Abstract: A method of treating a hyperproliferative disorder in a subject in need of such treatment, comprising administering to said subject, in combination, a treatment effective amount of: (a) a ceramide-increasing retinoid such as fenretinide or a pharmaceutically acceptable salt thereof; and (b) at least one (and in certain embodiments at least two) compounds selected from the groups consisting of (i) a non-18 carbon chain length L-threo-sphinganine(s) or pharmaceuticeutically acceptable salt thereof, (ii) glucosylceramide or glucosyl(dihydro)ceramide synthesis inhibitor(s), and (iii) sphingomyelin or dihydrosphingomyelin synthase inhibitor(s). Preferred L-threo-sphinganines are of carbon chain length 17 carbons, 19 carbons and 20 carbons. A preferred glucosylceramide or glucosyl(dihydro)ceramide synthesis inhibitor is D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol. A preferred sphingomyelin or dihydrosphingomyelin synthesis inhibitor is D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol.

Abstract: A system, method and apparatus tracks targets (e.g., tumors) during treatment (e.g., radiation therapy) using a radar motion sensor by generating a microwave signal, radiating the microwave signal to a subject, and receiving a modulated microwave signal from the subject. The modulated microwave signal is processed to provide a subject motion information using a sensor having an arctangent-demodulation microwave interferometry mode. A location of a target on or within the subject is determined based on the subject motion information and a three-dimensional model for the subject and the target. One or more control signals are generated based on the location of the target, and the treatment device is controlled using the one or more control signals to treat the target on or within the subject.

Abstract: Antibacterial metallic nanofoams, substrates having the nanofoam coated thereon, methods for preventing, inhibiting, and/or killing bacterial growth using the metallic nanofoams, and compositions and methods for making the metallic nanofoams.