Abstract: In an embodiment, an object of the present invention is to provide a double-stranded nucleic acid complex having a novel structure. In an embodiment, the present invention relates to a nucleic acid complex comprising a first nucleic acid strand and a second nucleic acid strand, wherein said first nucleic acid strand: (1) is capable of hybridizing to at least a part of a target transcriptional product; (2) has an antisense effect on the target transcriptional product; and (3) is a gapmer comprising a central region, and a 5? wing region and a 3? wing region, said second nucleic acid strand comprises at least one sugar-unmodified central region (first exposed region) consisting of one sugar-unmodified ribonucleoside or two or three contiguous sugar-unmodified ribonucleosides linked by an internucleoside bond, which is or are complementary to a part of said first nucleic acid strand, and said first nucleic acid strand is annealed to said second nucleic acid strand.

Abstract: There is provided a stirring device including a stirring tank including an inner peripheral wall which is circular in cross section, at least one circulating impeller and at least one dispersion blade which are located inside the stirring tank and rotatable around a vertical axis independently of each other, and a guide ring disposed radially outward near the dispersion blade. The circulating impeller is disposed along the inner peripheral wall of the stirring tank, and rotates around the vertical axis to form at least a downward flow in a stirring object existing inside the stirring tank. The dispersion blade rotates to apply a shear force to the stirring object, and is disposed at a radially inner position of the stirring tank from the circulating impeller, and at a position in contact with a flow of the stirring object, which is formed by the circulating impeller.

Abstract: There is provided a stirring device including a stirring tank including an inner peripheral wall which is circular in cross section, at least one circulating impeller and at least one dispersion blade which are located inside the stirring tank and rotatable around a vertical axis independently of each other, and a guide ring disposed radially outward near the dispersion blade. The circulating impeller is disposed along the inner peripheral wall of the stirring tank, and rotates around the vertical axis to form at least a downward flow in a stirring object existing inside the stirring tank. The dispersion blade rotates to apply a shear force to the stirring object, and is disposed at a radially inner position of the stirring tank from the circulating impeller, and at a position in contact with a flow of the stirring object, which is formed by the circulating impeller.

Abstract: Provided is a stirring device including: a stirred tank, of which an inner peripheral wall has a circular shape in cross section; and at least one flow impeller and at least one shearing impeller that are located inside the stirred tank and configured to be rotatable independently of each other, in which rotational centers of the flow impeller and the shearing impeller are coaxially provided, the flow impeller rotates around a vertical axis along the inner peripheral wall of the stirred tank to form at least a flow directed toward a lower side in the stirring object existing in the stirred tank, and the shearing impeller imparts a shearing force to the stirring object and is provided on a radially inward side of the flow impeller in the stirred tank and at a position contacting the flow of the stirring object formed by the flow impeller.

Abstract: Provided is a stirring device including: a stirred tank, of which an inner peripheral wall has a circular shape in cross section; and at least one flow impeller and at least one shearing impeller that are located inside the stirred tank and configured to be rotatable independently of each other, in which rotational centers of the flow impeller and the shearing impeller are coaxially provided, the flow impeller rotates around a vertical axis along the inner peripheral wall of the stirred tank to form at least a flow directed toward a lower side in the stirring object existing in the stirred tank, and the shearing impeller imparts a shearing force to the stirring object and is provided on a radially inward side of the flow impeller in the stirred tank and at a position contacting the flow of the stirring object formed by the flow impeller.

Abstract: Provided are a tube type heat exchanger and a method of the tube type heat exchanger capable of preventing spiral fins 12 from being deformed. In the tube type heat exchanger and the manufacturing method of the same according to the present invention, the plural spiral fins 12 are disposed in series in the axial direction so as to have edges of the spiral fins 12, 12 spaced apart from each other, and each holder 3 is disposed between the spiral fins 12, 12 and abuts to the outer circumference of the tube body 11.