Patents by Inventor Thaddeus George
Thaddeus George has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8406498Abstract: Multimodal or multispectral images of cells comprising a population of cells are simultaneously collected. Photometric and/or morphometric image features identifiable in the images are used to identify differences between first and second populations of cells. The differences can include changes in a relative percentage of different cell types in each population, or a change in a first type of cell present in the first population of cells and the same type of cell in the second population of cells. The changes may be indicative of a disease state, indicative of a relative effectiveness of a therapy, or indicative of a health of the person from whom the cells populations were obtained.Type: GrantFiled: December 4, 2009Date of Patent: March 26, 2013Assignee: Amnis CorporationInventors: William Ortyn, David Basiji, Philip Morrissey, Thaddeus George, Brian Hall, Cathleen Zimmerman, David Perry
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Patent number: 7925069Abstract: Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected.Type: GrantFiled: September 29, 2009Date of Patent: April 12, 2011Assignee: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, Philip Morrissey, Thaddeus George, Brian Hall, Cathleen Zimmerman, David Perry
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Publication number: 20100232675Abstract: Multimodal or multispectral images of cells comprising a population of cells are simultaneously collected. Photometric and/or morphometric image features identifiable in the images are used to identify differences between first and second populations of cells. The differences can include changes in a relative percentage of different cell types in each population, or a change in a first type of cell present in the first population of cells and the same type of cell in the second population of cells. The changes may be indicative of a disease state, indicative of a relative effectiveness of a therapy, or indicative of a health of the person from whom the cells populations were obtained.Type: ApplicationFiled: December 4, 2009Publication date: September 16, 2010Applicant: Amnis CorporationInventors: William Ortyn, David Basiji, Philip Morrissey, Thaddeus George, Brian Hall, Cathleen Zimmerman, David Perry
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Publication number: 20100021039Abstract: Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected.Type: ApplicationFiled: September 29, 2009Publication date: January 28, 2010Applicant: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, Philip Morrissey, Thaddeus George, Brian Hall, Cathleen Zimmerman, David Perry
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Patent number: 7634125Abstract: Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected.Type: GrantFiled: August 20, 2008Date of Patent: December 15, 2009Assignee: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, Philip Morrissey, Thaddeus George, Brian Hall, Cathleen Zimmerman, David Perry
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Patent number: 7634126Abstract: Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected.Type: GrantFiled: January 29, 2009Date of Patent: December 15, 2009Assignee: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, Philip Morrissey, Thaddeus George, Brian Hall, Cathleen Zimmerman, David Perry
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Publication number: 20090190822Abstract: Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected.Type: ApplicationFiled: January 29, 2009Publication date: July 30, 2009Applicant: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, Philip Morrissey, Thaddeus George, Brian Hall, Cathleen Zimmerman, David Perry
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Patent number: 7522758Abstract: Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected.Type: GrantFiled: February 1, 2006Date of Patent: April 21, 2009Assignee: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, Philip Morrissey, Thaddeus George, Brian Hall, Cathleen Zimmerman, David Perry
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Publication number: 20090003681Abstract: Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected.Type: ApplicationFiled: August 20, 2008Publication date: January 1, 2009Applicant: Amnis CorporationInventors: William E. Ortyn, David A. Basiji, Philip Morrissey, Thaddeus George, Brian Hall, Cathleen Zimmerman, David Perry
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Publication number: 20060204071Abstract: Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected.Type: ApplicationFiled: February 1, 2006Publication date: September 14, 2006Applicant: Amnis CorporationInventors: William Ortyn, David Basiji, Philip Morrissey, Thaddeus George, Brian Hall, Cathleen Zimmerman, David Perry
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Publication number: 20060063256Abstract: Regulatory T cell subpopulation (Treg) are isolated for a human host by selection for cells expressing CD4 and CD25. The Treg cells are further characterized by expression of CTLA-4, CCR6, and CD30. In addition, the Treg cells are CD62Lhi, CD45RBlo, CD45ROhi, CD45RA?. The Treg cells of the invention reflect the immunologic status of the donor, in terms of the number, location and T cell antigen receptor specificity of the Treg cells. This information is used in diagnostic assays relating to immunologic disorders, e.g. cancer related immunosuppression; autoimmune disorders; atopic states, etc. The isolated Treg cells are useful in transplantation, for experimental evaluation, and as a source of subset and cell specific products, including mRNA species useful in identifying genes specifically expressed in these cells, and as targets for the discovery of factors or molecules that can affect them.Type: ApplicationFiled: November 7, 2005Publication date: March 23, 2006Inventors: Anne Norment, Thaddeus George