Abstract: The present invention relates to the determination of expression or activity levels of particular biomarkers in biological samples which can be utilized to diagnose, prognose, and treat cancer in individuals, and further to select individuals who would benefit from a cancer therapy such as treatment with a one or more agent(s) that inhibit cancer cell viability and/or proliferation. Accordingly, the present invention encompasses methods that utilize these biomarkers for the diagnosis, prognosis, and treatment of cancer as well as screening for compounds that reduce the risk of an individual developing cancer, reduce the risk of an individual developing one or more symptoms of cancer, and alleviate one or more symptoms of cancer in an individual.

Abstract: The present disclose includes, among other things, compounds that treat or lessen the severity of cancer, pharmaceutical compositions and methods of making and using the same.

Abstract: The present disclose includes, among other things, compounds that treat or lessen the severity of cancer, pharmaceutical compositions and methods of making and using the same.

Abstract: The present disclose includes, among other things, compounds that treat or lessen the severity of cancer, pharmaceutical compositions and methods of making and using the same.

Abstract: The present disclose includes, among other things, compounds that treat or lessen the severity of a disorder, pharmaceutical compositions and methods of making and using the same.

Abstract: In certain aspects, disclosed herein are methods of treating cancer in a subject, comprising administration to the subject of (1) one or more glucocorticoid receptor agonists and (2) one or more inhibitors of calcineurin. In some embodiments, the administration of the one or more glucocorticoid receptor agonists and the one or more inhibitors of calcineurin results in restoration of contact inhibition, increased formation of intercellular junctions, reduced cell proliferation, and/or increased vacuolization of cells growing in multilayer zones. Included herein are methods for identification of novel compounds that restore contact inhibition in cancer cells.