Patents by Inventor Tetsushi Katsube
Tetsushi Katsube has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9676720Abstract: The present invention provides a substituted biaryl compound of general formula (I): wherein, R1, W, R2, and Z are as defined in the claims and the description, or a pharmacologically acceptable salt thereof. The compound according to the present invention has an excellent inhibition effect of pulmonary fibroblast proliferation, and is therefore useful as a therapeutic agent and/or a prophylactic agent for interstitial pneumonia and pulmonary fibrosis.Type: GrantFiled: March 28, 2014Date of Patent: June 13, 2017Assignee: UBE INDUSTRIES, LTD.Inventors: Nobuhiko Shibakawa, Kenji Yoneda, Tetsushi Katsube, Tomoko Kanda, Koji Ito, Kiyoshi Yamamoto, Noriaki Iwase, Shigeru Ushiyama
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Publication number: 20160213657Abstract: Provided is a pharmaceutical composition containing, as an active ingredient thereof, a substituted biaryl compound represented by general formula (I), wherein, R1, W, R2 and Z are as defined in the claims and description, or a pharmacologically acceptable salt thereof. The pharmaceutical composition of the present invention is useful as a therapeutic drug and/or prophylactic drug for chronic obstructive pulmonary disease due to having an excellent anti-inflammatory effect.Type: ApplicationFiled: September 2, 2014Publication date: July 28, 2016Applicant: UBE INDUSTRIES, LTD.Inventors: Kenji YONEDA, Nobuhiko SHIBAKAWA, Tetsushi KATSUBE, Tomoko KANDA, Koji ITO, Kiyoshi YAMAMOTO, Masaru SHINOHARA, Noriaki IWASE, Shigeru USHIYAMA
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Publication number: 20160060221Abstract: The present invention provides a substituted biaryl compound of general formula (I): wherein, R1, W, R2, and Z are as defined in the claims and the description, or a pharmacologically acceptable salt thereof. The compound according to the present invention has an excellent inhibition effect of pulmonary fibroblast proliferation, and is therefore useful as a therapeutic agent and/or a prophylactic agent for interstitial pneumonia and pulmonary fibrosis.Type: ApplicationFiled: March 28, 2014Publication date: March 3, 2016Applicant: UBE INDUSTRIES, LTD.Inventors: Nobuhiko SHIBAKAWA, Kenji YONEDA, Tetsushi KATSUBE, Tomoko KANDA, Koji ITO, Kiyoshi YAMAMOTO, Noriaki IWASE, Shigeru USHIYAMA
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Publication number: 20140113907Abstract: The present invention provides a pyridylaminoacetic acid compound represented by the following formula (1): (wherein R1, R2, R3, Y and Z are as defined in the description and claims), or a pharmacologically acceptable salt thereof. Since the pyridylaminoacetic acid compound has EP2 agonistic action, it is useful as a therapeutic or prophylactic drug for respiratory diseases such as asthma or chronic obstructive pulmonary disease.Type: ApplicationFiled: December 16, 2013Publication date: April 24, 2014Applicant: UBE INDUSTRIES, LTD.Inventors: Ryo IWAMURA, Masayuki TANAKA, Tetsushi KATSUBE, Manabu SHIGETOMI, Eiji OKANARI, Yasunori TOKUNAGA, Hiroshi FUJIWARA
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Patent number: 8648097Abstract: The present invention provides a novel pyridylaminoacetic acid compound represented by the following formula (1): (wherein R1, R2, R3, Y and Z are as defined in the description and claims), or a pharmacologically acceptable salt thereof. The pyridylaminoacetic acid compound has EP2 agonistic action and is therefore useful as a therapeutic and/or prophylactic agent for respiratory diseases such as asthma or chronic obstructive pulmonary disease.Type: GrantFiled: March 12, 2009Date of Patent: February 11, 2014Assignee: Ube Industries, Ltd.Inventors: Ryo Iwamura, Masayuki Tanaka, Tetsushi Katsube, Manabu Shigetomi, Eiji Okanari, Yasunori Tokunaga, Hiroshi Fujiwara
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Patent number: 8450319Abstract: The present invention discloses a pyrrolopyridazinone compound represented by the formula (1): useful, for example, as an anti-inflammatory agent or an inhibitor of respiratory tract contraction.Type: GrantFiled: January 16, 2007Date of Patent: May 28, 2013Assignee: Ube Industries, Ltd.Inventors: Masahiko Hagihara, Masayuki Tanaka, Tetsushi Katsube, Makoto Okudo, Noriaki Iwase, Manabu Shigetomi, Tomoko Kanda, Takayuki Nakanishi
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Publication number: 20120259123Abstract: The present invention relates to a compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, a medical composition containing the same, and a medical composition for the treatment or prophylaxis of respiratory diseases or glaucoma.Type: ApplicationFiled: December 24, 2010Publication date: October 11, 2012Applicant: UBE INDUSTRIES, LTD.Inventors: Ryo Iwamura, Masayuki Tanaka, Tetsushi Katsube, Nobuhiko Shibakawa, Manabu Shigetomi, Eiji Okanari, Tomoko Kanda, Yasunori Tokunaga, Hiroshi Fujiwara
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Publication number: 20110054172Abstract: The present invention provides a novel pyridylaminoacetic acid compound represented by the following formula (1): (wherein R1, R2, R3, Y and Z are as defined in the description and claims), or a pharmacologically acceptable salt thereof. The pyridylaminoacetic acid compound has EP2 agonistic action and is therefore useful as a therapeutic and/or prophylactic agent for respiratory diseases such as asthma or chronic obstructive pulmonary disease.Type: ApplicationFiled: March 12, 2009Publication date: March 3, 2011Inventors: Ryo Iwamura, Masayuki Tanaka, Tetsushi Katsube, Manabu Shigetomi, Eiji Okanari, Yasunori Tokunaga, Hiroshi Fujiwara
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Publication number: 20090036453Abstract: The present invention discloses a pyrrolopyridazinone compound represented by the formula (1): wherein R1 represents C1-C2 alkyl group or halogeno C1-C2 alkyl group, R2 repersents C3-C5 cycloalkyl group, (C3-C5 cycloalkyl)C1-C2 alkyl group or C1-C3 alkyl group, R3 represents hydrogen atom, or methylene group or cis-vinylene group for forming substituted oxygen-containing hetero ring in combination with group —O—R2, R4 represents hydrogen atom, halogen atom, C1-C8 alkyl group, C2-C6 alkenyl group, C2-C6 alkynyl group, hydroxy C3-C6 alkenyl group, hydroxy C3-C6 alkynyl group, C1-C6 alkyl group substituted by substituent(s) selected from Substituent group (a), C3-C6 cycloalkyl group which may be substituted by substituent(s) selected from Substituent group (b), “C1-C3 alkyl group which is substituted by C3-C6 cycloalkyl group which may be substituted by substituent(s) selected from Substituent group (b), and which may be substituted by a hydroxy group”, an aromatic ring group or heteroaromatic ring group eType: ApplicationFiled: January 16, 2007Publication date: February 5, 2009Inventors: Masahiko Hagihara, Masayuki Tanaka, Tetsushi Katsube, Makoto Okudo, Noriaki Iwase, Manabu Shigetomi, Tomoko Kanda, Takayuki Nakanishi
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Patent number: 7309718Abstract: The present invention discloses a dibenzocycloheptene compound represented by the formula (I): wherein R1: hydrogen atom, halogen atom, etc., R2: hydrogen atom, halogen atom, etc., A: 5-membered or 6-membered heteroaromatic ring group containing 1 to 3 hetero atom(s) selected from the group consisting of nitrogen atom, oxygen atom and sulfur atom, and the heteroaromatic ring group, etc. may have halogen atom, nitrogen atom, etc. as substituent(s), B: formula; —CH?CH—, formula; —CH2O—, etc., Y: C1-C10 alkylene group which may have halogen atom, etc. as substituent(s), etc., Z: carboxyl group which may be protected, etc.Type: GrantFiled: June 27, 2002Date of Patent: December 18, 2007Assignee: UBE Industries, Ltd.Inventors: Yoshiaki Kuroki, Hitoshi Ueno, Tetsushi Katsube, Tetsuo Kawaguchi, Eiji Okanari, Ichiro Tanaka, Masayuki Tanaka, Masahiko Hagihara
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Publication number: 20040180884Abstract: The present invention discloses a dibenzocycloheptene compound represented by the formula (I): 1Type: ApplicationFiled: December 23, 2003Publication date: September 16, 2004Inventors: Yoshiaki Kuroki, Hitoshi Ueno, Tetsushi Katsube, Tetsuo Kawaguchi, Eiji Okanari, Ichiro Tanaka, Masayuki Tanaka, Masahiko Hagihara
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Publication number: 20030216571Abstract: The present invention is to provide novel tricyclic compounds having leukotriene antagonistic action and represented by the formula: 1Type: ApplicationFiled: July 31, 2002Publication date: November 20, 2003Inventors: Yoshiaki Kuroki, Hitoshi Ueno, Tetsushi Katsube, Tetsuo Kawaguchi, Eiji Okanari, Takashi Ikuta
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Patent number: 6034086Abstract: This invention relates to a 8-trifluoromethylquinolinecaboxylic acid derivative represented by the following formula (I): ##STR1## (wherein R.sup.1 represents a lower alkyl group, a halogeno-lower alkyl group or a cycloalkyl group, R.sup.2 represents a phenyl group which may be substituted by R.sup.0, a 5-membered or 6-membered aromatic heteromonocyclic ring group containing 1 or 2 hetero atoms selected from N, O and S, which may be substituted by R.sup.0, or an aromatic heterocyclic fused ring group in which the said aromatic heteromonocyclic ring group and a benzene ring are fused, R.sup.0 represents a group selected from a halogen, a lower alkyl, a fluorine-substituted lower alkyl, a lower alkoxy or a lower alkylthio, R.sup.3 represents hydrogen or a lower alkyl group, and m represents an integer of 2 or 3.) or a pharmaceutically acceptable salt thereof or an ester thereof.Type: GrantFiled: September 16, 1998Date of Patent: March 7, 2000Assignees: Ube Industries, Ltd., Sankyo Company, LimitedInventors: Tomio Kimura, Tetsushi Katsube, Takashi Nishigaki
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Patent number: 5688791Abstract: Disclosed are an aryl group- or heterocyclic group-substituted aminoquinolone compound represented by the formula (Ia), (Ib) or (Ic): ##STR1## wherein each of the substitutents are defined in the specification, or a salt of the compound, and an AIDS curing agent containing the same as an effective ingredient.Type: GrantFiled: September 11, 1995Date of Patent: November 18, 1997Assignee: UBE Industries, LTD.Inventors: Tomio Kimura, Tetsushi Katsube
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Aryl group- or aromatic heterocyclic group-substituted aminoquinolone derivatives and anti-HIV agent
Patent number: 5519016Abstract: Disclosed are an aryl group- or heterocyclic group-substituted aminoquinolone compound represented by the formula (Ia), (Ib) or (Ic): ##STR1## wherein each of the substitutents are defined in the specification, or a salt of the compound, and an AIDS curing agent containing the same as an effective ingredient.Type: GrantFiled: November 15, 1994Date of Patent: May 21, 1996Assignee: Ube Industries, Ltd.Inventors: Tomio Kimura, Tetsushi Katsube -
Patent number: 5496951Abstract: Compounds of formula (I): ##STR1## (in which: R.sup.1 represents fluorinated methoxy: R.sup.2 represents a nitrogen-containing heterocyclic group and R.sup.3 represents hydrogen or amino) and pharmaceutically acceptable salts, esters and amides thereof are valuable antibacterial agents, which may be prepared by reacting a compound similar to that of formula (I) but in which R.sup.2 is replaced by a halogen atom with a compound providing the required group R.sup.2.Type: GrantFiled: January 27, 1995Date of Patent: March 5, 1996Assignees: Sankyo Company, Limited, Ube Industries LimitedInventors: Masayuki Iwata, Tomio Kimura, Teruhiko Inoue, Yoshimi Fujihara, Tetsushi Katsube
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Patent number: 5436367Abstract: Compounds of formula (I): ##STR1## (in which: R.sup.1 represents fluorinated methoxy; R.sup.2 represents a nitrogen-containing heterocyclic group and R.sup.3 represents hydrogen or amino) and pharmaceutically acceptable salts, esters and amides thereof are valuable antibacterial agents, which may be prepared by reacting a compound similar to that of formula (I) but in which R.sup.2 is replaced by a halogen atom with a compound providing the required group R.sup.2.Type: GrantFiled: April 14, 1994Date of Patent: July 25, 1995Assignees: Sanko Company, Limited, UBE Industries LimitedInventors: Masayuki Iwata, Tomio Kimura, Teruhiko Inoue, Yoshimi Fujihara, Tetsushi Katsube
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Patent number: 5348961Abstract: Compounds of formula (I): ##STR1## (in which: R.sup.1 represents fluorinated methoxy; R.sup.2 represents a nitrogen-containing heterocyclic group and R.sup.3 represents hydrogen or amino) and pharmaceutically acceptable salts, esters and amides thereof are valuable antibacterial agents, which may be prepared by reacting a compound similar to that of formula (I) but in which R.sup.2 is replaced by a halogen atom with a compound providing the required group R.sup.2.Type: GrantFiled: October 9, 1990Date of Patent: September 20, 1994Assignee: Sankyo Company LimitedInventors: Masayuki Iwata, Tomio Kimura, Teruhiko Inoue, Yoshimi Fujihara, Tetsushi Katsube
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Patent number: 5073556Abstract: Compounds of formula (I): ##STR1## (in which: R.sup.1 represents fluorinated methoxy; R.sup.2 represents a nitrogen-containing heterocyclic group and R.sup.3 represents hydrogen or amino) and pharmaceutically acceptable salts, esters and amides thereof are valuable antibacterial agents, which may be prepared by reacting a compound similar to that of formula (I) but in which R.sup.2 is replaced by a halogen atom with a compound providing the required group R.sup.2.Type: GrantFiled: February 22, 1991Date of Patent: December 17, 1991Assignees: Sankyo Company Limited, Ube Industries LimitedInventors: Masayuki Iwata, Tomio Kimura, Teruhiko Inoue, Yoshimi Fujihara, Tetsushi Katsube
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Patent number: 4997943Abstract: Compounds of formula (I): ##STR1## (in which R.sup.1 is alkoxy, R is alkyl, haloalkyl, alkylamino, cycloalkyl or optionally substituted phenyl, X is chlorine or fluorine and Y is selected from certain specific heterocycles) have excellent antibacterial activity. They may be prepared by introducing the group represented by Y into the corresponding compound in which Y is replaced by a halogen atom.Type: GrantFiled: March 31, 1987Date of Patent: March 5, 1991Assignees: Sankyo Company Limited, Ube Industries LimitedInventors: Masayuki Iwata, Tomio Kimura, Yoshimi Fujihara, Tetsushi Katsube