Abstract: Novel intermediate compounds are disclosed. These compounds are useful in the synthesis of 4-aminopyrimidine-5-one derivatives that inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). The 4-aminopyrimidine-5-one derivatives and their pharmaceutically acceptable salts have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors.

Abstract: There are presented compounds of the formula or pharmaceutically acceptable salts thereof, wherein Y1, Y2, X1, X2, X3 and R are as described in this application. These compounds are believed to inhibit MDM2-p53 interaction and as such the compounds will have anti-hyperproliferative cellular activity.

Abstract: and the pharmaceutically acceptable salts and esters thereof, wherein X1, X2, X3, Y1, Y2 and R are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proliferative activity.

Abstract: There are provided compounds of the formula or the pharmaceutically acceptable salts thereof, wherein X, Y, Z, V1, V2, R1, R2, R3, R4 and R5 are herein described. These compounds are useful as anticancer agents.

Abstract: and the pharmaceutically acceptable salts and esters thereof X, R1, R2, Y1 and Y2 are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proliferative activity.

Abstract: The present invention provides compounds according to formula I having the designations provided herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity.

Abstract: A multiple task wait system and associated method allow a client application to wait for multiple tasks to be successfully or conditionally implemented before running subsequent tasks. Two mechanisms can be used to accomplish this multiple wait process: The first mechanism uses a multi-wait grouping process that is visible to the client, and the second mechanism uses a graphical representation to identify the tasks to be completed. The multi-wait grouping process allows a client to group a related set of tasks together for both control and documentation purposes. The client can add as many tasks as the resources of the computer allow to a group while defining the data flows and control flows between the tasks in the group using various graphical tools. The multi-wait system allows the client to define the constraints and conditions for a set of tasks to be considered complete, and further allows the system to define the constraints and conditions for considering all the tasks within the group to be completed.

Abstract: Novel 4-aminopyrimidine-5-one derivatives are disclosed. These compounds inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 4-aminopyrimidine-5-one derivatives.

Abstract: The present invention provides compounds according to formula I and pharmaceutically acceptable salts and esters thereof, having the designations provided herein and which inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity

Abstract: The present invention provides compounds according to formula I 1

Abstract: The present invention provides compounds according to formula I and pharmaceutically acceptable salts and esters thereof, having the designations provided herein and which inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity.

Abstract: The present invention provides compounds according to formula I and formula II and pharmaceutically acceptable salts and esters thereof, having the designations provided herein and which inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity.

Abstract: Novel 4-aminopyrimidine-5-one derivatives are disclosed. These compounds inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 4-aminopyrimidine-5-one derivatives.

Abstract: The present invention provides compounds according to formula I and formula II and pharmaceutically acceptable salts and esters thereof, having the designations provided herein and which inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity.

Abstract: A multiple task wait system and associated method allow a client application to wait for multiple tasks to be successfully or conditionally implemented before running subsequent tasks. Two mechanisms can be used to accomplish this multiple wait process: The first mechanism uses a multi-wait grouping process that is visible to the client, and the second mechanism uses a graphical representation to identify the tasks to be completed. The multi-wait grouping process allows a client to group a related set of tasks together for both control and documentation purposes. The client can add as many tasks as the resources of the computer allow to a group while defining the data flows and control flows between the tasks in the group using various graphical tools. The multi-wait system allows the client to define the constraints and conditions for a set of tasks to be considered complete, and further allows the system to define the constraints and conditions for considering all the tasks within the group to be completed.

Abstract: The present invention provides compounds according to formula I and formula II and pharmaceutically acceptable salts and esters thereof, having the designations provided herein and which inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity

Abstract: The present invention provides compounds according to formula I and formula II and pharmaceutically acceptable salts and esters thereof, having the designations provided herein and which inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity.

Abstract: A facility is provided for interfacing the Internet with a telecommunications network and vice versa so that a user who does not have access to the Internet may, nevertheless, provide a Web page and update the Web page via the telecommunications network and so that a user may access the telecommunications network via the Internet.

Abstract: A facility is provided for interfacing the Internet with a telecommunications network and vice versa so that a user who does not have access to the Internet may, nevertheless, provide a Web page and update the Web page via the telecommunications network and so that a user may access the telecommunications network via the Internet.

Abstract: A low temperature co-fired ceramic ("LTCC") structure containing capacitors buried therein. To avoid distortion, cracking or bowing during the co-firing process, high K dielectric material is placed between each electrode of each capacitor and low K dielectric is arranged symmetrically with respect to a plane passing through the approximate center of the high K dielectric material. Single as well as multiple stacked capacitors can be successfully buried, all without appreciable distortion, cracking or bowing.