Abstract: 3-Indolecarboxamide compounds of the formula: ##STR1## inclusive of pharmaceutically acceptable acid addition salt and/or hydrate forms thereof, wherein R.sup.1 is hydrogen or C.sub.1-4 alkyl; each of R.sup.2 and R.sup.3 is hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, benzyloxy, C.sub.2-6 alkanoyloxy or hydroxy; R.sup.4 is hydrogen or C.sub.1-4 alkyl; R.sup.5 is hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or hydroxy; R.sup.6 is hydrogen or C.sub.1-4 alkyl; X is oxygen, sulfur or direct bond; each of k and m is an integer of 1 to 3; and n is 1 or 2, are useful as drug for the prevention and treatment of various circulatory diseases.

Abstract: Indeno[1,2-b]pyrrole derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, lower alkyl or carbamoylmethyl, R.sup.2 is halogen or trifluoromethyl, R.sup.3 is hydrogen or halogen, and X is oxygen or sulfur. These compounds are useful as medicines such as drugs for treating cerebral dysfunction, anticonvulsants, antiepileptics and antianxiety drugs.

Abstract: 3-Indolecarboxamide compounds of the formula: ##STR1## inclusive of pharmaceutically acceptable acid addition salt and/or hydrate forms thereof, wherein R.sup.1 is C.sub.1-8 alkyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cycloalkyl-C.sub.1-8 alkyl, allyl, propargyl, or phenyl or phenyl-C.sub.1-4 alkyl which may be optionally substituted, on the benzene ring, by at least one substituent selected from the group consisting of halogen, trifluoromethyl, C.sub.1-4 alkyl and C.sub.1-4 alkoxy; R.sup.2 is H or C.sub.1-6 alkyl; R.sup.3 is H, halogen, C.sub.2-6 alkanoyloxy, benzoyloxy, C.sub.1-4 alkoxy, benzyloxy, hydroxy or C.sub.1-4 alkyl; R.sup.4 is H, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or hydroxy; R.sup.5 is H or C.sub.1-4 alkoxy; A is ethylene or trimethylene, which may be optionally substituted by C.sub.1-4 alkyl; n is zero, 1 or 2; and m is zero or 1, are useful as drugs for the prevention and treatment of various allergic diseases.

Abstract: 1,4-Methano-2,3,4,5-tetrahydro-1H-2-benzazepin-3-one derivatives of the formula: ##STR1## wherein X is halogen, n is 1 or 2, and R is hydrogen, lower alkyl or phenyl-lower alkyl. They are useful as medicaments, e.g. cerebral dysfunction-improving drugs, anti-convulsants, anti-epileptics and anti-anxiety drugs.

Abstract: Benzo[f]quinoline derivatives which are useful as antihypertensive agents and are represented by the formula: ##STR1## wherein R.sup.1 is hydrogen or lower alkyl, R.sup.2 is hydrogen, lower alkyl, hydroxy-lower-alkyl or lower-alkoxy-lower-alkyl, R.sup.3 and R.sup.4 are the same or different and each is hydrogen, lower alkyl, halogen, lower alkoxy, benzyloxy or hydroxy, R.sup.5 and R.sup.6 are the same or different and each is hydrogen, straight or branched alkyl, aralkyl or cycloalkyl, or R.sup.5 and R.sup.6 together with the adjacent nitrogen atom form a heterocycle, and the dotted line in the ring is an optional bond between 1- and 2-positions, and pharmaceutically acceptable acid addition salts thereof.

Abstract: There are disclosed tetrahydrofuran compounds and analogs thereof of the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein X is oxygen or sulfur, R.sup.1 and R.sup.2 are each hydrogen, halogen, lower alkyl or lower alkoxy, and Am is a group of the formula: ##STR2## wherein Z is oxygen or sulfur, R.sup.3 is hydrogen or halogen, R.sup.4 is hydrogen, lower alkyl or phenyl which may be substituted by 1 to 3 substituents at any position(s) on the phenyl nucleus, each substituent being independently selected from halogen, lower alkyl and lower alkoxy, and R.sup.5 is hydrogen or lower alkyl. Such compounds are useful as neuroleptics.

Abstract: Thienodiazepines of the formula: ##STR1## wherein Ar is mono- or di-substituted phenyl [the substituents(s) being H, halogen, C.sub.1.sub.-4 alkyl or C.sub.1.sub.-4 alkoxy] or pyridyl; R.sup.1 is H or C.sub.1.sub.-4 alkyl; R.sup.2 is H, halogen or C.sub.1.sub.-4 alkyl; or R.sup.1 and R.sup.2 combinedly form -(CH.sub.2).sub.4 -; each of R.sup.3 and R.sup.4 is C.sub.1.sub.-4 alkyl, or R.sup.3 and R.sup.4 together with the adjacent nitrogen atom form a heterocyclic group; A is C.sub.2.sub.-4 alkylene; and n is an integer of zero and 1; and pharmaceutically acceptable acid addition salts thereof are disclosed. They are useful as analgesics.

Abstract: Triazolothienodiazepine compounds of the formula; ##SPC1##Wherein X is a member selected from the group consisting of a hydrogen atom, a methyl group, a methoxy group and a trifluoromethyl group; each of R.sup.1 and R.sup.2 is a member selected from the group consisting of a hydrogen atom and an alkyl group having 1 to 4 carbon atoms, or R.sup.1 and R.sup.2 together can form a tetramethylene group, i.e.--(CH.sub.2).sub.4 --; R is a member selected from the group consisting of a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, --CONHR.sup.3 (R.sup.3 being an alkyl group having 1 to 4 carbon atoms) and -alk-N(R.sup. 4)(R.sup.5) (each of R.sup.4 and R.sup.5 being a member selected from the group consisting of a hydrogen atom and an alkyl group having 1 to 4 carbon atoms, or R.sup.4 and R.sup.

Abstract: Thiophene derivatives of the formula: ##SPC1##Wherein R.sup.1 is H or CH.sub.3 ; R.sup.2 is CH.sub.3 or C.sub.2 H.sub.5, or R.sup.1 and R.sup.2 combinedly represent --(CH.sub.2).sub.4 --; each of R.sup.3 and R.sup.4 is H, alkyl of from 1 to 4 carbon atoms or cyclohexyl, or R.sup.3 and R.sup.4 together with the adjacent nitrogen atom form 1-pyrrolidinyl, piperidino, 4-methyl-1-piperazinyl or morpholino; X is H, halogen or OCH.sub.3 ; A is -CH= or --C(CH.sub.3)=, and B is =N-- or =CH--; or A is --C(CH.sub.2 OH)= or --N=, and B is =N--, and pharmaceutically acceptable acid addition salts thereof possess excellent pharmacological properties such as sedative, anxiolytic and anticonvulsant effects and protective effects against hypoxia or anoxia.