Patents by Inventor Thaddeus P. Dryja

Thaddeus P. Dryja has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Retinoblastoma nucleic acids
    Patent number: 7384735
    Abstract: This invention relates to nucleic acid, or fragments thereof, encoding the retinoblastoma polypeptide, the retinoblastoma polypeptide itself, methods of detecting a defective retinoblastoma gene in human patients, and methods of treating these patients.
    Type: Grant
    Filed: August 31, 1999
    Date of Patent: June 10, 2008
    Assignees: Massachusetts Eye and Ear Infirmary, Whitehead Institute
    Inventors: Thaddeus P. Dryja, Stephen Friend, David W. Yandell
  • Detection of proteins whose absence is associated with a neoplasm
    Patent number: 7223842
    Abstract: This invention relates to nucleic acid, or fragments thereof, encoding the retinoblastoma polypeptide, the retinoblastoma polypeptide itself, methods of detecting a defective retinoblastoma gene in human patients, and methods of treating these patients.
    Type: Grant
    Filed: June 8, 1994
    Date of Patent: May 29, 2007
    Assignees: Massachusetts Eye and Ear Infirmary, Whitehead Institute
    Inventors: Thaddeus P. Dryja, Stephen Friend
  • Method for determining eye disorders by determining mutations in 11-cis retinol dehydrogenase
    Publication number: 20020119543
    Abstract: The invention relates to mutations in the gene encoding 11-cis retinal dehyrogenase. The mutations in the gene and in the resulting encoded protein are correlated to ocular disorders, such as fundus albipunctatus.
    Type: Application
    Filed: November 14, 2001
    Publication date: August 29, 2002
    Inventors: Andras Simon, Ulf Eriksson, Thaddeus P. Dryja, Eliot L. Berson, Hioyuji Yamamoto
  • Mutations in nucleic acid molecules encoding 11-CIS retinol dehydrogenase, the mutated proteins, and uses thereof
    Patent number: 6372463
    Abstract: The invention relates to mutations in the gene encoding 11-cis retinal dehyrogenase. The mutations in the gene and in the resulting encoded protein are correlated to ocular disorders, such as fundus albipunctatus.
    Type: Grant
    Filed: May 6, 1999
    Date of Patent: April 16, 2002
    Assignees: The President & Fellows of Harvard College, Massachusette Eye & Ear Infirmary, Ludwig Institute for Cancer Research
    Inventors: András Simon, Ulf Eriksson, Thaddeus P. Dryja, Eliot L. Berson, Hioyuji Yamamoto
  • Mutations in nucleic acid molecules encoding 11-CIS retinol dehydrogenase, the mutated proteins, and uses thereof
    Publication number: 20020042116
    Abstract: The invention relates to mutations in the gene encoding 11-cis retinal dehyrogenase. The mutations in the gene and in the resulting encoded protein are correlated to ocular disorders, such as fundus albipunctatus.
    Type: Application
    Filed: June 13, 2001
    Publication date: April 11, 2002
    Inventors: Andras Simon, Ulf Eriksson, Thaddeus P. Dryja, Eliot L. Berson, Hioyuji Yamamoto
  • Diagnosis of retinoblastoma
    Patent number: 5853988
    Abstract: This invention relates to nucleic acid, or fragments thereof, encoding the retinoblastoma polypeptide, the retinoblastoma polypeptide itself, methods of detecting a defective retinoblastoma gene in human patients, and methods of treating these patients.
    Type: Grant
    Filed: October 8, 1992
    Date of Patent: December 29, 1998
    Assignees: Massachusetts Eye and Ear Infirmary, Whitehead Institute
    Inventors: Thaddeus P. Dryja, Stephen Friend, David W. Yandell
  • Diagnosis of hereditary retinal degenerative diseases
    Patent number: 5498521
    Abstract: The invention generally provides a method of diagnosing in a human subject an increased likelihood of developing or transmitting to future generations a disease in which a mutant form of a human photoreceptor protein is a causative agent. The method involves analyzing the DNA of the subject to determine the presence or absence of a mutation in a gene for a photoreceptor protein.
    Type: Grant
    Filed: March 11, 1993
    Date of Patent: March 12, 1996
    Assignee: President and Fellows of Harvard College
    Inventors: Thaddeus P. Dryja, Eliot L. Berson
  • Diagnosis of hereditary retinal degenerative diseases
    Patent number: 5262529
    Abstract: A probe/primer which includes a substantially purified single-stranded oligonucleotide containing a region the sequence of which is identical to the sequence of a six-nucleotide, single-stranded segment of a gene encoding a mutant form of a human photoreceptor protein, which segment includes the mutation; and methods of making and using such probe/primer.
    Type: Grant
    Filed: December 11, 1991
    Date of Patent: November 16, 1993
    Assignee: President and Fellows of Harvard College
    Inventors: Thaddeus P. Dryja, Eliot L. Berson
  • Diagnosis of hereditary retinal degenerative disease
    Patent number: 5225546
    Abstract: A probe/primer which includes a substantially purified single stranded oligonucleotide containing a region the sequence of which is identical to the sequence of a six-nucleotide, single-stranded segment of a gene encoding a mutant form of a human photoreceptor protein, which segment includes the mutation; and methods of making and using such probe/primer.
    Type: Grant
    Filed: January 23, 1992
    Date of Patent: July 6, 1993
    Assignee: President and Fellows of Harvard College
    Inventors: Thaddeus P. Dryja, Eliot L. Berson