Patents by Inventor Thane L. Kranzler
Thane L. Kranzler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10173038Abstract: The invention is directed to delivery medical devices that enable consistent “on-demand” delivery of therapeutic agents to a vessel. The medical device of the current invention comprises retractable sheath comprising neckable elements. The medical device of the current invention comprises an expandable member, a hydrophilic coating comprising at least one therapeutic agent about the expandable member or structural layer and a retractable outer sheath with a selectively permeable microstructure. The design and methods disclosed herein ensures that therapeutic agent delivery occurs essentially only during retraction of the outer sheath, minimizing coating and/or therapeutic agent loss to the bloodstream and providing controlled delivery to the treatment site.Type: GrantFiled: September 4, 2013Date of Patent: January 8, 2019Assignee: W. L. Gore & Associates, Inc.Inventors: Carey V. Campbell, Robert L. Cleek, Edward H. Cully, Peter Heicksen, Theresa A. Holland, Thane L. Kranzler, Mei Li, Bruce M. Steinhaus, Benjamin M. Trapp, Thomas G. Triebes, Michael J. Vonesh
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Patent number: 9415193Abstract: The invention is directed to eluting medical devices that enable consistent “on-demand” delivery of therapeutic agents to a vessel. The medical device of the current invention comprises an expandable member, a hydrophilic coating comprising at least one therapeutic agent about the expandable member or structural layer and an outer sheath with a variably permeable microstructure. The design and methods disclosed herein ensures that therapeutic agent delivery occurs essentially only during expansion of the expandable member, minimizing coating and/or therapeutic agent loss to the bloodstream and providing controlled delivery to the treatment site.Type: GrantFiled: September 4, 2012Date of Patent: August 16, 2016Assignee: W. L. Gore & Associates, Inc.Inventors: Carey V. Campbell, Robert L. Cleek, Daniel L. Crandall, James F. Davidson, Paul D. Drumheller, Cody L. Hartman, Theresa A. Holland, Thane L. Kranzler, Mei Li, Gregory LoStracco, Bruce M. Steinhaus, Benjamin M. Trapp, Thomas G. Triebes
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Publication number: 20140066897Abstract: The invention is directed to delivery medical devices that enable consistent “on-demand” delivery of therapeutic agents to a vessel. The medical device of the current invention comprises retractable sheath comprising neckable elements. The medical device of the current invention comprises an expandable member, a hydrophilic coating comprising at least one therapeutic agent about the expandable member or structural layer and a retractable outer sheath with a selectively permeable microstructure. The design and methods disclosed herein ensures that therapeutic agent delivery occurs essentially only during retraction of the outer sheath, minimizing coating and/or therapeutic agent loss to the bloodstream and providing controlled delivery to the treatment site.Type: ApplicationFiled: September 4, 2013Publication date: March 6, 2014Applicant: W. L. Gore & Associates, Inc.Inventors: Carey V. Campbell, Robert L. Cleek, Edward H. Cully, Peter Heicksen, Theresa A. Holland, Thane L. Kranzler, Mei Li, Bruce M. Steinhaus, Benjamin M. Trapp, Thomas G. Triebes, Michael J. Vonesh
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Publication number: 20120310210Abstract: The invention is directed to eluting medical devices that enable consistent “on-demand” delivery of therapeutic agents to a vessel. The medical device of the current invention comprises an expandable member, a hydrophilic coating comprising at least one therapeutic agent about the expandable member or structural layer and an outer sheath with a variably permeable microstructure. The design and methods disclosed herein ensures that therapeutic agent delivery occurs essentially only during expansion of the expandable member, minimizing coating and/or therapeutic agent loss to the bloodstream and providing controlled delivery to the treatment site.Type: ApplicationFiled: March 1, 2012Publication date: December 6, 2012Inventors: Carey V. Campbell, Robert L. Cleek, Theresa A. Holland, Thane L. Kranzler, Benjamin M. Trapp
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Publication number: 20100106258Abstract: An improved, polymeric surgical membrane, which can be used in a variety of surgical procedures, such as sutured and sutureless duraplasty procedures. For sutureless applications, a textured, discontinuous, outer polymer layer is provided which encourages rapid incorporation and anchoring into surrounding tissue. In cooperation with the discontinuous first layer, a second elastomeric layer provides elasticity and resilience. A third barrier layer is provided to essentially eliminate adhesions and irritation to surrounding tissue. In those applications requiring anchoring sutures, the second elastomeric layer “self-seals” against the sutures, essentially eliminating the leakage of blood, cerebrospinal fluid, or other fluids. In addition, the composite structure of the present invention has a high degree of suture retention strength is polymeric with a high degree of biocompatibility, is thin and very flexible.Type: ApplicationFiled: November 24, 2009Publication date: April 29, 2010Inventors: Andrew B. Berman, Thane L. Kranzler, Dean R. Wentworth
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Publication number: 20030204270Abstract: An improved, polymeric surgical membrane, which can be used in a variety of surgical procedures, such as sutured and sutureless duraplasty procedures. For sutureless applications, a textured, discontinuous, outer polymer layer is provided which encourages rapid incorporation and anchoring into surrounding tissue. In cooperation with the discontinuous first layer, a second elastomeric layer provides elasticity and resilience. A third barrier layer is provided to essentially eliminate adhesions and irritation to surrounding tissue. In those applications requiring anchoring sutures, the second elastomeric layer “self-seals” against the sutures, essentially eliminating the leakage of blood, cerebrospinal fluid, or other fluids. In addition, the composite structure of the present invention has a high degree of suture retention strength is polymeric with a high degree of biocompatibility, is thin and very flexible.Type: ApplicationFiled: April 25, 2002Publication date: October 30, 2003Inventors: Andrew B. Berman, Thane L. Kranzler, Dean R. Wentworth
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Patent number: 5645915Abstract: A high strength, porous PTFE sheet material having high strength in all directions within the plane of the sheet material. The sheet material has, within the plane of the sheet, a higher minimum tensile strength, matrix tensile strength, secant modulus and matrix secant modulus than previously known porous PTFE sheet materials. The sheet material is a laminate of multiple layers of porous PTFE film, preferably uniaxially expanded film, wherein the orientation of the direction of the fibrils of any layer varies slightly, such as about ten degrees, from the orientation of the fibrils of the adjacent layer. The sheet material is particularly useful as a surgical repair patch and especially as a blood vessel repair patch because of its high strength, flexibility, biocompatibility and very low rate of suture line bleeding.Type: GrantFiled: March 29, 1996Date of Patent: July 8, 1997Assignee: W. L. Gore & Associates, Inc.Inventors: Thane L. Kranzler, Jon P. Moseley
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Patent number: 5641566Abstract: A high strength, porous PTFE sheet material having high strength in all directions within the plane of the sheet material. The sheet material has, within the plane of the sheet, a higher minimum tensile strength, matrix tensile strength, secant modulus and matrix secant modulus than previously known porous PTFE sheet materials. The sheet material is a laminate of multiple layers of porous PTFE film, preferably uniaxially expanded film, wherein the orientation of the direction of the fibrils of any layer varies slightly, such as about ten degrees, from the orientation of the fibrils of the adjacent layer. The sheet material is particularly useful as a surgical repair patch and especially as a blood vessel repair patch because of its high strength, flexibility, biocompatibility and very low rate of suture line bleeding.Type: GrantFiled: December 6, 1995Date of Patent: June 24, 1997Assignee: W. L. Gore & Associates, Inc.Inventors: Thane L. Kranzler, Jon P. Moseley
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Patent number: 5614284Abstract: A sheet of implantable patch tissue repair material having the form of a layer of porous polytetrafluoroethylene sheet material laminated to a layer of mesh-type sheet material having a multiplicity of openings through the mesh-type sheet material, said openings having a mean minimum diameter of about 0.1 mm. The inventive patch tissue repair material offers good strength characteristics, good biocompatibility, suture retention, and flexibility.Type: GrantFiled: April 13, 1995Date of Patent: March 25, 1997Assignee: W. L. Gore & Associates, Inc.Inventors: Thane L. Kranzler, Michael L. McDonald
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Patent number: 5433996Abstract: A sheet of implantable patch tissue repair material comprising a layer of porous polytetrafluoroethylene sheet material laminated to a layer of mesh-type sheet material having a multiplicity of openings through the mesh-type sheet material, said openings having a mean minimum diameter of at least about 0.1 mm. The inventive patch tissue repair material offers good strength characteristics, good biocompatibility, suture retention, and flexibility.Type: GrantFiled: February 18, 1993Date of Patent: July 18, 1995Assignee: W. L. Gore & Associates, Inc.Inventors: Thane L. Kranzler, Michael L. McDonald
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Patent number: 5098779Abstract: A carvable implant material for use in surgery and especially in plastic and reconstructive surgery is described which comprises porous PTFE having a coating of a stiffening agent intended to stiffen the PTFE in order to render it carvable. This material may thus be carved into a desired shape prior to implantation. The stiffening agent is biodegradable to allow tissue ingrowth to stabilize the location of the implant as the biodegradable stiffening agent is degraded and absorbed by the body.Type: GrantFiled: June 25, 1990Date of Patent: March 24, 1992Assignee: W. L. Gore & Associates, Inc.Inventors: Thane L. Kranzler, Norman J. Sharber