Patents by Inventor Tetsushi Totani

Tetsushi Totani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Platinum complexes and antitumor agents containing them as an active ingredient
    Patent number: 4968826
    Abstract: Novel platinum complexes of the formula: ##STR1## wherein R.sup.1 and R.sup.2 each identically of differently is lower alkyl, or R.sup.1 and R.sup.2 taken together form --(CH.sub.2)m--, and m is an integer from 2 to 5, and antitumor agents comprising the compound (I), which are effective against cisplatin-resistant ascitic murine leukemia, murine leukemia, and solid tumor, with slight hemotoxicity and nephrotoxicity.
    Type: Grant
    Filed: March 16, 1990
    Date of Patent: November 6, 1990
    Assignee: Shionogi & Co., Ltd.
    Inventors: Tetsushi Totani, Osamu Shiratori, Yoshihiro Muraoka
  • Ammine-alicyclic amine-platinum complexes and antitumor agents
    Patent number: 4902797
    Abstract: A compound of the formula (I): ##STR1## (wherein R is C.sub.1 -C.sub.6 alkyl, hydroxy, carboxy, C.sub.1 -C.sub.6 alkoxy, halogen or oxo; m is an integer from 2 to 7; X and Y each is chlorine or nit-rato ligand, or taken together form --OCOCH(R.sup.1)O--, OCOCOO--, ##STR2## R.sup.1 is hydrogen, C.sub.1 -C.sub.5 alkyl, hydroxymethyl, halogmethyl or phenyl; R.sup.2 is hydrogen or C.sub.1 -C.sub.5 alkyl; and n is an integer from 2 to 5), being useful as antitumor agents is provided.
    Type: Grant
    Filed: December 18, 1987
    Date of Patent: February 20, 1990
    Assignee: Shionogi & Co., Ltd.
    Inventors: Tetsushi Totani, Katsutoshi Aono, Yasuko Adachi
  • Platinum complexes
    Patent number: 4658048
    Abstract: Novel platinum (IV) complexes having potent antitumor and antibacterial activities and high water solubility with low toxicity and pharmaceutical and/or veterinarily compositions containing one or more compounds together with one or more carriers are provided.They can be prepared by reacting a corresponding platinum (II) complex with hydrogen peroxide or halogen.
    Type: Grant
    Filed: June 6, 1985
    Date of Patent: April 14, 1987
    Assignee: Shionogi & Co., Ltd.
    Inventors: Tetsushi Totani, Osamu Shiratori, Katsutoshi Aono, Naomi Uchida
  • Glycolic acid type platinum complexes
    Patent number: 4577038
    Abstract: Novel platinum complexes of glycolic acid type having potent antitumor activity and high water solubility with low nephrotoxicity and a pharmaceutical composition containing one or more said compounds together with one or more carriers, diluents or excipients are provided. They can be administered parenterally to patients suffering from malignant tumors.They are prepared by passing nitrato-platinum complexes of amines through anion exchange resins and subsequent reaction with glycolic acids.
    Type: Grant
    Filed: May 4, 1984
    Date of Patent: March 18, 1986
    Assignee: Shionogi & Co., Ltd.
    Inventors: Tetsushi Totani, Katsutoshi Aono
  • Platinum complexes
    Patent number: 4575550
    Abstract: Platinum complexes of the following formula useful as antitumor agents with less nephro-toxicity and higher water solubility than cisplatin: ##STR1## wherein X and Y respectively or taken together represent a mono- or di-valent residue of hydroxycarboxylic acids.
    Type: Grant
    Filed: April 14, 1983
    Date of Patent: March 11, 1986
    Assignee: Shionogi & Co., Ltd.
    Inventor: Tetsushi Totani
  • Glycolic acid platinum complexes
    Patent number: 4560781
    Abstract: Novel water-soluble glycolic acid platinum complexes which have more potent antitumor activity with lower nephrotoxicity than cisplatin are provided.They can be administered parenterally to mice attacked by malignant tumors.Prepared from dinitrato-platinum complexes of amines on treatment with anion exchange resins and subsequent reaction with glycolic acid.
    Type: Grant
    Filed: November 17, 1983
    Date of Patent: December 24, 1985
    Assignee: Shionogi & Co., Ltd.
    Inventors: Tetsushi Totani, Katsutoshi Aono, Michihiro Komura
  • Organo-platinum complex
    Patent number: 4359425
    Abstract: Organo-platinum complexes of the following formula having excellent antitumor actions: ##STR1## X and Y each or taken together is a mono- or bi-functional ligand selected from the group consisting of halogeno, nitrato, sulfonato, monocarboxylato (mono-functional), sulfato, and dicarboxylato (bi-functional);and each of n and m is an integer of 1 or 2.
    Type: Grant
    Filed: March 31, 1981
    Date of Patent: November 16, 1982
    Assignee: Shionogi & Co., Ltd.
    Inventors: Tetsushi Totani, Kenji Yamaguchi