Abstract: Systems and methods are disclosed that can provide estimates of elasto-plastic properties of material samples using data from instrumented indentation tests. Alternatively, or in addition, estimated load-depth curves can be constructed by certain methods and systems provided based on known mechanical properties. Some disclosed systems and methods use large deformation theory for at least part of the analysis and/or determinations and/or may account for strains of at least 5% in the area of contact between the indenter and the material sample, which can result in more accurate estimates of mechanical properties and/or deformation behavior.