Patents by Inventor Thaddeus C George
Thaddeus C George has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9528989Abstract: The use of an imaging system, cell compartment markers, and molecular markers in methods for correlating the movement of molecules within a cell to a particular compartment are provided, including measuring and correlating molecule movement in adherent and non-adherent cells.Type: GrantFiled: March 30, 2012Date of Patent: December 27, 2016Assignee: Amnis CorporationInventors: Thaddeus C. George, David A. Basiji, Keith Frost, Brian E. Hall, William E. Ortyn, Michael J. Seo
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Patent number: 8953866Abstract: Provided are methods for determining and analyzing photometric and morphometric features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.Type: GrantFiled: April 30, 2012Date of Patent: February 10, 2015Assignee: Amnis CorporationInventors: Thaddeus C. George, David A. Basiji, Brian E. Hall, William E. Ortyn, Michael J. Seo, Philip J. Morrissey, Cathleen A. Zimmerman
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Patent number: 8824770Abstract: Provided are methods for determining and analyzing photometric and morphometric features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.Type: GrantFiled: March 13, 2013Date of Patent: September 2, 2014Assignee: Amnis CorporationInventors: Thaddeus C. George, David A. Basiji, Brian E. Hall, William E. Ortyn, Michael J. Seo, Philip J. Morrissey, Cathleen A. Zimmerman
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Patent number: 8660332Abstract: Multimodal or multispectral images of cells comprising a population of cells are simultaneously collected. Photometric and/or morphometric image features identifiable in the images are used to identify differences between first and second populations of cells. The differences can include changes in a relative percentage of different cell types in each population, or a change in a first type of cell present in the first population of cells and the same type of cell in the second population of cells. The changes may be indicative of a disease state, indicative of a relative effectiveness of a therapy, or indicative of a health of the person from whom the cells populations were obtained.Type: GrantFiled: March 13, 2013Date of Patent: February 25, 2014Assignee: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, Philip J. Morrissey, Thaddeus C. George, Brian E. Hall, Cathleen A. Zimmerman, David J. Perry
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Patent number: 8571294Abstract: Provided are methods for determining and analyzing photometric and morphometric features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.Type: GrantFiled: November 22, 2011Date of Patent: October 29, 2013Assignee: Amnis CorporationInventors: Thaddeus C. George, David A. Basiji, Brian E. Hall, William E. Ortyn, Michael E. Seo, Phillip J. Morrissey, Cathleen A. Zimmerman
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Patent number: 8571295Abstract: Provided are methods for determining and analyzing photometric and morphometric features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.Type: GrantFiled: March 13, 2013Date of Patent: October 29, 2013Assignee: Amnis CorporationInventors: Thaddeus C. George, David A. Basiji, Brian E. Hall, William E. Ortyn, Michael J. Seo, Philip J. Morrissey, Cathleen A. Zimmerman
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Publication number: 20130251234Abstract: Provided are methods for determining and analyzing photometric and morphometric features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.Type: ApplicationFiled: March 13, 2013Publication date: September 26, 2013Inventors: Thaddeus C. George, David A. Basiji, Brian E. Hall, William E. Ortyn, Michael J. Seo, Philip J. Morrissey, Cathleen A. Zimmerman
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Publication number: 20120328177Abstract: Provided are methods for determining and analyzing photometric and morphometric features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.Type: ApplicationFiled: April 30, 2012Publication date: December 27, 2012Applicant: AMNIS CORPORATIONInventors: Thaddeus C. George, David A. Basiji, Brian E. Hall, William E. Ortyn, Michael J. Seo, Philip J. Morrissey, Cathleen A. Zimmerman
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Publication number: 20120244550Abstract: The use of an imaging system, cell compartment markers, and molecular markers in methods for correlating the movement of molecules within a cell to a particular compartment are provided, including measuring and correlating molecule movement in adherent and non-adherent cells.Type: ApplicationFiled: March 30, 2012Publication date: September 27, 2012Applicant: AMNIS CORPORATIONInventors: Thaddeus C. George, David A. Basiji, Keith Frost, Brian E. Hall, William E. Ortyn, Michael J. Seo
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Patent number: 8175371Abstract: Provided are methods for determining and analyzing photometric and morphogenic features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.Type: GrantFiled: July 26, 2011Date of Patent: May 8, 2012Assignee: Amnis CorporationInventors: Thaddeus C. George, David A. Basiji, Brian E. Hall, William E. Ortyn, Michael E. Seo, Phillip J. Morrissey, Cathleen A. Zimmerman
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Publication number: 20120100532Abstract: Provided are methods for determining and analyzing photometric and morphometric features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.Type: ApplicationFiled: November 22, 2011Publication date: April 26, 2012Applicant: AMNIS CORPORATIONInventors: Thaddeus C. George, David A. Basiji, Brian E. Hall, William E. Ortyn, Michael J. Seo, Philip J. Morrissey, Cathleen A. Zimmerman
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Patent number: 8150136Abstract: The use of an imaging system, cell compartment markers, and molecular markers in methods for correlating the movement of molecules within a cell to a particular compartment are provided, including measuring and correlating molecule movement in adherent and non-adherent cells.Type: GrantFiled: March 16, 2005Date of Patent: April 3, 2012Assignee: Amnis CorporationInventors: Thaddeus C. George, David A. Basiji, Keith Frost, Brian E. Hall, William E. Ortyn, Michael J. Seo
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Patent number: 8103080Abstract: Provided are methods for determining and analyzing photometric and morphogenic features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.Type: GrantFiled: March 16, 2005Date of Patent: January 24, 2012Assignee: Amnis CorporationInventors: Thaddeus C George, David A Basiji, Brian E Hall, William E Ortyn, Michael J Seo, Philip J Morrissey, Cathleen A Zimmerman
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Publication number: 20110280467Abstract: Provided are methods for determining and analyzing photometric and morphogenic features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.Type: ApplicationFiled: July 26, 2011Publication date: November 17, 2011Applicant: Amnis CorporationInventors: Thaddeus C. George, David A. Basiji, Brian E. Hall, William E. Ortyn, Michael J. Seo, Philip J. Morrissey, Cathleen A. Zimmerman
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Publication number: 20090202130Abstract: The use of an imaging system, cell compartment markers, and molecular markers in methods for correlating the movement of molecules within a cell to a particular compartment are provided, including measuring and correlating molecule movement in adherent and non-adherent cells.Type: ApplicationFiled: March 16, 2005Publication date: August 13, 2009Applicant: AMNIS CORPORATIONInventors: Thaddeus C. George, David A. Basiji, Keith Frost, Brian E. Hall, William E. Ortyn, Michael J. Seo
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Publication number: 20080240539Abstract: Provided are methods for determining and analyzing photometric and morphogenic features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.Type: ApplicationFiled: March 16, 2005Publication date: October 2, 2008Applicant: Amins CorporationInventors: Thaddeus C. George, David A. Basiji, Brian E. Hall, William E. Ortyn, Michael J. Seo, Philip J. Morrissey, Cathleen A. Zimmerman
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Publication number: 20030049696Abstract: Regulatory T cell subpopulation (Treg) are isolated for a human host by selection for cells expressing CD4 and CD25. The Treg cells are further characterized by expression of CTLA-4, CCR6, and CD30. In addition, the Treg cells are CD62Lhi, CD45RBlo, CD45ROhi, CD45RA−. The Treg cells of the invention reflect the immunologic status of the donor, in terms of the number, location and T cell antigen receptor specificity of the Treg cells. This information is used in diagnostic assays relating to immunologic disorders, e.g. cancer related immunosuppression; autoimmune disorders; atopic states, etc. The isolated Treg cells are useful in transplantation, for experimental evaluation, and as a source of subset and cell specific products, including mRNA species useful in identifying genes specifically expressed in these cells, and as targets for the discovery of factors or molecules that can affect them.Type: ApplicationFiled: June 6, 2002Publication date: March 13, 2003Inventors: Anne M. Norment, Thaddeus C. George