Patents by Inventor Tetsuya TANINO

Tetsuya TANINO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Complex of nucleic acid medicine and multibranched lipid
    Patent number: 11638717
    Abstract: The purpose of the present invention is to provide novel complexes that improve the effect of nucleic acid medicines. Provided is a complex in which a multibranched lipid(s) binds through a linker to a strand of an oligonucleotide comprising a nucleic acid medicine having suppressing activity of the target gene expression.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: May 2, 2023
    Assignee: SHIONOGI & CO., LTD.
    Inventors: Akira Kugimiya, Mitsuaki Sekiguchi, Norikazu Kuroda, Jun Nakamura, Tetsuya Tanino, Yasunori Mitsuoka, Takeshi Kasuya, Yasuharu Kato
  • PRODUCTION METHOD FOR BIFURCATED LIPID-LINKED OLIGONUCLEOTIDE, AND INTERMEDIATE
    Publication number: 20220267771
    Abstract: Provided are production methods capable of controlling quality of a bifurcated lipid-linked oligonucleotide, and intermediates which is useful for the production method, has good stability, and is easy to manage and analyze. Specifically, it is a method for producing a bifurcated lipid-linked oligonucleotide including a step of reacting a compound of formula (II): wherein Pro1 to Pro4 are each independently a protecting group; Pro1 and Pro2 or Pro3 and Pro4 may be taken together to form a protecting group; m, n and p are each independently an integer of 0 to 5; and Y is a group of a formula: —P(OC2H4CN)(N(i-Pr)2), or the like, with an oligonucleotide.
    Type: Application
    Filed: June 2, 2020
    Publication date: August 25, 2022
    Applicant: Shionogi & Co., Ltd.
    Inventors: Tetsuya TANINO, Mitsuaki SEKIGUCHI, Shunsuke OCHI, Nobuaki FUKUI
  • Nucleic acid derivative having immunostimulatory activity
    Patent number: 10940201
    Abstract: The purpose of the present invention is to provide double-stranded oligonucleotides comprising the CpG oligonucleotide mentioned below, as a nucleic acid derivative having an immunostimulatory activity. An adjuvant comprising a double-stranded oligonucleotide, wherein a first strand is a CpG oligonucleotide consisting of 8 to 50 nucleotides, a second strand is an oligonucleotide consisting of 8 to 60 nucleotides and comprising a sequence capable of hybridizing with the first strand, and a lipid binds to the second strand through a linker.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: March 9, 2021
    Assignee: SHIONOGI & CO., LTD.
    Inventors: Akira Kugimiya, Tetsuya Tanino, Mitsuaki Sekiguchi, Yasunori Mitsuoka, Norikazu Kuroda, Jun Nakamura
  • COMPLEX OF NUCLEIC ACID MEDICINE AND MULTIBRANCHED LIPID
    Publication number: 20200384010
    Abstract: The purpose of the present invention is to provide novel complexes that improve the effect of nucleic acid medicines. Provided is a complex in which a multibranched lipid(s) binds through a linker to a strand of an oligonucleotide comprising a nucleic acid medicine having suppressing activity of the target gene expression.
    Type: Application
    Filed: March 28, 2018
    Publication date: December 10, 2020
    Applicant: SHIONOGI & CO., LTD.
    Inventors: Akira KUGIMIYA, Mitsuaki SEKIGUCHI, Norikazu KURODA, Jun NAKAMURA, Tetsuya TANINO, Yasunor MITSUOKA, Takeshi KASUYA, Yasuharu KATO
  • NUCLEIC ACID DERIVATIVE HAVING IMMUNOSTIMULATORY ACTIVITY
    Publication number: 20180264105
    Abstract: The purpose of the present invention is to provide double-stranded oligonucleotides comprising the CpG oligonucleotide mentioned below, as a nucleic acid derivative having an immunostimulatory activity. An adjuvant comprising a double-stranded oligonucleotide, wherein a first strand is a CpG oligonucleotide consisting of 8 to 50 nucleotides, a second strand is an oligonucleotide consisting of 8 to 60 nucleotides and comprising a sequence capable of hybridizing with the first strand, and a lipid binds to the second strand through a linker.
    Type: Application
    Filed: February 28, 2018
    Publication date: September 20, 2018
    Applicant: Shionogi & Co., Ltd.
    Inventors: Akira KUGIMIYA, Tetsuya TANINO, Mitsuaki SEKIGUCHI, Yasunori MITSUOKA, Norikazu KURODA, Jun NAKAMURA