Patents by Inventor Tetsuyoshi Hayashi

Tetsuyoshi Hayashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Triterpene derivatives and endothelin-receptor antagonists containing the same
    Patent number: 5587505
    Abstract: Triterpene derivatives of the formula (I): ##STR1## wherein R.sup.1 is hydrogen or metabolic ester residue; and R.sup.2 is hydrogen or --R.sup.3 -R.sup.4 wherein R.sup.3 is --SO.sub.3 --, --CH.sub.2 COO--, --COCOO--, or --COR.sup.5 COO-- (R.sup.5 is lower alkylene or lower alkenylene), and R.sup.4 is hydrogen or metabolic ester residue or a pharmaceutically acceptable salt thereof, which have anti-endothelin activities and are useful in prophylaxis and treatment of diseases caused by excessive secretion of endothelin.
    Type: Grant
    Filed: July 26, 1995
    Date of Patent: December 24, 1996
    Assignee: Shionogi & Co., Ltd.
    Inventors: Toshiro Konoike, Yoshitaka Araki, Tetsuyoshi Hayashi, Kensuke Sakurai, Takehiko Tozyo
  • Triterpene derivatives and endothelin-receptor antagonists containing the same
    Patent number: 5463107
    Abstract: Triterpene derivatives of the formula (I): ##STR1## wherein R.sup.1 is hydrogen or metabolic ester residue; and R.sup.2 is hydrogen or --R.sup.3 --R.sup.4 wherein R.sup.3 is --SO.sub.3 --, --CH.sub.2 COO--, --COCOO--, or --COR.sup.5 COO-- (R.sup.5 is lower alkylene or lower alkenylene), and R.sup.4 is hydrogen or metabolic ester residue or a pharmaceutically acceptable salt thereof, which have anti-endothelin activities and are useful in prophylaxis and treatment of diseases caused by excessive secretion of endothelin.
    Type: Grant
    Filed: June 10, 1994
    Date of Patent: October 31, 1995
    Assignee: Shionogi & Co., Ltd.
    Inventors: Toshiro Konoike, Yoshitaka Araki, Tetsuyoshi Hayashi, Kensuke Sakurai, Takehiko Tozyo