling device adapted to be indwelled in a living body by way of the puncture needle, and a guide member mounted at a predetermined position of a body surface. The puncture needle is adapted to be stuck into the skin along the guide member.Type: GrantFiled: November 9, 2006Date of Patent: November 3, 2009Assignee: Terumo Kabushiki KaishaInventors: Yutaro Sonoda, Tetsuro Kawanishi
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Patent number: 7524985Abstract: A fluorescent monomer compound represented by the following formula (1) is provided: wherein Q, Q? and D3 may be the same or different, may be combined together into a fused ring, and are each a substituent selected from the group consisting of a hydrogen atom, a halogen atom, a hydroxyl group, and substituted or unsubstituted alkyl, acyl, oxyalkyl, carboxyl, carboxylate ester, carboxamido, cyano, nitro, amino and aminoalkyl groups; and D1, D2 and D4 each represent a substituent, wherein at least one of D1, D2 and D4 is a substituent group comprising a vinyl group at an end thereof, and wherein the substituent group comprising a vinyl group at an end thereof enables the fluorescent monomer compound to be soluble in water.Type: GrantFiled: August 7, 2007Date of Patent: April 28, 2009Assignee: Terumo Kabushiki KaishaInventors: Shouji Ochiai, Tetsuro Kawanishi, Atsushi Matsumoto
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Publication number: 20080319288Abstract: A saccharide-measuring fluorescence sensor substance including a copolymer of at least the following two compounds (I) and (II) is provided: (I) a fluorescent monomer compound represented by the following formula (1): formula (1) wherein: Q, Q? and D3 may be the same or different, may be combined together into a fused ring, and are each a substituent selected from the group consisting of a hydrogen atom, a halogen atom, a hydroxyl group, and substituted or unsubstituted alkyl, acyl, oxyalkyl, carboxyl, carboxylate ester, carboxamido, cyano, nitro, amino and aminoalkyl groups; and D1, D2 and D4 each represent a substituent, wherein at least one of D1, D2 and D4 is a substituent group comprising a vinyl group at an end thereof, and wherein the substituent group comprising a vinyl group at an end thereof enables the fluorescent monomer compound to be soluble in water, and (II) at least one hydrophilic, polymerizable monomer having a vinyl group.Type: ApplicationFiled: August 12, 2008Publication date: December 25, 2008Applicant: TERUMO KABUSHIKI KAISHAInventors: Shouji Ochiai, Tetsuro Kawanishi, Atsushi Matsumoto
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Patent number: 7450980Abstract: An intracorporeal substance measuring assembly to be provided in an embedded-type substance sensor for detecting and measuring an intercorporeal analyte includes: a detection layer containing at least one fluorescent indicator for generating fluorescence according to the concentration of the analyte; and an optical separation layer which is provided on the detection layer, is optically opaque, permits the analyte to penetrate therethrough, and prevents the penetration therethrough of at least one of living body substances possibly deteriorating the detection layer and/or obstructing the fluorescence.Type: GrantFiled: March 25, 2005Date of Patent: November 11, 2008Assignee: Terumo Kabushiki KaishaInventor: Tetsuro Kawanishi
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Publication number: 20080146796Abstract: A process for preparing an o-alkylated rapamycin derivative represented by the following general formula (1) is provided. The process includes the steps of reacting rapamycin with an alkyl triflate, purifying the resulting reaction product with a normal phase chromatograph and further purifying a purified product, which has been purified with the normal phase chromatograph, with a reverse phase chromatography wherein R represents an alkyl, arylalkyl, hydroxyalkyl, alkoxyalkyl, acyloxyalkyl, aminoalkyl, alkylaminoalkyl, alkoxycarbonylaminoalkyl, acylaminoalkyl, or aryl.Type: ApplicationFiled: November 26, 2007Publication date: June 19, 2008Applicant: Terumo Kabushiki KaishaInventors: Tetsuro Kawanishi, Masashi Isozaki
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Publication number: 20080146902Abstract: A sensor probe for in-situ measurement of pH in a human tissue (e.g., cardiovascular) environment comprises a hollow needle having a tip and a back end. The tip is insertable through tissue into the tissue environment. An optic cable comprises a light conduit surrounded by a cladding. A first end of the light conduit not covered by the cladding is inserted from the back end of the needle and extends to within a predetermined distance of the tip to define a cavity within the tip. A porous dye layer is contained within the cavity adjacent to the first end of the light conduit, wherein the dye layer has a response to excitation light delivered through the light conduit that varies according to the pH of the tissue environment. An overcoat layer is deposited on the dye layer, wherein the overcoat layer is ionically permeable and substantially opaque at a light wavelength corresponding to the variable response of the dye layer.Type: ApplicationFiled: December 19, 2006Publication date: June 19, 2008Inventors: Thomas G. Hacker, Tetsuro Kawanishi
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Patent number: 7388110Abstract: A fluorescent monomer compound represented by the following formula (1) is provided: wherein Q, Q? and D3 may be the same or different, may be combined together into a fused ring, and are each a substituent selected from the group consisting of a hydrogen atom, a halogen atom, a hydroxyl group, and substituted or unsubstituted alkyl, acyl, oxyalkyl, carboxyl, carboxylate ester, carboxamido, cyano, nitro, amino and aminoalkyl groups; and D1, D2 and D4 each represent a substituent, wherein at least one of D1, D2 and D4 is a substituent group comprising a vinyl group at an end thereof, and wherein the substituent group comprising a vinyl group at an end thereof enables the fluorescent monomer compound to be soluble in water.Type: GrantFiled: July 25, 2005Date of Patent: June 17, 2008Assignee: Terumo Kabushiki KaishaInventors: Shouji Ochiai, Tetsuro Kawanishi, Atsushi Matsumoto
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Publication number: 20080021236Abstract: A fluorescent monomer compound represented by the following formula (1) is provided: wherein Q, Q? and D3 may be the same or different, may be combined together into a fused ring, and are each a substituent selected from the group consisting of a hydrogen atom, a halogen atom, a hydroxyl group, and substituted or unsubstituted alkyl, acyl, oxyalkyl, carboxyl, carboxylate ester, carboxamido, cyano, nitro, amino and aminoalkyl groups; and D1, D2 and D4 each represent a substituent, wherein at least one of D1, D2 and D4 is a substituent group comprising a vinyl group at an end thereof, and wherein the substituent group comprising a vinyl group at an end thereof enables the fluorescent monomer compound to be soluble in water.Type: ApplicationFiled: August 7, 2007Publication date: January 24, 2008Applicant: TERUMO KABUSHIKI KAISHAInventors: Shouji Ochiai, Tetsuro Kawanishi, Atsushi Matsumoto
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Publication number: 20080015624Abstract: The present invention provides a puncture device and an administration device in which a puncture needle can be stuck certainly to a predetermined region of a skin. The puncture device and the administration device of the present invention are provided with a puncture needle moving means for retaining aforesaid puncture needle to be movable and a skin deforming means for deforming the skin, wherein it is constituted such that the puncture needle is moved by aforesaid puncture needle moving means and punctures the skin deformed by aforesaid skin deforming means.Type: ApplicationFiled: November 9, 2006Publication date: January 17, 2008Applicant: Terumo Kabushiki KaishaInventors: Yutaro Sonoda, Tetsuro Kawanishi, Atsushi Matsumoto
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Patent number: 7297548Abstract: The present invention provides solid-phase saccharide dyes. The dyes are bisboronic acids covalently bonded to a solid substrate. The dyes selectively conjugate with saccharides, particularly glucose, and register a signal. The signal is proportional to the quantity of saccharide. Thus, the dyes of the present invention are useful for measuring and monitoring saccharide levels, particularly in biological fluids such as blood.Type: GrantFiled: March 28, 2003Date of Patent: November 20, 2007Assignee: Terumo Kabushiki KaishaInventors: Tetsuro Kawanishi, Matthew Albert Romey, Mark Z. Holody, Peter C. Zhu, Seiji Shinkai
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Publication number: 20070167970Abstract: A puncture device which can stick a puncture needle certainly to a predetermined region of a skin includes a puncture needle having a curvature portion, a retaining member retaining the puncture needle, an indwelling device adapted to be indwelled in a living body by way of the puncture needle, and a guide member mounted at a predetermined position of a body surface. The puncture needle is adapted to be stuck into the skin along the guide member.Type: ApplicationFiled: November 9, 2006Publication date: July 19, 2007Applicant: TERUMO KABUSHIKI KAISHAInventors: Yutaro Sonoda, Tetsuro Kawanishi