Patents by Inventor Thai V. Truong
Thai V. Truong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11397311Abstract: Volumetric imaging with selective volume illumination (SVI) using light field detection is provided using various systems and techniques. A volumetric imaging apparatus includes a light source configured to emit an illumination light that propagates via an illumination light path to illuminate a three-dimensional (3D) sample; and an optical system arranged with respect to the light source to receive a light field, which comes from the illuminated 3D sample. The light field propagates via a detection light path, and the light source, the optical system, or both, are configurable to perform SVI, which selects a volume of a 3D-confined illumination of the 3D sample based on the 3D sample to be illuminated and a light field detection (LFD) process to be applied. Further, the volume of the 3D-confined illumination is a selected 3D volume of the 3D sample to be particularly excited by the 3D-confined illumination for imaging.Type: GrantFiled: January 4, 2021Date of Patent: July 26, 2022Assignee: University of Southern CaliforniaInventors: Thai V. Truong, Sara Madaan, Daniel B. Holland, Scott E. Fraser
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Publication number: 20210157115Abstract: Volumetric imaging with selective volume illumination (SVI) using light field detection is provided using various systems and techniques. A volumetric imaging apparatus includes a light source configured to emit an illumination light that propagates via an illumination light path to illuminate a three-dimensional (3D) sample; and an optical system arranged with respect to the light source to receive a light field, which comes from the illuminated 3D sample. The light field propagates via a detection light path, and the light source, the optical system, or both, are configurable to perform SVI, which selects a volume of a 3D-confined illumination of the 3D sample based on the 3D sample to be illuminated and a light field detection (LFD) process to be applied. Further, the volume of the 3D-confined illumination is a selected 3D volume of the 3D sample to be particularly excited by the 3D-confined illumination for imaging.Type: ApplicationFiled: January 4, 2021Publication date: May 27, 2021Inventors: Thai V. Truong, Sara Madaan, Daniel B. Holland, Scott E. Fraser
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Patent number: 10901193Abstract: Volumetric imaging with selective volume illumination (SVI) using light field detection is provided using various systems and techniques. A volumetric imaging apparatus includes a light source configured to emit an illumination light that propagates via an illumination light path to illuminate a three-dimensional (3D) sample; and an optical system arranged with respect to the light source to receive a light field, which comes from the illuminated 3D sample. The light field propagates via a detection light path, and the light source, the optical system, or both; are configurable to perform SVI, which selects a volume of a 3D-confined illumination of the 3D sample based on the 3D sample to be illuminated and a light field detection (LFD) process to be applied. Further, the volume of the 3D-confined illumination is a selected 3D volume of the 3D sample to be particularly excited by the 3D-confined illumination for imaging.Type: GrantFiled: February 24, 2017Date of Patent: January 26, 2021Assignee: University of Southern CaliforniaInventors: Thai V. Truong, Sara Madaan, Daniel B. Holland, Scott E. Fraser
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Publication number: 20190064493Abstract: Systems and techniques relating to optimizing volumetric imaging with selective volume illumination (SVI) using light field detection, in one aspect, include: a light source configured to emit an illumination light that propagates via an illumination light path to illuminate a three-dimensional (3D) sample; and an optical system arranged with respect to the light source to receive a light field, which comes from the illuminated 3D sample, wherein the light field propagates via a detection light path; wherein the light source, the optical system, or both, are configurable to select a volume of a 3D-confined illumination of the 3D sample based on the 3D sample to be illuminated and a light field detection (LFD) process to be applied.Type: ApplicationFiled: February 24, 2017Publication date: February 28, 2019Inventors: Thai V. Truong, Sara Madaan, Daniel B. Holland, Scott E. Fraser
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Method and device to achieve spatially confined photointeraction at the focal volume of a microscope
Patent number: 9971136Abstract: The invention relates to a method and a system to achieve spatially (e.g. three-dimensionally) confined photomodulation at the focal volume (50) in a ample (55) mounted in a microscope system, comprising two or more laser light sources (41, 42) emitting light (32, 34) of different wavelengths adapted to excite a material in an identical number of independent excitation steps to a higher vibrational state from which the material relaxes, either emitting a conversion light to be detected (“photoexcitation”) or modulating the spectral properties of the material (“photomodulation”).Type: GrantFiled: March 20, 2014Date of Patent: May 15, 2018Assignees: ETH ZÜRICH, CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Periklis Pantazis, William P. Dempsey, Thai V. Truong, Scott E. Fraser, Lada Georgieva -
METHOD AND DEVICE TO ACHIEVE SPATIALLY CONFINED PHOTOINTERACTION AT THE FOCAL VOLUME OF A MICROSCOPE
Publication number: 20160054553Abstract: The invention relates to a method and a system to achieve spatially (e.g. three-dimensionally) confined photomodulation at the focal volume (50) in a ample (55) mounted in a microscope system, comprising two or more laser light sources (41, 42) emitting light (32, 34) of different wavelengths adapted to excite a material in an identical number of independent excitation steps to a higher vibrational state from which the material relaxes, either emitting a conversion light to be detected (“photoexcitation”) or modulating the spectral properties of the material (“photomodulation”).Type: ApplicationFiled: March 20, 2014Publication date: February 25, 2016Inventors: Periklis PANTAZIS, william P. DEMPSEY, Thai V. TRUONG, Scott E. FRASER, Lada GEORGIEVA -
Patent number: 8575570Abstract: An apparatus for and method of performing orthogonal light sheet microscopy (OLM) and computer optical tomography (COT) simultaneously in a single device are provided. The dual-mode imaging microscope allows for the use of both OLM and COT in a single instrument. This dual-mode device will allow researchers to have access to both types of microscopy, allowing access to the widest possible selection of samples, and improved imaging results. In addition, the device will reduce the high costs and space requirements associated with owning two different imagers (OLM and COT).Type: GrantFiled: August 25, 2011Date of Patent: November 5, 2013Assignee: California Institute of TechnologyInventors: John M. Choi, Thai V. Truong, David S. Koos
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Patent number: 8570649Abstract: An apparatus for and method of performing light sheet microscopy (LISH) and light scanning microscopy (RAPS) in a single device are provided. The dual-mode imaging microscope allows for the use of both LISH and RAPS in a single instrument. This dual-mode device will allow researchers to have access to both types of microscopy, allowing access to the widest possible selection of samples. In addition, the device will reduce the high costs and space requirements associated with owning two different microscopes (LISH and RAPS).Type: GrantFiled: October 29, 2010Date of Patent: October 29, 2013Assignee: California Institute of TechnologyInventors: Thai V. Truong, John M. Choi, Scott E. Fraser, Willy Supatto, David S. Koos
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Patent number: 8441633Abstract: An apparatus for and method of performing multi-photon light sheet microscopy (MP-LISH), combining multi-photon excited fluorescence with the orthogonal illumination of light sheet microscopy are provided. With live imaging of whole Drosophila and zebrafish embryos, the high performance of MP-LISH compared to current state-of-the-art imaging techniques in maintaining good signal and high spatial resolution deep inside biological tissues (two times deeper than one-photon light sheet microscopy), in acquisition speed (more than one order of magnitude faster than conventional two-photon laser scanning microscopy), and in low phototoxicity are demonstrated. The inherent multi-modality of this new imaging technique is also demonstrated second harmonic generation light sheet microscopy to detect collagen in mouse tail tissue. Together, these properties create the potential for a wide range of applications for MP-LISH in 4D imaging of live biological systems.Type: GrantFiled: October 29, 2010Date of Patent: May 14, 2013Assignee: California Institute of TechnologyInventors: Thai V. Truong, John M. Choi, Scott E. Fraser, Willy Supatto, David S. Koos
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Publication number: 20120049087Abstract: An apparatus for and method of performing orthogonal light sheet microscopy (OLM) and computer optical tomography (COT) simultaneously in a single device are provided. The dual-mode imaging microscope allows for the use of both OLM and COT in a single instrument. This dual-mode device will allow researchers to have access to both types of microscopy, allowing access to the widest possible selection of samples, and improved imaging results. In addition, the device will reduce the high costs and space requirements associated with owning two different imagers (OLM and COT).Type: ApplicationFiled: August 25, 2011Publication date: March 1, 2012Applicant: California Institute of TechnologyInventors: John M. Choi, Thai V. Truong, David S. Koos
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Publication number: 20110134521Abstract: An apparatus for and method of performing light sheet microscopy (LISH) and light scanning microscopy (RAPS) in a single device are provided. The dual-mode imaging microscope allows for the use of both LISH and RAPS in a single instrument. This dual-mode device will allow researchers to have access to both types of microscopy, allowing access to the widest possible selection of samples. In addition, the device will reduce the high costs and space requirements associated with owning two different microscopes (LISH and RAPS).Type: ApplicationFiled: October 29, 2010Publication date: June 9, 2011Applicant: California Institute of TechnologyInventors: Thai V. Truong, John M. Choi, Scott E. Fraser, Willy Supatto, David S. Koos
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Publication number: 20110122488Abstract: An apparatus for and method of performing multi-photon light sheet microscopy (MP-LISH), combining multi-photon excited fluorescence with the orthogonal. illumination of light sheet microscopy are provided. With live imaging of whole Drosophila and zebrafish embryos, the high performance of MP-LISH compared to current state-of-the-art imaging techniques in maintaining good signal and high spatial resolution deep inside biological tissues (two times deeper than one-photon light sheet microscopy), in acquisition speed (more than one order of magnitude faster than conventional two-photon laser scanning microscopy), and in low phototoxicity are demonstrated. The inherent multi-modality of this new imaging technique is also demonstrated second harmonic generation light sheet microscopy to detect collagen in mouse tail tissue. Together, these properties create the potential for a wide range of applications for MP-LISH in 4D imaging of live biological systems.Type: ApplicationFiled: October 29, 2010Publication date: May 26, 2011Applicant: California Institute of TechnologyInventors: Thai V. Truong, John M. Choi, Scott E. Fraser, Willy Supatto, David S. Koos