Abstract: The present invention is intended to provide a technology that can utilize the advantages of both a load sensing control and a regeneration circuit without causing any problem. A regeneration circuit is added to a hydraulic circuit provided with a hydraulic pressure signal line for detecting a hydraulic pressure value of a circuit and controlling a volume of hydraulic fluid to a cylinder 1 with reference to the detected value. A pressure reducing valve 6 that outputs a reduced pressure as an operating signal to a pump 2, and subsequently the controlling means 5 causes the pressure reducing valve 6 to output a pressure reduction command to a pump 2 and thus to reduce a discharge rate from the pump 2, when the regeneration circuit is in a regeneration state.

Abstract: A method of controlling an electro-hydraulic system having an engine driving a variable displacement pump, a hydraulic valve and a hydraulic actuator in order to achieve more efficient engine operation is disclosed. The pressures in the electro-hydraulic system are monitored and commands are received indicating the desired movement of the hydraulic actuator. Based on the pressure and the commands, the operation being performed by the machine is determined and the engine is set to an efficient setting for the particular segment of machine operation.

Abstract: An objective of the present invention is to provide novel compounds which have inhibitory activity against autophosphorylation of an FGF receptor family and, when orally or intraveneously administered, can suppress the growth of cancer cells. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X represents CH or N; Z represents O or S; Q represents NR10, CR11R2, carbonyl, O, S(?O)m, wherein m is 0 to 2, or urea; R1 to R3 each independently represent H, OH, halogen, nitro, amino, alkyl, alkoxy or the like in which the alkyl and alkoxy groups are optionally substituted; R4 represents H; R5 to R8 each independently represent H, halogen, alkyl, or alkoxy; and R9 represents an optionally substituted carbocyclic or heterocyclic group.

Abstract: An objective of the present invention is to provide compounds and pharmaceuticals useful for the treatment of disease where the inhibition of autophosphorylation of FMS-like tyrosine kinase 3(Flt3) is therapeutically effective. The present invention relates to a pharmaceutical composition for use in the treatment or prevention of diseases where the inhibition of autophosphorylation of Flt3 therapeutically or prophylactically effective, which comprises a compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X represents CH or N; Z represents O or S; R1, R2, and R3 represent H, OH, or optionally substituted alkoxy; R4 represents H; R5, R6, R7, and R8 represent H, Hal, alkyl or the like; and R9 represents, e.g., alkyl substituted by t-butyl or the like.

Abstract: An objective of the present invention is to provide novel compounds which have inhibitory activity against autophosphorylation of an FGF receptor family and, when orally or intraveneously administered, can suppress the growth of cancer cells. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X represents CH or N; Z represents O or S; Q represents NR10, CR11R2, carbonyl, O, S(?O)m, wherein m is 0 to 2, or urea; R1 to R3 each independently represent H, OH, halogen, nitro, amino, alkyl, alkoxy or the like in which the alkyl and alkoxy groups are optionally substituted; R4 represents H; R5 to R8 each independently represent H, halogen, alkyl, or alkoxy; and R9 represents an optionally substituted carbocyclic or heterocyclic group.

Abstract: A hydraulic control circuit for a boom cylinder in a work machine, which, when controlling supply and discharge of pressurized oil with respect to a boom cylinder, improves fuel efficiency, work efficiency in combined operations, and improves work efficiency and operationality in the work of difficult boom operations, such as debris raking-up work and bumping work, wherein the hydraulic control circuit of a boom cylinder is provided with a change valve to hold a first boom control valve at a neutral position, a communication line for causing a head side oil chamber and a rod side oil chamber to communicate with each other, an opening valve for opening and closing the corresponding communication line, and pilot operating check valve that is changed to an unidirectional state where, although an oil flow from the head side oil chamber to the rod side oil chamber is permitted, a reverse flow is hindered, and to a bi-directional state where oil flows in both directions, and further a second boom control valve is p

Abstract: A hydraulic control circuit of a boom cylinder for a work machine, which, when controlling the supply and discharge of pressurized oil with respect to a boom cylinder, improves fuel efficiency, work efficiency in combined operations, and work efficiency and operationality in work of difficult boom operations, such as debris raking-up work and bumping work, etc. The hydraulic control circuit of a boom cylinder is provided with a first change valve for holding the boom control valve in the neutral position, a communication line for causing the head side oil chamber and the rod side oil chamber to communicate with each other, an opening and closing valve for opening and closing the communication line, and a pilot operation check valve that is changed to an unidirectional state where, although an oil flow from the head side oil chamber to the rod side oil chamber is permitted, a reverse flow is hindered, and a bi-directional state is permitted where the oil flows in both directions.

Abstract: A hydraulic control circuit of a boom cylinder for a work machine, which, when controlling the supply and discharge of pressurized oil with respect to a boom cylinder, improves fuel efficiency, work efficiency in combined operations, and work efficiency and operationality in work of difficult boom operations, such as debris raking-up work and bumping work, etc. The hydraulic control circuit of a boom cylinder is provided with a first change valve for holding the boom control valve in the neutral position, a communication line for causing the head side oil chamber and the rod side oil chamber to communicate with each other, an opening and closing valve for opening and closing the communication line, and a pilot operation check valve that is changed to an unidirectional state where, although an oil flow from the head side oil chamber to the rod side oil chamber is permitted, a reverse flow is hindered, and a bi-directional state is permitted where the oil flows in both directions.

Abstract: The invention relates to a hydraulic control circuit for a boom cylinder in a work machine, which, when controlling supply and discharge of pressurized oil with respect to a boom cylinder, improves fuel efficiency, work efficiency in combined operations, and improves work efficiency and operationality in work of difficult boom operations such as debris raking-up work and bumping work, etc.

Abstract: A pilot-operated proportional control electromagnetic relief valve has a needle guide portion snugly fitted around the outer surface of a needle. The needle guide portion guides vertical movement of the needle, and is located at the center of a stopper so as to be coaxial with the stopper. A cylindrical inner wall portion of the stopper is so bored in the lower part of the adapter as to be coaxial with the needle guide portion. A cylindrical outer wall portion to be snugly fitted in the cylindrical inner positioning wall portion is so formed around the outer surface of a seat as to be coaxial with the seat portion. The outer circumferential surface of the needle is snugly fitted in the needle guide portion of the adapter so that the needle guide portion guides the axial travel of the needle, and the cylindrical inner wall portion of the adapter and the cylindrical outer wall portion of the seat are snugly fitted together.

Abstract: A coating apparatus wherein the coating is made by a coater while a support is carried in a non-contacting manner by a gas jetted from a gas jetting device towards the support. The gas jetting device has a hollow housing into which the gas is introduced from a gas source, the wall of the housing adjacent to the support being provided with a plurality of gas jetting nozzle ports through which the gas is jetted towards the support, each gas jetting nozzle port having a throat portion presenting a minimum cross-sectional area inwardly spaced from the outer surface of the wall of the housing and an enlarged outlet portion presenting a comparatively large diameter and opening in surface of the wall. The ratio of port area is adjusted in such a manner that the rate of jetting of the gas from unit area of the outer surface of the gas jetting device becomes smaller as the width of the support is increased.

Abstract: A method and an apparatus in which gas is jetted out of the gas injector 3' to support the support 2 in a contactless manner, while coating solutions are applied onto both sides of the support 2 by means of the coaters 1 and 1'. Supporting static pressure produced in a gap between the support 2 and the injector 3' is made to become 1/10 through 1/1000 of supply pressure of gas fed into the injector 3', and a lift of the support 2 at the contact point with the coating solution from the coater is made to have a value of 20 through 500.mu..