Patents by Inventor Tetsuro Tabata

Tetsuro Tabata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9901546
    Abstract: An orally disintegrable tablet, of the present invention, which comprises (i) fine granules having an average particle diameter of 400 ?m or less, which fine granules comprise a composition coated by an enteric coating layer, said composition having 10 weight % or more of an acid-labile physiologically active substance and (ii) an additive, has superior disintegrability or dissolution in the oral cavity so that it can be used for treatment or prevention of various diseases, as an orally disintegrable tablet capable of being administered to the aged or children and easily administered without water. Also, because the tablet of the present invention contains fine granules having the average particle diameter such that it will not impart roughness in mouth, it can be administered easily without discomfort at the administration.
    Type: Grant
    Filed: May 27, 2014
    Date of Patent: February 27, 2018
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Toshihiro Shimizu, Shuji Morimoto, Tetsuro Tabata
  • Publication number: 20140271856
    Abstract: An orally disintegrable tablet, of the present invention, which comprises (i) fine granules having an average particle diameter of 400 ?m or less, which fine granules comprise a composition coated by an enteric coating layer, said composition having 10 weight % or more of an acid-labile physiologically active substance and (ii) an additive, has superior disintegrability or dissolution in the oral cavity so that it can be used for treatment or prevention of various diseases, as an orally disintegrable tablet capable of being administered to the aged or children and easily administered without water. Also, because the tablet of the present invention contains fine granules having the average particle diameter such that it will not impart roughness in mouth, it can be administered easily without discomfort at the administration.
    Type: Application
    Filed: May 27, 2014
    Publication date: September 18, 2014
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Toshihiro SHIMIZU, Shuji MORIMOTO, Tetsuro TABATA
  • Patent number: 8486450
    Abstract: It is intended to provide a method of producing a solid preparation disintegrating in the oral cavity characterized by comprising mixing fine subtilaes containing a medicinal ingredient with an additive containing ?-mannitol and tableting the mixture; and a solid preparation disintegrating in the oral cavity produced thereby. This solid preparation disintegrating in the oral cavity has such a strength (hardness) as suffering from no defect even under stresses in transporting, packaging with the use of an automated packaging machine, taking out from a PTP and soon.
    Type: Grant
    Filed: December 27, 2006
    Date of Patent: July 16, 2013
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Shigehiro Higuchi, Hiroshi Fukada, Toshihide Saito, Tetsuro Tabata
  • Publication number: 20110081412
    Abstract: An orally disintegrable tablet, of the present invention, which comprises (i) fine granules having an average particle diameter of 400 ?m or less, which fine granules comprise a composition coated by an enteric coating layer, said composition having 10 weight % or more of an acid-labile physiologically active substance and (ii) an additive, has superior disintegrability or dissolution in the oral cavity so that it can be used for treatment or prevention of various diseases, as an orally disintegrable tablet capable of being administered to the aged or children and easily administered without water. Also, because the tablet of the present invention contains fine granules having the average particle diameter such that it will not impart roughness in mouth, it can be administered easily without discomfort at the administration.
    Type: Application
    Filed: December 14, 2010
    Publication date: April 7, 2011
    Applicant: TAKEDA PHARMACEUTICAL COMPANY, LIMITED
    Inventors: Toshihiro SHIMIZU, Shuji MORIMOTO, Tetsuro TABATA
  • Patent number: 7875292
    Abstract: An orally disintegrable tablet, of the present invention, which comprises (i) fine granules having an average particle diameter of 400 ?m or less, which fine granules comprise a composition coated by an enteric coating layer, said composition having 10 weight % or more of an acid-labile physiologically active substance and (ii) an additive, has superior disintegrability or dissolution in the oral cavity so that it can be used for treatment or prevention of various diseases, as an orally disintegrable tablet capable of being administered to the aged or children and easily administered without water. Also, because the tablet of the present invention contains fine granules having the average particle diameter such that it will not impart roughness in mouth, it can be administered easily without discomfort at the administration.
    Type: Grant
    Filed: May 7, 2008
    Date of Patent: January 25, 2011
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Toshihiro Shimizu, Shuji Morimoto, Tetsuro Tabata
  • Publication number: 20090148524
    Abstract: It is intended to provide a method of producing a solid preparation disintegrating in the oral cavity characterized by comprising mixing fine subtilaes containing a medicinal ingredient with an additive containing ?-mannitol and tableting the mixture; and a solid preparation disintegrating in the oral cavity produced thereby. This solid preparation disintegrating in the oral cavity has such a strength (hardness) as suffering from no defect even under stresses in transporting, packaging with the use of an automated packaging machine, taking out from a PTP and soon.
    Type: Application
    Filed: December 27, 2006
    Publication date: June 11, 2009
    Inventors: Shigehiro Higuchi, Hiroshi Fukada, Toshihide Saito, Tetsuro Tabata
  • Publication number: 20080292701
    Abstract: An orally disintegrable tablet, of the present invention, which comprises (i) fine granules having an average particle diameter of 400 ?m or less, which fine granules comprise a composition coated by an enteric coating layer, said composition having 10 weight % or more of an acid-labile physiologically active substance and (ii) an additive, has superior disintegrability or dissolution in the oral cavity so that it can be used for treatment or prevention of various diseases, as an orally disintegrable tablet capable of being administered to the aged or children and easily administered without water. Also, because the tablet of the present invention contains fine granules having the average particle diameter such that it will not impart roughness in mouth, it can be administered easily without discomfort at the administration.
    Type: Application
    Filed: May 7, 2008
    Publication date: November 27, 2008
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Toshihiro Shimizu, Shuji Morimoto, Tetsuro Tabata
  • Patent number: 7431942
    Abstract: An orally disintegrable tablet of the present invention, which comprises (i) fine granules having an average particle diameter of 400 ?m or less, which fine granules comprise a composition coated by an enteric coating layer, said composition having 10 weight % or more of an acid-labile physiologically active substance and (ii) an additive, has superior disintegrability or dissolution in the oral cavity so that it can be used for treatment or prevention of various diseases, as an orally disintegrable tablet capable of being administered to the aged or children and easily administered without water. Also, because the tablet of the present invention contains fine granules having the average particle diameter such that it will not impart roughness in mouth, it can be administered easily without discomfort at the administration.
    Type: Grant
    Filed: October 30, 2001
    Date of Patent: October 7, 2008
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Toshihiro Shimizu, Shuji Morimoto, Tetsuro Tabata
  • Publication number: 20040209919
    Abstract: The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula 1
    Type: Application
    Filed: April 28, 2004
    Publication date: October 21, 2004
    Applicant: TAKEDA CHEMICAL INDUSTRIES, LTD.
    Inventors: Tadashi Makino, Tetsuro Tabata, Shin-Ichiro Hirai
  • Patent number: 6787082
    Abstract: The punch coated with Cr-Dopé-N is advantageous as a punch for preparing tablets containing an acidic substance or an adhesive substance and is excellent in corrosion resistance and releasing property.
    Type: Grant
    Filed: October 10, 2001
    Date of Patent: September 7, 2004
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Hikaru Fukuyama, Hiroshi Fukada, Tetsuro Tabata, Etsuji Nakamura, Norio Kameoka, Toshihiro Shimizu
  • Patent number: 6749864
    Abstract: The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula wherein R1 is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl, acyl, carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl, R2 is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl, R3 and R5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy, R4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy, and m is an integer of 0 through 4, and a basic inorganic salt stabilizing agent, is physically stable. Magnesium and calcium basic inorganic salt stabilizing agents are particularly useful.
    Type: Grant
    Filed: December 31, 2002
    Date of Patent: June 15, 2004
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Tadashi Makino, Tetsuro Tabata, Shin-Ichiro Hirai
  • Publication number: 20030211155
    Abstract: The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula 1
    Type: Application
    Filed: January 3, 2003
    Publication date: November 13, 2003
    Applicant: TAKEDA CHEMICAL INDUSTRIES, LTD.
    Inventors: Tadashi Makino, Tetsuro Tabata, Shin-Ichiro Hirai
  • Patent number: 6521256
    Abstract: The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula wherein R1 is hydrogen, alkyl, halogen, cyanot carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl, acyl, carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl, R2 is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonyl-methyl, alkoxycarbonylmethyl or alkylsulfonyl, R3 and R5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy, R4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy, and m is an integer of 0 through 4, and a basic inorganic salt stabilizing agent, is physically stable. Magnesium and calcium basic inorganic salt stabilizing agents are particularly useful.
    Type: Grant
    Filed: February 19, 2002
    Date of Patent: February 18, 2003
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Tadashi Makino, Tetsuro Tabata, Shin-Ichiro Hirai
  • Publication number: 20020142034
    Abstract: An orally disintegrable tablet, of the present invention, which comprises (i) fine granules having an average particle diameter of 400 &mgr;m or less, which fine granules comprise a composition coated by an enteric coating layer, said composition having 10 weight % or more of an acid-labile physiologically active substance and (ii) an additive, has superior disintegrability or dissolution in the oral cavity so that it can be used for treatment or prevention of various diseases, as an orally disintegrable tablet capable of being administered to the aged or children and easily administered without water. Also, because the tablet of the present invention contains fine granules having the average particle diameter such that it will not impart roughness in mouth, it can be administered easily without discomfort at the administration.
    Type: Application
    Filed: October 30, 2001
    Publication date: October 3, 2002
    Inventors: Toshihiro Shimizu, Shuji Morimoto, Tetsuro Tabata
  • Publication number: 20020137771
    Abstract: The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula 1
    Type: Application
    Filed: February 19, 2002
    Publication date: September 26, 2002
    Applicant: TAKEDA CHEMICAL INDUSTRIES, LTD.
    Inventors: Tadashi Makino, Tetsuro Tabata, Shin-Ichiro Hirai
  • Patent number: 6380234
    Abstract: The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula wherein R1 is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl, acyl, carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl, R2 is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl, R3 and R5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy, R4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy, and m is an integer of 0 through 4, and a basic inorganic salt stabilizing agent, is physically stable. Magnesium and calcium basic inorganic salt stabilizing agents are particularly useful.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: April 30, 2002
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Tadashi Makino, Tetsuro Tabata, Shin-Ichiro Hirai
  • Publication number: 20020039598
    Abstract: The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula 1
    Type: Application
    Filed: August 8, 2001
    Publication date: April 4, 2002
    Applicant: Takeda Chemical Industries, Ltd.
    Inventors: Tadashi Makino, Tetsuro Tabata, Shin-Ichiro Hirai
  • Patent number: 6328994
    Abstract: An orally disintegrable tablet, of the present invention, which comprises (i) fine granules having an average particle diameter of 400 &mgr;m or less, which fine granules comprise a composition coated by an enteric coating layer, said composition having 10 weight % or more of an acid-labile physiologically active substance and (ii) an additive, has superior disintegrability or dissolution in the oral cavity so that it can be used for treatment or prevention of various diseases, as an orally disintegrable tablet capable of being administered to the aged or children and easily administered without water. Also, because the tablet of the present invention contains fine granules having the average particle diameter such that it will not impart roughness in mouth, it can be administered easily without discomfort at the administration.
    Type: Grant
    Filed: August 4, 1999
    Date of Patent: December 11, 2001
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Toshihiro Shimizu, Shuji Morimoto, Tetsuro Tabata
  • Patent number: 6296875
    Abstract: The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula wherein R1 is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl, acyl, carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl, R2 is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl, R3 and R5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy, R4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy, and m is an integer of 0 through 4, and a basic inorganic salt stabilizing agent, is physically stable. Magnesium and calcium basic inorganic salt stabilizing agents are particularly useful.
    Type: Grant
    Filed: June 7, 2000
    Date of Patent: October 2, 2001
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Tadashi Makino, Tetsuro Tabata, Shin-Ichiro Hirai
  • Patent number: 6123962
    Abstract: The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula ##STR1## wherein R.sup.1 is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl, acyl, carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl, R.sup.2 is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl, R.sup.3 and R.sup.5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy, R.sup.4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy, and m is an integer of 0 through 4, and a basic inorganic salt stabilizing agent, is physically stable. Magnesium and calcium basic inorganic salt stabilizing agents are particularly useful.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: September 26, 2000
    Assignee: Takeda Chemical Industries, Inc.
    Inventors: Tadashi Makino, Tetsuro Tabata, Shin-Ichiro Hirai