Patents by Inventor Thaddeus Stappenbeck

Thaddeus Stappenbeck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210223265
    Abstract: The present disclosure provides methods for classifying a cell as abnormal based on HD5 protein detection as well as methods for predicting prognosis of a subject with Crohn's disease based on HD5 protein detection.
    Type: Application
    Filed: April 27, 2017
    Publication date: July 22, 2021
    Applicant: Washington University
    Inventors: Thaddeus Stappenbeck, Ta-Chiang Liu, Kelli VanDussen
  • Patent number: 11058653
    Abstract: The disclosure provides compositions comprising desaminotyrosine and methods of use thereof in enhancing type I interferon stimulation, epithelial proliferation, and treatment of inflammatory bowel disease.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: July 13, 2021
    Assignee: Washington University
    Inventors: Thaddeus Stappenbeck, Ashley Steed, Gerard Kaiko, George Christophi
  • Publication number: 20200165677
    Abstract: Among the various aspects of the present disclosure is the provision of methods of diagnosing and treating inflammatory bowel disease (IBD) including ulcerative colitis (UC) or Crohn's disease (CD). In particular, the present disclosure provides in part a panel of IBD biomarkers useful in diagnosing and making treatment decisions. In addition, the present disclosure provides methods of treating IBD with a plasminogen activator inhibitor-1 (PAI-1) inhibitor or tissue plasminogen activator (tPA).
    Type: Application
    Filed: July 18, 2018
    Publication date: May 28, 2020
    Inventors: Thaddeus Stappenbeck, Gerard Kaiko, Ta-Chiang Liu
  • Publication number: 20190274983
    Abstract: The disclosure provides compositions comprising desaminotyrosine and methods of use thereof in enhancing type I interferon stimulation, epithelial proliferation, and treatment of inflammatory bowel disease.
    Type: Application
    Filed: October 26, 2017
    Publication date: September 12, 2019
    Applicant: Washington University
    Inventors: Thaddeus Stappenbeck, Ashley Steed, Gerard Kaiko, George Christophi
  • Publication number: 20050037955
    Abstract: The present invention relates to microbial (antibacterial and antifungal) and other therapeutic treatments for diseases, in particular but not limited to the intestine, based upon angiogenins, and particularly angiogenin-4: a novel intestine-specific, epithelial-based, microbially-regulated member of the angiogenin family. Novel proteins as well as their use in screening for pharmaceuticals are also described.
    Type: Application
    Filed: November 27, 2002
    Publication date: February 17, 2005
    Inventors: Laura Hooper, Thaddeus Stappenbeck, Chieu Hong, Jeffrey Gordon