Patents by Inventor Thaiz BORIN

Thaiz BORIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENGINEERED EXOSOMES TO DETECT AND DEPLETE PRO-TUMORIGENIC MACROPHAGES
    Publication number: 20240075161
    Abstract: An engineered targeting exosome comprising; a modified Lamp2b peptide, a targeting peptide or antibody; and a Fc portion of IgG2b. The targeting peptide or antibody detects a target protein within a cell and precisely delivers the exosome to cells expressing the target protein and the Fc portion of IgGb2 induces antibody-dependent cell-mediated cytotoxicity (ADCC) events in cells expressing the target protein. Also disclosed are methods of using the engineered targeting exosome to detect and/or deplete cells expressing the target protein.
    Type: Application
    Filed: November 2, 2023
    Publication date: March 7, 2024
    Applicant: AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.
    Inventors: Ali ARBAB, Mohammad Harun RASHID, Thaiz BORIN, Roxan ARA
  • Engineered Exosomes to Detect and Deplete Pro-Tumorigenic Macrophages
    Publication number: 20210130782
    Abstract: CD206-positive M2 macrophage-targeting exosomes and methods of use thereof are provided. One embodiment provides a CD206-positive M2 macrophage-targeting exosome expressing a CD206 binding peptide and an Fc portion of IgG2b. In some embodiments, the CD206 binding peptide is encoded by a nucleic acid sequence having 95%, 99%, or 100% sequence identity to SEQ ID NO:2 and the IgG2b is encoded by a sequence having 95%, 99%, or 100% sequence identity to SEQ ID NO:6.
    Type: Application
    Filed: October 28, 2020
    Publication date: May 6, 2021
    Applicant: Augusta University Research Institute, Inc.
    Inventors: Ali ARBAB, Mohammad Harun RASHID, Thaiz BORIN, Roxan ARA