Abstract: A variable focal length achromatic lens includes a flat liquid crystal diffractive lens and a pressure-controlled fluidic refractive lens. The diffractive lens is composed of a flat binary Fresnel zone structure and a thin liquid crystal layer, producing high efficiency and millisecond switching times while applying a low ac voltage input. The focusing power of the diffractive lens is adjusted by electrically modifying the sub-zones and re-establishing phase wrapping points. The refractive lens includes a fluid chamber with a flat glass surface and an opposing elastic polydimethylsiloxane (PDMS) membrane surface. Inserting fluid volume through a pump system into the clear aperture region alters the membrane curvature and adjusts the refractive lens' focal position. Primary chromatic aberration is remarkably reduced through the coupling of the fluidic and diffractive lenses at a number of selected focal lengths.

Abstract: A system is provided for evaluating MIS procedures. The system includes a sensor configured to receive task-performance data, block components, and actuating components. The sensor, block components, and actuating components are configured to simulate a training task. The system also includes a processor. The processor is configured to determine, based on the received task-performance data, a trial task-performance metric corresponding to a trial performance of the training task. The processor is also configured to select a reference task-performance metric from a plurality of reference task-performance metrics. Each reference task-performance metric in the plurality corresponds to a respective reference performance of the training task. The processor is additionally configured to determine, based on a comparison of the trial task-performance metric to the reference task-performance metric, a task-performance classification level.

Abstract: Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.

Abstract: A phoropter having a line of sight for a viewer to see through comprises a lens system in the line of sight, wherein a shape or focal length of at least one lens in the lens system is controllable by means of an electrical signal, electrical field or current. Wavefront sensors of the phoropter detect local tilts of light wavefronts emerging from the eye and generate output signals that are used for controlling the shape or focal length of the at least one lens. Holographic or diffractive elements are used to collect light scattered from an eye of the viewer and image the scattered light to the wavefront sensors. Preferably one or more of the holographic or diffractive elements are away from the line of sight of the viewer. To use the phoropter, light is passed to the lens system, and light scattered by the eye is collected by the holographic or diffractive elements and imaged onto the wavefront sensors.

Abstract: An apparatus and method of image reconstruction are disclosed. The method includes first breaking a holographic image into a plurality of interlaced sample sets corresponding to color separation images; and independently sampling, filtering, and reconstructing all sets. The resulting demodulated images contain no fringes. Notably, range-clipped tonal rendering curves are used to choose pixel regions of the demodulated images that will replace saturated regions. The image is reconstructed by integrating all un-saturated images into one.