Abstract: The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Q, R1, X1, X2, Y and R2 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

Abstract: A magnetic resonance imaging apparatus according to an embodiment includes a gradient coil configured to generate a gradient magnetic field in an image taking space. The gradient coil includes: a first coil member formed by using a first metal that is non-magnetic; and a second coil member connected to the first coil member and formed by using a second metal that is different from the first metal and is non-magnetic.

Abstract: The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein R1, R2, R3, R4, and R5 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

Abstract: Compounds of Formula I are disclosed, As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.

Abstract: In a reconstruction processing (S1), reconstruction processing is performed to list mode data to firstly capture a reconstruction image. Then, in a projection step (S2), the reconstruction image obtained in the reconstruction processing step is projected to capture a projection image. In a scatter component extracting step S4, low-frequency components are extracted from the projection image obtained in the projection step to obtain scatter components. Even when the data contains a missing region, the reconstruction processing unlikely to be influenced by the missing region suppresses the influence by the missing, and the resultant reconstruction image is projected. Consequently, the projection image having dummy data being interpolated to the missing region is obtainable. As a result, projection from the list mode data through the reconstruction image achieves the projection image with no missing data. Accordingly, precious estimation of the scatter components is obtainable.

Abstract: The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein R1, R2, R3, R4, and R5 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

Abstract: The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein W1, W2, W3, R1, Q, X1, X2 and X3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

Abstract: An information processing device including a plurality of rectangular-shaped casings each including a first principal surface, and a second principal surface opposing the first principal surface and including a display panel having a predetermined aspect ratio. The information processing device including a connecting portion connecting each of the plurality of rectangular-shaped casings in a closed state in which each of the plurality of rectangular-shaped casings are mutually overlaid and a display panel of at least one of the plurality of rectangular-shaped casings is externally exposed, and in an open state in which wall portions of mutually adjacent rectangular-shaped casings abut and the display panels of each of the plurality of rectangular-shaped casings face a similar direction. The information processing device further includes a terminal state detecting unit that detects the closed state and the opened state, and a display control unit that controls display of each of the display panels.

Abstract: This application relates to chemical compounds which may act as inhibitors of; or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2, R2b, R3, R4a, R4b, and R5 are described herein.

Abstract: A terminal apparatus includes an acceptance unit, a memory, a display, and a transmitter. The acceptance unit accepts an operation. The memory stores a reading condition for executing a reading process. The display displays multiple icons for an individual reading condition, the multiple icons representing the individual reading condition. In a case where the acceptance unit accepts an operation for selecting one of the multiple icons, the transmitter transmits instruction data for instructing that a reading process be performed under the reading condition corresponding to the selected icon to an external reading apparatus which is to execute the reading process.

Abstract: An information processing system includes a terminal apparatus an information processing apparatus. The terminal apparatus includes a first language information memory; a first display displaying a processing parameter option used in information processing in a first language; a first acceptance unit accepting a first instruction; a first generation unit generating first instruction data; an instruction data transmission unit; a notification data reception unit receiving notification data; and a first notification unit.

Abstract: An apparatus is provided, which monitors an operation state of a battery composed of a plurality of cells mutually connected in series. In this apparatus, a cell voltage of each of the plurality of cells is detected as information indicating an operation state of the battery. Based on the detected cell voltages, an operation state is monitored for a cell having a highest cell voltage and a cell having a lowest cell voltage among the plurality of cells.

Abstract: The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein W1, W2, W3, R1, Q, X1, X2 and X3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, and X are described herein.

Abstract: A cartridge-type optical functional module can achieve excellent optical coupling and has an optical fiber-type module or a waveguide-type module. The present invention relates to a cartridge-type optical functional module which has: first and second optical fiber collimators; an optical functional object which has an optical fiber-type module or a waveguide-type module; and a base section. The optical functional object has a third collimator, and a first alignment mechanism for aligning the position of the third collimator in the optical functional object.

Abstract: The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein W1, W2, W3, R1, Q, X1, X2 and X3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

Abstract: The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein R1, R2, R3, R4, and R5 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

Abstract: A trigger-type liquid sprayer of the present invention is provided with a liquid sprayer body 2 having a nozzle 21 and a trigger lever 22 and a shroud 3 covering the liquid sprayer body 2 and sprays a liquid from a spray hole 211 in the nozzle 21 by a pulling operation of the trigger lever 22. The nozzle 21 is rotatable with respect to the liquid sprayer body 2 and provided so as to open/close a flow passage for the liquid according to a rotational position of the nozzle 21 when an operation lever 24 mounted on the nozzle 21 is rotationally moved, and an abutment portion 31 for positioning the nozzle 21 at a position where the flow passage is opened through abutment of the operation lever 24 is provided at the shroud 3.

Abstract: A method of non-destructive inspection of a subject body including one or more elements comprises irradiating the subject body with a neutron ray along an axis line passing through a reference point; synchronously detecting gamma rays from directions inclined at equal angles to the axis line at a plurality of measurement points disposed to have equivalent intervals radially from the axis line, respectively; measuring the detected gamma rays in a plurality of energy ranges; determining whether measured values in the respective energy ranges are beyond thresholds; determining energy ranges where all the measured values are beyond the thresholds; analyzing a type of an element from the determined energy ranges; and detecting a location of the analyzed type of the element in the subject body on the basis of the reference point, the respective measurement points, a relative position relative to a surface of the subject body, and the directions.

Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.