Abstract: The present application provides methods of treating a cancer in a subject who has one or more mutations in the LKB1 pathway.

Abstract: Apparatuses, systems and methods for implementing a downhole alternator assembly are disclosed. In some embodiments, a downhole alternator assembly comprises a casing; a turbine disposed within the casing and actuated by a drilling fluid flow; and a rotor disposed within the casing. The rotor includes a cylindrical rotor core rotated by the turbine; a plurality of permanent magnets disposed in the cylindrical rotor core; and a drilling fluid channel extending axially through the center of the cylindrical rotor core. The downhole alternator assembly includes a stator disposed within the casing. The stator includes a cylindrical stator core disposed concentrically between the cylindrical rotor core and the casing; conductor windings within the cylindrical stator core; and a plurality of radially distributed fluid channels extending axially within the cylindrical stator core between a front end of the cylindrical stator core and a back end of the cylindrical stator core.

Abstract: Method is provided for determining the extent of defects, in particular of crack depths, in a test specimen. At least one transmitting transducer excites sound waves in the ultrasonic range, and the sound waves propagate in the form of a sound beam. The acoustic axis of the sound beam preferably forms an angle the normal to a surface of the test specimen facing the transmitting transducer. The sound waves couple into the test specimen obliquely and are reflected in particular in a V-shaped manner at a preferably outer interface of the test specimen. At least one receiving transducer spaced apart from the transmitting transducer receives the sound waves reflected at the interface of the test specimen. By means of an evaluation unit, an extent of a defect arranged within a sound path is determined from a reduction of the amplitude of the sound waves received by the receiving transducer.

Abstract: Disclosed is an apparatus comprising means for transmitting a first signal via at least a first switch, a first amplifier, a second switch and a power amplifier, wherein an output of the second switch is connected to a power amplifier path comprising at least the power amplifier, while transmitting the first signal. An input of the first switch and the output of the second switch are switched to switch between transmitting and receiving. A second signal is received via at least the first switch, the first amplifier and the second switch, wherein the output of the second switch is disconnected from the power amplifier path while receiving the second signal.

Abstract: A sintering furnace can include an outer shell defining an internal volume a reactive agent inlet configured to introduce a reactive agent into the internal volume; an insulation chamber within the outer shell; and a retort configured to retain an object. A method of operating a sintering furnace can include sintering a part precursor within a retort arranged within a chamber, wherein the chamber defines an intermediate volume between the retort and the chamber, wherein a sintering byproduct is oxidized within the intermediate volume.

Abstract: The invention addresses to a system and method that allow controlling the individual power flow of each battery, being indicated for energy accumulator systems of the electrochemical-battery type, solidly connected to the electrical grid, respecting each of its characteristics during operation. Thus, if the batteries present different states of charge, the system will be responsible for draining from each battery only the amount of energy that can be used. For different states of health, charge and life, the performance and discharge capacity are preserved. For degraded batteries, the system allows their replacement without the need of replacing the entire bank, including batteries with different technologies.

Abstract: The present invention provides novel heterocylic amide compounds having useful antimycobacterial activity. Use of these compounds as pharmaceutical compositions and method of their production are also provided.

Abstract: A method is disclosed for determining a mechanical-technological characteristic variable of ferromagnetic metals, preferably ferromagnetic steels, and in particular fine-grained steels, which are used in pipelines. A magnetization apparatus, which has at least one permanent magnet or solenoid, magnetizes the metal which is to be determined, and a sensor apparatus comprising a transmission coil generates a magnetic field which interacts with the magnetic field which is generated by the magnetization apparatus in the metal, and which generates an eddy current. The eddy current is generated in the magnetically at least substantially saturated metal, and the eddy current is measured by an eddy current sensor of the sensor apparatus.

Abstract: A sintering furnace can include an outer shell defining an internal volume a reactive agent inlet configured to introduce a reactive agent into the internal volume; an insulation chamber within the outer shell; and a retort configured to retain an object. A method of operating a sintering furnace can include sintering a part precursor within a retort arranged within a chamber, wherein the chamber defines an intermediate volume between the retort and the chamber, wherein a sintering byproduct is oxidized within the intermediate volume.

Abstract: A method is provided for determining at least one material characteristic of a magnetizable metal body by means of a micromagnetic sensor arrangement, which comprises at least one excitation coil having a magnetic core for signal excitation and at least one receiver. The body is magnetized by the sensor arrangement via current or voltage excitation of the sensor arrangement, which comprises at least one sign change between a positive part of a half-wave and a negative part of a half-wave. At least one signal is measured in the receiver, and the signal is Fourier transformed. The material characteristic are determined from at least one Fourier component. The excitation is turned off, and the post-oscillation of the signal is measured in the receiver. At least the part of the signal resulting from the post-oscillation in the Fourier transformation is used.

Abstract: Apparatuses, systems and methods for implementing a downhole alternator assembly are disclosed. In some embodiments, a downhole alternator assembly comprises a casing; a turbine disposed within the casing and actuated by a drilling fluid flow; and a rotor disposed within the casing. The rotor includes a cylindrical rotor core rotated by the turbine; a plurality of permanent magnets disposed in the cylindrical rotor core; and a drilling fluid channel extending axially through the center of the cylindrical rotor core. The downhole alternator assembly includes a stator disposed within the casing. The stator includes a cylindrical stator core disposed concentrically between the cylindrical rotor core and the casing; conductor windings within the cylindrical stator core; and a plurality of radially distributed fluid channels extending axially within the cylindrical stator core between a front end of the cylindrical stator core and a back end of the cylindrical stator core.

Abstract: A sintering furnace can include an outer shell defining an internal volume a reactive agent inlet configured to introduce a reactive agent into the internal volume; an insulation chamber within the outer shell; and a retort configured to retain an object. A method of operating a sintering furnace can include sintering a part precursor within a retort arranged within a chamber, wherein the chamber defines an intermediate volume between the retort and the chamber, wherein a sintering byproduct is oxidized within the intermediate volume.

Abstract: A sintering furnace can include an outer shell defining an internal volume a reactive agent inlet configured to introduce a reactive agent into the internal volume; an insulation chamber within the outer shell; and a retort configured to retain an object. A method of operating a sintering furnace can include sintering a part precursor within a retort arranged within a chamber, wherein the chamber defines an intermediate volume between the retort and the chamber, wherein a sintering byproduct is oxidized within the intermediate volume.

Abstract: Multipurpose biological compositions, for the biological control of phytopathogens, phytonematodes, agricultural pests, inoculating agent, phosphorus solubilization, soil conditioning, biostimulant, reduction of hydric stress in cultivated plants and bioremediation in cultivatable areas, contains mixtures of additives and excipients with at least two species from Bacilales order; or at least two strains from the same species, or mutants thereof; (b) at least two fungi from Hypocreales, Orbiliales, Helotiales and Mucorales order, and mutants thereof; or at least two strains from the same species from Hypocreales, Orbiliales, Helotiales and Mucorales orders; and combinations among the whole or part thereof; in c.f.u., in association with or separated from of agrochemicals, essential oil of plants, and plant extract.

Abstract: The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of lung cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose lung cancer or permit the differential diagnosis of pulmonary nodules as benign or malignant. In another aspect, methods are provided for diagnosing lung cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 18, Table 20, or Table 21, wherein the individual is classified as having lung cancer, or the likelihood of the individual having lung cancer is determined, based on the at least one biomarker value.

Abstract: A technology is directed to embedded device updates. In one example of the technology, a partition of a memory is atomically updated. The partition includes partition tables including a primary partition table and a back-up partition table. The partition tables include entries for the images included in the partition, and information associated with the images included in the partition. Atomically updating the partition of the memory includes writing an updated version to the partition. The written updated version is verified. An updated partition table is written to the back-up partition table. The updated partition table is written to the primary partition table. If it is determined that a power, or other, fault occurred while the primary partition table was being written, the primary partition table is overwritten with the back-up partition table.

Abstract: Aptamers that bind PDGF and aptamers that bind VEGF are provided. In addition, aptamer constructs comprising a PDGF aptamer and a VEGF aptamer are provided. Pharmaceutical compositions comprising the aptamers and aptamer constructs are provided, as well as methods of treating conditions using the aptamers and aptamer constructs.

Abstract: Multi-functional biological compositions are provided for reducing hydric stress and promoting growth in cultivated plants, for use as an inoculant, as a soil conditioner, as a biostimulant, for phosphorus solubilization and for bioremediation in agricultural areas. In particular, compositions containing mixtures of additives and excipients are provided having at least 2 (two) or more species of Bacillus or two or more strains of a single species, or the mutants thereof, concomitantly with additives and excipients, in biological compositions with properties for reducing hydric stress and promoting growth in cultivated plants, for use as an inoculant, as a biological soil conditioner, as a biostimulant, for phosphorus stabilization and for bioremediation in agricultural areas, added to the coating/encrustation used in industrial or non-industrial seed treatment, applied in furrows, using a guided boom or by other application means.

Abstract: Multiple-function biological compositions for the biological control of phytopathogens, phytonematodes and agricultural pests are provided for use as an inoculant, for phosphorus solubilization, for soil conditioning, for use as a biostimulant, for hydric stress reduction in cultivated plants and for bioremediation in agricultural or non-agricultural areas. The compositions contain mixtures of additives and excipients having at least two genera and/or species of Actinomycetes or other bacterial species, so as to provide nematicidal effects, fungicidal effects. insecticidal action in the reduction of damage and control of insects, and other properties such as growth-promotion and soil conditioning. The compositions may also be used, for use as a biostimulant, for hydric stress mitigation in cultivated plants, and for bioremediation in agricultural or non-agricultural areas.

Abstract: The present disclosure relates to a method of treating a subject having cancer that includes selecting a subject having cancer associated with a deregulated NRF2/KEAP1 pathway and administering to the selected subject one or more inhibitors comprising a glutamine transporter inhibitor; a GPD2 inhibitor; or combination(s) thereof.