Patents by Inventor Thad Sharp

Thad Sharp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods to generate epithelial cells
    Patent number: 10920195
    Abstract: The invention provides in certain embodiments, a method of generating a re-programmed differentiated epithelial cell comprising (a) contacting a non-stem somatic cell obtained from a subject with an effective amount of a de-differentiation agent to form a de-differentiated cell, and (b) transfecting the de-differentiated cell with an expression cassette comprising a promoter operably linked to a nucleic acid encoding a conversion agent to form a re-programmed differentiated cell. The invention also provides in certain embodiments, a method of generating a re-programmed differentiated epithelial cell comprising (a) contacting a non-stem somatic cell obtained from a subject with an effective amount of a de-differentiation agent to form a de-differentiated cell, and (b) contacting the de-differentiated cell with a conversion agent to form a re-programmed differentiated cell.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: February 16, 2021
    Assignee: University of Iowa Research Foundation
    Inventors: Brad A. Amendt, Thad Sharp
  • MicroRNA-200 based approaches for modulating bone formation inhibition and bone regeneration
    Patent number: 10717980
    Abstract: In certain embodiments, the present invention provides the use of microRNA (miR)-200a to inhibit ossification and bone formation.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: July 21, 2020
    Assignee: University of Iowa Research Foundation
    Inventors: Liu Hong, Brad Amendt, Thad Sharp, Aliasger Salem
  • Methods to prevent or treat periodontitis or peri-implantitis
    Patent number: 10669543
    Abstract: Compositions and methods to prevent, inhibit or treat aveolar or periodontal bone loss, enhance bone regeneration, prevent, inhibit or treat peri-implantitis or periodontitis, e.g., periodontitis or peri-implantitis associated with bone loss, or to prevent, inhibit or treat osteoarthritis are provided.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: June 2, 2020
    Assignee: University of Iowa Research Foundation
    Inventors: Liu Hong, Brad A. Amendt, Aliasger K. Salem, Satheesh Elangovan, Gustavo Avila Ortiz, Thad Sharp
  • MICRORNA-200 BASED APPROACHES FOR MODULATING BONE FORMATION INHIBITION AND BONE REGENERATION
    Publication number: 20190264206
    Abstract: In certain embodiments, the present invention provides the use of microRNA (miR)-200a to inhibit ossification and bone formation.
    Type: Application
    Filed: March 12, 2019
    Publication date: August 29, 2019
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Liu Hong, Brad Amendt, Thad Sharp, Aliasger Salem
  • METHODS TO PREVENT OR TREAT PERIODONTITIS OR PERI-IMPLANTITIS
    Publication number: 20190144856
    Abstract: Compositions and methods to prevent, inhibit or treat aveolar or periodontal bone loss, enhance bone regeneration, prevent, inhibit or treat peri-implantitis or periodontitis, e.g., periodontitis or peri-implantitis associated with bone loss, or to prevent, inhibit or treat osteoarthritis are provided.
    Type: Application
    Filed: January 15, 2016
    Publication date: May 16, 2019
    Applicant: University of Iowa Research Foundation
    Inventors: Liu HONG, Brad A. AMENDT, Aliasger K. SALEM, Satheesh ELANGOVAN, Gustavo Avila Ortiz, Thad SHARP
  • MicroRNA-200 based approaches for modulating bone formation inhibition and bone regeneration
    Patent number: 10273476
    Abstract: In certain embodiments, the present invention provides the use of microRNA (miR)-200a and/or miR-200c to inhibit ossification and bone formation. In certain embodiments, the present invention provides the use of miR-200a inhibitor to stimulate bone regeneration.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: April 30, 2019
    Assignee: University of Iowa Research Foundation
    Inventors: Liu Hong, Brad Amendt, Thad Sharp, Aliasger Salem
  • METHODS TO GENERATE EPITHELIAL CELLS
    Publication number: 20170321190
    Abstract: The invention provides in certain embodiments, a method of generating a re-programmed differentiated epithelial cell comprising (a) contacting a non-stem somatic cell obtained from a subject with an effective amount of a de-differentiation agent to form a de-differentiated cell, and (b) transfecting the de-differentiated cell with an expression cassette comprising a promoter operably linked to a nucleic acid encoding a conversion agent to form a re-programmed differentiated cell. The invention also provides in certain embodiments, a method of generating a re-programmed differentiated epithelial cell comprising (a) contacting a non-stem somatic cell obtained from a subject with an effective amount of a de-differentiation agent to form a de-differentiated cell, and (b) contacting the de-differentiated cell with a conversion agent to form a re-programmed differentiated cell.
    Type: Application
    Filed: August 13, 2015
    Publication date: November 9, 2017
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Brad A. Amendt, Thad Sharp
  • MICRORNA-200 BASED APPROACHES FOR MODULATING BONE FORMATION INHIBITION AND BONE REGENERATION
    Publication number: 20170314020
    Abstract: In certain embodiments, the present invention provides the use of microRNA (miR)-200a and/or miR-200c to inhibit ossification and bone formation. In certain embodiments, the present invention provides the use of miR-200a inhibitor to stimulate bone regeneration.
    Type: Application
    Filed: May 1, 2017
    Publication date: November 2, 2017
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Liu Hong, Brad Amendt, Thad Sharp, Aliasger Salem
  • Diagnostic Test for Susceptibility to B-RAF Kinase Inhibitors
    Publication number: 20170067122
    Abstract: The present invention provides methods and reagents for the detection of a mutation in BRAF and methods of selecting patients for treatment if a B-Raf kinase inhibitor, such as a selective B-Raf kinase inhibitor.
    Type: Application
    Filed: November 4, 2016
    Publication date: March 9, 2017
    Inventors: Rachael Langland, Lin Wu, Thad Sharp, Stephen Will
  • Diagnostic Test for Susceptibility to B-RAF Kinase Inhibitors
    Publication number: 20110212991
    Abstract: The present invention provides methods and reagents for the detection of a mutation in BRAF and methods of selecting, patients for treatment if a B-Raf kinase inhibitor, such as a selective B-Raf kinase inhibitor.
    Type: Application
    Filed: January 27, 2011
    Publication date: September 1, 2011
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Rachel Langland, Lin Wu, Thad Sharp, Stephen Will
  • DIAGNOSTIC TEST FOR SUSCEPTIBILITY TO B-RAF KINASE INHIBITORS
    Publication number: 20100173294
    Abstract: The present invention provides methods and reagents for the detection of a mutation in BRAF and methods of selecting patients for treatment if a B-Raf kinase inhibitor, such as a selective B-Raf kinase inhibitor
    Type: Application
    Filed: July 30, 2009
    Publication date: July 8, 2010
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Rachel Langland, Lin Wu, Thad Sharp, Stephen Will